Fabrication, characterization and antimicrobial activities of thymol-loaded zein nanoparticles stabilized by sodium caseinate–chitosan hydrochloride double layers

Sodium deoxycholate-decorated zein nanoparticles for a stable colloidal drug delivery system

“…17 However, due to their low net charge close to the isoelectric point (pI ≈6.2), the poor physical stability and dispersibility of freeze-dried zein nanoparticles at a neutral pH are detrimental to an efficacious application of this material in the alimentary and pharmaceutical fields. 18 In this attempt, sodium caseinate, 19 lecithin, Pluronic F68 ® , 20 and Tween 20 ® were used as stabilizers to prevent the colloidal aggregation of zein-based nanosystems by decreasing their hydrophobic attraction and increasing steric repulsion. [20][21][22][23] The aim of this investigation was to evaluate the influence of several factors on the preparation of stable zein nanoparticles made up of yellow derivative, in order to develop a colloidal formulation useful for drug delivery.…”

Core–shell biopolymer nanoparticle delivery systems: Synthesis and characterization of curcumin fortified zein–pectin nanoparticles

“…However, zein particles often have poor stability to aggregation when exposed to environmental conditions commonly encountered in food and pharmaceutical products, such as certain pH ranges, high salt contents, and (Patel et al, 2010). Zein-biopolymer nanoparticles have already been used to encapsulate a variety of lipophilic bioactives, including a-tocopherol , vitamin D 3 (Luo, Teng, & Wang, 2012), and thymol (Zhang et al, 2014). In this study, we focus on the utilization of an anionic polysaccharide to coat and stabilize zein nanoparticles since this type of biopolymer is already widely used as a functional ingredient in the food industry.…”

Continuous microfluidic production of zein nanoparticles and correlation of particle size with physical parameters determined using CFD simulation

“…Zein belongs to the prolamin group of corn proteins, meaning it is insoluble in water, but soluble in a 71 binary mixture of water and ethanol (Chen and Zhong, 2014; Kim and Xu, 2008;Zhang et al, 2014). This 72 is due to the large fraction of hydrophobic amino acid residues found in zein (Chen and Zhong, 2015).…”