Fabrication, microstructure characterization, and degradation performance of electrospun mats based on poly(3‐hydroxybutyrate‐co‐3 hydroxyvalerate)/polyethylene glycol blend for potential tissue engineering

Abstract

There have been strong demands for nanofibrous scaffolds fabricated by electrospinning for various fields due to their various advantages. Electrospun poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) fibre mats were prepared. The effects of processing variables as well as the inclusion of poly(ethylene glycol) (PEG) on the morphologies of generated fibres were investigated using Fourier-transform infrared spectroscopy and scanning electron microscopy. The average fibrous diameter was monitored in the range 400-3000 nm relying on the total content of PEG.The fluorescence cell imaging of electrospun mats was also explored. The results of cell viability demonstrated that skin fibroblast BJ-1 cells showed different adhesions and growth rates for the three kinds of PHBV fibres. Electrospun PHBV mats with low amount of PEG offer a high-quality medium for cell growth. Therefore, those mats exhibited high potential for soft tissue engineering, in particular wound healing.

Biomedical Applications of the Biopolymer Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV): Drug Encapsulation and Scaffold Fabrication

“…They found that the cutaneous fibroblasts BJ-1 showed different adhesions and growth rates on the different types of PHBV fibers. The result indicated that PHBV mats with a low amount of PEG have a high potential for use in soft-tissue engineering, particularly in wound-healing applications [91]. In another publication, the authors designed an electrospun core-sheath mat made of polydioxanone (PDX) and PHBV.…”

Fermentative bioconversion of food waste into biopolymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate) using Cupriavidus necator

“…In our knowledge, this is the first study to produce PHBV biopolymer though valorisation of collected cooked food waste. At the same time, electrospinning and electrospraying techniques appear promising prospects to address the shortage of bioplastics for medical and industrial applications by utilization of the PHBV biopolymer produced in this study (El-Newehy et al, 2021;Kaniuk & Stachewicz, 2021). and.…”