Fabrication of 3D micropatterns with high hosting cell efficiency and their effects on osteogenic differentiation of MSCs

Wu, Feige; Yang, Gaojie; Li, Yan; Wang, Yifan; Tan, Shenglong; Du, Yingying; Zhong, Zhenyu; Lan, Ziyang; Zhang, Shengmin

doi:10.1016/j.matlet.2021.130045

Cited by 4 publications

(2 citation statements)

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“…156 Wu et al suggested that rectangular and triangular micropatterns can effectively guide the directional osteogenic differentiation of BMSC through the Yesassociated protein/Tafazzin (YAP/TAZ) signaling pathway. 157 In Lu's study, it was demonstrated that the specific pore structure of scaffold materials enhances cell adhesion, proliferation, migration, and osteogenic differentiation of BMSC by improving the mechanical signal transduction of the RhoA/ROCK pathway and promoting the secretion of growth factors related to cell migration. 158 As previously mentioned, metal ions such as Mg 2+ , Ca 2+ , and Sr 2+ not only contribute to high strength, excellent stability, and intelligent temperature and pH responsiveness in hydrogel materials but also enable the formation of pore structures conducive to bone tissue and blood vessel growth within the hydrogel.…”

Section: Recent Research Progress and Prospectsmentioning

confidence: 99%

“…For instance, Bidan et al used 3D printing to create cell culture scaffolds with varying hole shapes and found that concave holes accelerated bone tissue deposition . Wu et al suggested that rectangular and triangular micropatterns can effectively guide the directional osteogenic differentiation of BMSC through the Yes-associated protein/Tafazzin (YAP/TAZ) signaling pathway . In Lu’s study, it was demonstrated that the specific pore structure of scaffold materials enhances cell adhesion, proliferation, migration, and osteogenic differentiation of BMSC by improving the mechanical signal transduction of the RhoA/ROCK pathway and promoting the secretion of growth factors related to cell migration …”

Section: Recent Research Progress and Prospectsmentioning

confidence: 99%

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Metal Ion-Containing Hydrogels: Synthesis, Properties, and Applications in Bone Tissue Engineering

Qin,

Niu,

Zhang

et al. 2024

Biomacromolecules

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Hydrogel, as a unique scaffold material, features a three-dimensional network system that provides conducive conditions for the growth of cells and tissues in bone tissue engineering (BTE). In recent years, it has been discovered that metal ion-containing hybridized hydrogels, synthesized with metal particles as the foundation, exhibit excellent physicochemical properties, osteoinductivity, and osteogenic potential. They offer a wide range of research prospects in the field of BTE. This review provides an overview of the current state and recent advancements in research concerning metal ion-containing hydrogels in the field of BTE. Within materials science, it covers topics such as the binding mechanisms of metal ions within hydrogel networks, the types and fabrication methods of various metal ion-containing hydrogels, and the influence of metal ions on the properties of hydrogels. In the context of BTE, the review delves into the osteogenic mechanisms of various metal ions, the applications of metal ion-containing hydrogels in BTE, and relevant experimental studies in vitro and in vivo. Furthermore, future improvements in bone repair can be anticipated through advancements in bone bionics, exploring interactions between metal ions and the development of a wider range of metal ions and hydrogel types.

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Section: Recent Research Progress and Prospectsmentioning

confidence: 99%

Section: Recent Research Progress and Prospectsmentioning

confidence: 99%