Fabrication, Characterization, and Insecticidal Activity Evaluation of Emamectin Benzoate–Sodium Lignosulfonate Nanoformulation with pH-Responsivity

Cui, Jianguo; Mo, Dongmei; Yang, Jian; Gan, Chunfang; Wei-guo, LI; Ai, Wu; Li, Xiang-Ying; Xiao, Jun‐An; Hu, Qiang; Yuan, Haiyan; Lu, Rui; Huang, Yanmin

doi:10.1021/acs.iecr.9b03171

Cited by 27 publications

(24 citation statements)

References 46 publications

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“…To corroborate and elaborate this aspect, the influence of the pH on the medium for the free porphyrins and the encapsulated porphyrins was analyzed. In the literature, there are some examples where drug-loaded lignin nanoparticles are able to release their cargo into the media, in acidic pH [ 41 , 42 , 43 , 44 ]. However, porphyrins loaded into acetylated lignin nanoparticles seem to be unaltered when the pH of the media fluctuates [ 20 ], and this could be due to a diminishing of the accessibility of the solvent during acetylated lignin nanoparticles formation [ 40 ], which could eventually lead to the permanent entrapment of porphyrins inside nanoparticles.…”

Section: Resultsmentioning

confidence: 99%

“…The lack of interaction between the medium and the encapsulated porphyrins could mean that the porphyrins are not released into the media, even when a pH change occurs. In the literature, there are reports that indicate that lignin nanoparticles loaded with benzazulene [ 41 , 42 ], sorafenib [ 42 ], 10-hydroxycamptothecin [ 43 ] and emamectin benzoate [ 44 ] are able to release their cargo in acidic pH. Furthermore, some reports indicate that release happens even at neutral pH, but is enhanced in acidic pH [ 41 ].…”

Section: Resultsmentioning

confidence: 99%

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Photophysical and Antibacterial Properties of Porphyrins Encapsulated inside Acetylated Lignin Nanoparticles

et al. 2021

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Lignin has recently attracted the attention of the scientific community, as a suitable raw material for biomedical applications. In this work, acetylated lignin was used to encapsulate five different porphyrins, aiming to preserve their photophysical properties, and for further use as antibacterial treatment. The obtained nanoparticles were physically characterized, through dynamic light scattering size measurement, polydispersity index and zeta potential values. Additionally, the photophysical properties of the nanoparticles, namely UV-vis absorption, fluorescence emission, singlet oxygen production and photobleaching, were compared with those of the free porphyrins. It was found that all the porphyrins were susceptible to encapsulation, with an observed decrease in their fluorescence quantum yield and singlet oxygen production. These nanoparticles were able to exert an effective photodynamic bactericide effect (blue-LED light, 450–460 nm, 15 J/cm2) on Staphylococcus aureus and Escherichia coli. Furthermore, it was achieved a photodynamic bactericidal activity on an encapsulated lipophillic porphyrin, where the free porphyrin failed to diminish the bacterial survival. In this work it was demonstrated that acetylated lignin encapsulation works as a universal, cheap and green material for the delivery of porphyrins, while preserving their photophysical properties.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Photophysical and Antibacterial Properties of Porphyrins Encapsulated inside Acetylated Lignin Nanoparticles

et al. 2021

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“…This solubility is not enough in field applications, especially in premix and drone spraying, which requires very high concentrations. As for the photosensitivity problem, photoprotectants have been used to protect EMB from UV damage 9,10 and this strategy is successful when photoprotectants are combined with organic solvents. However, once the use of organic solvents is reduced or removed, the protection would decrease significantly due to phase separation.…”

Section: Introductionmentioning

confidence: 99%

Nano‐EMB‐SP improves the solubility, foliar affinity, photostability and bioactivity of emamectin benzoate

Gao

Cui

Wang

et al. 2022

Pest Management Science

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BACKGROUND: Emamectin benzoate (EMB), a frequently used biopesticide, is poorly soluble in water, making it difficult to wet the leaf surface, is prone to degrade in sunlight and readily loses its bioactivity. Traditional methods such as organic solvent application, pH adjustment and addition of photoprotectants either increase the economic and environmental costs or barely achieve the desired goal. We hypothesized that nanotechnology could improve the solubility, foliar affinity, photostability and bioactivity of EMB. This research set out to prepare a nano-EMB solid powder (nano-EMB-SP) and test this hypothesis.RESULTS: Nano-EMB-SP was prepared using a self-emulsifying method combined with carrier solidification. The mean particle size and Polydispersity index (PDI) of nano-EMB-SP were 14.64 nm and 0.24, respectively. A scanning electron microscopy image showed that EMB nanoparticles were mainly spherical or ellipsoidal in shape. Without organic solvent, the aqueous solubility of EMB in nano-EMB-SP was 4500 mg L −1 , at least 14-fold that of the EMB soluble granule (EMB-SG), which is solubilized by pH adjustment. Excellent foliar affinity of EMB was achieved by nano-EMB-SP, which completely wet and penetrated the superhydrophobic surface of cabbage (Brassica oleracea L.) leaf. Without photoprotectants, up to 82% of EMB content can be protected from ultraviolet (UV) damage in nano-EMB-SP. The combined effects of excellent photostability and foliar affinity of nano-EMB-SP led to the bioactivity of EMB being almost unchanged before and after UV radiation.CONCLUSION: Nano-EMB-SP is an eco-friendly and efficient way to improve the solubility, foliar affinity, photostability and bioactivity of EMB. This research provides a good approach to improving the efficacy of poorly soluble and UV-sensitive pesticides.

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“…The application of pesticides in agriculture could increase crop production by 30%, which is one of the most important ways to increase agricultural production, and play an important role in ensuring global grain production . However, 90% of the pesticides decompose or are released into the environment before reaching the crops, which weakens the killing effect of pesticides and leads to resistance in pests and lower agricultural yields. − In addition, pesticides not only pollute the environment but also may enter the human body via the food chain and have potentially adverse effects on human health. , In this context, to reduce the number of chemical pesticides used, the development of controlled release technology for pesticides and sustainable agriculture is becoming more attractive to researchers. − …”

Section: Introductionmentioning

confidence: 99%

Basic Amino Acid-Modified Lignin-Based Biomass Adjuvants: Synthesis, Emulsifying Activity, Ultraviolet Protection, and Controlled Release of Avermectin

et al. 2021

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Avermectin (AVM) is a highly effective and safe biopesticide but is very sensitive to ultraviolet (UV) light and exhibits poor water solubility. Developing green and multifunctional adjuvants is important for the protection and controlled release of AVM. In this work, a number of water-soluble enzymatic hydrolysis lignins (W-EHLs) were prepared via grafting basic amino acids and used as emulsifiers with co-surfactants to prepare high-internal phase emulsions (HIPEs). The results showed that W-EHLs with co-surfactants could be prepared with HIPEs that contained 90 vol % green oil phases such as turpentine, and the stability of the HIPEs first increased and then decreased when the rate of grafting of basic amino acids on lignin increased from 0.26 to 1.46 mmol/g. The more polar oil droplets were less deformable due to their higher viscosity, thereby affording a stability advantage to HIPEs. Subsequently, the relations between the stability and interfacial viscoelasticity of the emulsion were effectively correlated by interfacial rheology, droplet size, and physical stability tests. The results showed that HIPEs with smaller droplets had poor fluidity and strong interfacial viscoelasticity due to their higher droplet packing density, which resulted in good macroscopic stability. Like the AVM carrier, the retention rate of AVM in HIPEs was 80.1% after UV radiation for 72 h, which represented the highest UV protection efficiency in AVM delivery systems. The release curves showed that the rate of release of AVM from HIPEs was adjusted by controlling the pH value of the medium. In addition, the release of HIPEs is completely in accord with both diffusion and the matrix erosion mechanism. The strategy could be extended to other sensitive pesticides and used to promote the development of sustainable agriculture.

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Fabrication, Characterization, and Insecticidal Activity Evaluation of Emamectin Benzoate–Sodium Lignosulfonate Nanoformulation with pH-Responsivity

Cited by 27 publications

References 46 publications

Photophysical and Antibacterial Properties of Porphyrins Encapsulated inside Acetylated Lignin Nanoparticles

Photophysical and Antibacterial Properties of Porphyrins Encapsulated inside Acetylated Lignin Nanoparticles

Nano‐EMB‐SP improves the solubility, foliar affinity, photostability and bioactivity of emamectin benzoate

Basic Amino Acid-Modified Lignin-Based Biomass Adjuvants: Synthesis, Emulsifying Activity, Ultraviolet Protection, and Controlled Release of Avermectin

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