2015
DOI: 10.1142/s0219519415500049
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Fabrication of 3d Mili-Scale Channels for Hemodynamic Studies

Abstract: 3D mili-scale channel representing simplified anatomical models of blood vessels were constructed in polidimethylsiloxane (PDMS). The objective was to obtain a sequential method to fabricate transparent PDMS models from a mold produced by rapid prototyping. For this purpose, two types of casting methods were compared, a known lost-wax casting method and a casting method using sucrose. The channels fabricated by both casting methods were analyzed by Optical Microscopy, Scanning Electron Microscopy (SEM), and En… Show more

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Cited by 18 publications
(16 citation statements)
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References 34 publications
(40 reference statements)
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“…The fluid selected as blood analogue was a dimethyl sulfoxide (DMSO)/water mixture (52%/42%‐w/w), μ = 0.0035 Pa second and ρ = 1057.5 kg m −3 . This mixture eliminates the visual distortion given by the curvature of the phantoms walls by matching the refractive index of the PDMS . Although in small arteries and capillaries the blood exhibits non‐Newtonian behavior, in vessels of larger diameter, such as the coronary artery tree, the non‐Newtonian behavior is small because of the predominant high‐shear rates.…”
Section: Methodssupporting
confidence: 70%
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“…The fluid selected as blood analogue was a dimethyl sulfoxide (DMSO)/water mixture (52%/42%‐w/w), μ = 0.0035 Pa second and ρ = 1057.5 kg m −3 . This mixture eliminates the visual distortion given by the curvature of the phantoms walls by matching the refractive index of the PDMS . Although in small arteries and capillaries the blood exhibits non‐Newtonian behavior, in vessels of larger diameter, such as the coronary artery tree, the non‐Newtonian behavior is small because of the predominant high‐shear rates.…”
Section: Methodssupporting
confidence: 70%
“…The 3D geometry designs were saved in STL format file for both numerical meshing and for constructing the experimental phantoms by rapid prototyping. The flow phantoms were prepared using a previously process developed by the authors . This method combines rapid prototyping (stereolithography) with sucrose molding and allows obtaining 3D poly (dimethylsiloxane) (PDMS) flow phantoms with any desired geometry.…”
Section: Methodsmentioning
confidence: 99%
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“…Nevertheless, they face serious limitations for the case of hemodynamic studies. As visualizing the inner flow is imperative, they must be transparent to white light, its thickness should be less than the focal length of the objective used for experimental testing [17] and the used material must have a refractive index as closest as possible to the fluid one [18] .…”
Section: Introductionmentioning
confidence: 99%