Fabrication, evolution, and mutual conversion of D-fucose-activatable and -repressible acetyltransferase upon mutations
Yuki Yanai,
Miyu Tsukada,
Yuki Kimura
et al.
Abstract:The fusion of different proteins can result in the linkage-dependent emergence of molecular switches. In cases where allosteric regulation is designed between the input and output modules of fusion proteins, it is hard to predict whether on-switching or off-switching will occur. However, binding-induced folding, a non-allosteric molecular switch mechanism, has the potential to quickly establish a mutually regulatory relationship between the two fused proteins, in the way whether on-switching or off-switching w… Show more
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