Fabrication, multi-scale characterization and in-vitro evaluation of porous hybrid bioactive glass polymer-coated scaffolds for bone tissue engineering

Chlanda, Adrian; Oberbek, Przemysław; Heljak, Marcin; Kijeńska‐Gawrońska, Ewa; Bolek, Tomasz; Gloc, Michał; John, Łukasz; Janeta, Mateusz; Woźniak, Michał

doi:10.1016/j.msec.2018.09.062

Cited by 22 publications

(7 citation statements)

References 69 publications

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“…This can be overcome by the enhancement of BAGs with organic-inorganic hybrids during their formulation [31,32]. Organic-inorganic hybrids, provided in polymeric bases, attach to the silica component of BAG through covalent bonds, thereby increasing BAG flexibility and providing better control over the mechanical properties of BAGs [31][32][33].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Bioactive Glass-Enhanced Orthodontic Bonding Resins on Prevention of Demineralization: A Systematic Review

2020

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At present, bioactive glasses (BAGs) are demonstrating promising results in the remineralization of hard tissues. Their bioactive properties can potentially overcome the demineralization effect accompanying orthodontic treatment. This review aimed to evaluate the effectiveness of bioactive glass enhanced orthodontic bonding resins on enamel remineralization, in addition to their antibacterial, ion release and acid neutralization effect. Four databases (PubMed, MEDLINE, Web of Science and Scopus) were searched. Two hundred and fifty-one full-text articles were screened independently, out of which seven studies satisfied the inclusion criteria. Quality appraisal was performed by two independent reviewers. Methodologies used to assess the anti-demineralization effect included Micro-Computed Tomography, Polarized Light Microscopy and Hardness Testing (Knoop and Berkovich). All seven articles confirmed the superior remineralization effect of BAG orthodontic bonding resins compared to their non-BAG counterparts. A proportional relationship was proved between BAG concentrations and increased anti-demineralization effect. The addition of antibacterial agents to BAG does not necessarily improve its anti-demineralization effect. Although studies have confirmed the effectiveness of BAG orthodontic bonding resins on enamel remineralization, there was a degree of heterogeneity across studies due to the lack of an in vitro studies standardized protocol.

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Section: Introductionmentioning

confidence: 99%

The Effect of Bioactive Glass-Enhanced Orthodontic Bonding Resins on Prevention of Demineralization: A Systematic Review

2020

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“…The recourse to the nanotechnology can help to overcome such drawback and to meet the actual material development requirements including good electrical and thermal conductivity properties [ 12 , 13 ]. Composite scaffolds of different materials (including PLA due to its biocompatibility) for the next generation design and manufacturing of medical implants, especially in bone tissue engineering, were proposed, produced and then structurally and mechanically investigated in micro and nanoscale [ 14 , 15 , 16 ]. Additive Manufacturing technology is increasingly adopted in medical for different applications and its contemporary and future benefits are analyzed in Javaid and Haleem [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Dielectric Spectroscopy and Thermal Properties of Poly(lactic) Acid Reinforced with Carbon-Based Particles: Experimental Study and Design Theory

et al. 2020

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In the present study, polylactic acid (PLA) enriched with carbonaceous particles like multi-walled carbon nanotubes (MWCNTs), graphene nanoplates (GNPs) or a combination of both up 12 wt % of loading are used for producing 3D-printed specimens with fused deposition modeling (FDM) technology which are then experimentally and theoretically investigated. The goal is to propose a non-conventional filaments indicated for additive manufacturing process with improved dielectric and thermal properties, compared to the performances exhibited by the unfilled polymer. In the light of the above, a wide dielectric spectroscopy and a thermal analysis, supported by a morphological investigation, are performed. The results highlight that the introduction of 1-dimensional filler (MWCNTs) are more suitable for improving the dielectric properties of the resulting materials, due to the enhancement of the interfacial polarization and the presence of functionalized groups, whereas 2-dimensional nanoparticles (GNPs) better favor the thermal conduction mechanisms thanks to the lower thermal boundary resistance between the two phases, polymer/filler. In particular, with a loading of 12 wt % of MWCNTs the relative permittivity reaches the value of 5.35 × 103 much greater than that of 3.7 measured for unfilled PLA while for the thermal conductivity the enhancement with 12 wt % of GNPs is about 261% respect the thermal behavior of the neat polymer. The experimental results are correlated to theoretical findings, whereas a design of experiment (DoE) approach is adopted for investigating how the different fillers influence the dielectric and thermal performances of the 3D-printed parts, thus assisting the design of such innovative materials that appear promising for development and applications in the electromagnetic (EM) field and heat transfer.

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“…In these cases, most common therapy techniques are permanent implants or implantation of bone grafts. The main drawbacks of the commonly applied methods in bone surgery include corrosion and cytotoxicity of metallic objects, shortage of donors, wearing of synthetic materials, and risk of infection in transplantation cases [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of the novel 80S bioactive glass: bioactivity, ‎biocompatibility, cytotoxicity

Bakhtiari

Cheshmi

Naeimi

et al. 2020

jcc

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In this research, the 80S bioactive glass with different Ca/P ratios was prepared by the sol-gel route. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), and Fourier transforms infrared spectroscopy (FTIR) were used to study the apatite structure and shape. According to the results, the 78SiO2-17P2O5-5CaO bioglass showed a higher rate of crystalline hydroxyapatite (HA) on its surface in comparison with the other bioglasses. After 3 days of immersion in the SBF solution, spherical apatite was formed on the 78SiO2-17P2O5-5CaO surface, which demonstrated high bioactivity. A statistically significant promotion in proliferation and differentiation of G292 osteoblastic cells was also observed. Regarding its optimal cell viability and bioactivity, the 78SiO2-17P2O5-5CaO bioactive glass could be offered as a promising candidate for bone tissue applications.

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Fabrication, multi-scale characterization and in-vitro evaluation of porous hybrid bioactive glass polymer-coated scaffolds for bone tissue engineering

Cited by 22 publications

References 69 publications

The Effect of Bioactive Glass-Enhanced Orthodontic Bonding Resins on Prevention of Demineralization: A Systematic Review

The Effect of Bioactive Glass-Enhanced Orthodontic Bonding Resins on Prevention of Demineralization: A Systematic Review

Dielectric Spectroscopy and Thermal Properties of Poly(lactic) Acid Reinforced with Carbon-Based Particles: Experimental Study and Design Theory

Synthesis and characterization of the novel 80S bioactive glass: bioactivity, ‎biocompatibility, cytotoxicity

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