Fabrication, characterization, and interventions of protein, polysaccharide and lipid-based nanoemulsions in food and nutraceutical delivery applications: A review

Manzoor, Mehnaza; Sharma, Priyanshu; Murtaza, Mohd; Jaiswal, Amit K.; Jaglan, Sundeep

doi:10.1016/j.ijbiomac.2023.124485

Cited by 12 publications

(6 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An efficient way to incorporate lipophilic compounds into hydrogel matrices is through the use of nanoemulsions. Direct oil-in-water (O/W) nanoemulsions can incorporate hydrophobic substances in the dispersed phase of the nanoemulsion [ 46 , 47 , 48 , 49 ]. This nanoemulsion is incorporated into the aqueous mixture of the hydrogel before its gelation, so that cross-linking of the molecules occurs in the continuous phase of the nanoemulsion and the hydrogel is formed with the oil droplets inside its matrix.…”

Section: Introductionmentioning

confidence: 99%

“…Among the best-known oils are carvacrol, thymol, eugenol, linalool, cinnamaldehyde, D-limonene, etc. Each of these is mostly found in a different plant and has different characteristics and properties [ 45 , 46 , 47 , 48 , 49 , 50 ]. Carvacrol has been proven to be one of the essential oils with the strongest antimicrobial and antioxidant properties.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Rheological Study of the Formation of Pullulan Hydrogels and Their Use as Carvacrol-Loaded Nanoemulsion Delivery Systems

Santamaría

Barros

González

et al. 2023

Gels

View full text Add to dashboard Cite

Hydrogels have been extensively studied as delivery systems for lipophilic compounds. Pullulan hydrogels were prepared, and their gelation kinetics were studied over time. Pullulan exhibited a relatively slow gelling reaction in basic medium (KOH) using trisodium metaphosphate (STMP) as a cross-linking agent, so capsules cannot be obtained by dripping as easily as in the case of alginate and chitosan. The kinetics of pullulan gelation were studied through rheological analysis over time. An optimal [Pullulan]/[KOH] ratio was found for a fixed [Pullulan]/[STMP] ratio. For this given relationship, gelling time measurements indicated that when the concentration of pullulan increased, the gelation time decreased from 60 min for 6% w/w pullulan to 10 min for 10% w/w. After the gel point, a hardening of the hydrogel was observed over the next 5 h. The formed hydrogels presented high degrees of swelling (up to 1800%). Freeze-dried gels were capable of being rehydrated, obtaining gels with rheological characteristics and visual appearance similar to fresh gels, which makes them ideal to be freeze-dried for storage and rehydrated when needed. The behavior of the hydrogels obtained as active ingredient release systems was studied. In this case, the chosen molecule was carvacrol (the main component of oregano oil). As carvacrol is hydrophobic, it was incorporated into the droplets of an oil-in-water nanoemulsion, and the nanoemulsion was incorporated into the hydrogel. The release of the oil was studied at different pHs. It was observed that as the pH increased (from pH 2 to pH 7), the released amount of carvacrol for the gel with pullulan 10% w/w reached 100%; for the other cases, the cumulative release amount was lower. It was attributed to two opposite phenomena in the porous structure of the hydrogel, where more porosity implied a faster release of carvacrol but also a higher degree of swelling that promoted a higher entry of water flow in the opposite direction. This flow of water prevented the active principle from spreading to the release medium.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rheological Study of the Formation of Pullulan Hydrogels and Their Use as Carvacrol-Loaded Nanoemulsion Delivery Systems

Santamaría

Barros

González

et al. 2023

Gels

View full text Add to dashboard Cite

show abstract

“…Developing drug carriers based on lipid nanoemulsions offers promising prospects but also carries potential challenges that require further research. Nanoemulsions can be susceptible to destabilization associated with storage conditions, which affects their structural integrity and ability to effectively deliver drugs [74,75]. Controlling particle size and distribution in nanoemulsions is a key aspect that affects their stability and bioavailability [76].…”

Section: Lipid Nanoemulsionsmentioning

confidence: 99%

“…tural integrity and ability to effectively deliver drugs [74,75]. Controlling particle size a distribution in nanoemulsions is a key aspect that affects their stability and bioavailabi [76].…”

Section: Solid Lipid Nanoparticles (Slns) and Nanostructured Lipid Ca...mentioning

confidence: 99%

Advanced Drug Carriers: A Review of Selected Protein, Polysaccharide, and Lipid Drug Delivery Platforms

Jamroży,

Kudłacik-Kramarczyk,

Drabczyk

et al. 2024

IJMS

View full text Add to dashboard Cite

Studies on bionanocomposite drug carriers are a key area in the field of active substance delivery, introducing innovative approaches to improve drug therapy. Such drug carriers play a crucial role in enhancing the bioavailability of active substances, affecting therapy efficiency and precision. The targeted delivery of drugs to the targeted sites of action and minimization of toxicity to the body is becoming possible through the use of these advanced carriers. Recent research has focused on bionanocomposite structures based on biopolymers, including lipids, polysaccharides, and proteins. This review paper is focused on the description of lipid-containing nanocomposite carriers (including liposomes, lipid emulsions, lipid nanoparticles, solid lipid nanoparticles, and nanostructured lipid carriers), polysaccharide-containing nanocomposite carriers (including alginate and cellulose), and protein-containing nanocomposite carriers (e.g., gelatin and albumin). It was demonstrated in many investigations that such carriers show the ability to load therapeutic substances efficiently and precisely control drug release. They also demonstrated desirable biocompatibility, which is a promising sign for their potential application in drug therapy. The development of bionanocomposite drug carriers indicates a novel approach to improving drug delivery processes, which has the potential to contribute to significant advances in the field of pharmacology, improving therapeutic efficacy while minimizing side effects.

show abstract

“…Among them, nanoemulsions (NEs) are regarded as heterogeneous colloidal mixtures of oily and aqueous phases associated with a surfactant adsorbed at the interface between both phases. Such surfactants can help decrease the surface tension and enhance the system’s stability [ 27 ]. As efficacious delivery systems, NEs can exhibit several merits, including great solubilization capacity, high drug loading, controlled drug release profiles, and the potential delivery of lipophilic drugs.…”

Section: Introductionmentioning

confidence: 99%

Optimization of Potential Nanoemulgels for Boosting Transdermal Glimepiride Delivery and Upgrading Its Anti-Diabetic Activity

Abdallah

Lila

El-Nahas

et al. 2023

Gels

View full text Add to dashboard Cite

Transdermal drug delivery has been widely adopted as a plausible alternative to the oral route of administration, especially for drugs with poor systemic bioavailability. The objective of this study was to design and validate a nanoemulsion (NE) system for transdermal administration of the oral hypoglycemic drug glimepiride (GM). The NEs were prepared using peppermint/bergamot oils as the oil phase and tween 80/transcutol P as the surfactant/co-surfactant mixture (Smix). The formulations were characterized using various parameters such as globule size, zeta potential, surface morphology, in vitro drug release, drug-excipient compatibility studies, and thermodynamic stability. The optimized NE formulation was then incorporated into different gel bases and examined for gel strength, pH, viscosity, and spreadability. The selected drug-loaded nanoemulgel formulation was then screened for ex vivo permeation, skin irritation, and in vivo pharmacokinetics. Characterization studies revealed the spherical shape of NE droplets with an average size of ~80 nm and a zeta potential of −11.8 mV, which indicated good electrokinetic stability of NE. In vitro release studies revealed enhanced drug release from the NE formulation compared to the plain drug. GM-loaded nanoemulgel showed a 7-fold increment in drug transdermal flux compared to plain drug gel. In addition, the GM-loaded nanoemulgel formulation did not elicit any signs of inflammation and/or irritation on the applied skin, suggesting its safety. Most importantly, the in vivo pharmacokinetic study emphasized the potential of nanoemulgel formulation to potentiate the systemic bioavailability of GM, as manifested by a 10-fold rise in the relative bioavailability compared to control gel. Collectively, transdermal NE-based GM gel might represent a promising alternative to oral therapy in the management of diabetes.

show abstract

Fabrication, characterization, and interventions of protein, polysaccharide and lipid-based nanoemulsions in food and nutraceutical delivery applications: A review

Cited by 12 publications

References 65 publications

Rheological Study of the Formation of Pullulan Hydrogels and Their Use as Carvacrol-Loaded Nanoemulsion Delivery Systems

Rheological Study of the Formation of Pullulan Hydrogels and Their Use as Carvacrol-Loaded Nanoemulsion Delivery Systems

Advanced Drug Carriers: A Review of Selected Protein, Polysaccharide, and Lipid Drug Delivery Platforms

Optimization of Potential Nanoemulgels for Boosting Transdermal Glimepiride Delivery and Upgrading Its Anti-Diabetic Activity

Contact Info

Product

Resources

About