Fabrication, characteristics, and applications of boron nitride and their composite nanomaterials

Hayat, Asif; Sohail, Muhammad; Hamdy, Mohamed S.; Taha, T.A.; AlSalem, Huda S.; Alenad, Asma M.; Amin, Mohammed A.; Shah, Rahim; Palamanit, Arkom; Khan, Javid; Nawawi, W.I.; Mane, Sunil Kumar Baburao

doi:10.1016/j.surfin.2022.101725

Cited by 42 publications

(25 citation statements)

References 223 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In previous studies, an hBN thin film was successfully synthesized on different substrates such as silicon and sapphire by low-pressure chemical vapor deposition [ 39 , 40 ]. Moreover, it was shown that the functionalization of BN by incorporating with FA has an excellent advantage as a drug delivery system [ 41 , 42 ]. A previous study showed that folate-conjugated boron nitride nanotubes can be used as a boron carrier for boron neutron capture therapy (BNCT) in cerebral glioblastoma multiforme.…”

Section: Discussionmentioning

confidence: 99%

Boron Nitride Nanoparticles Loaded with a Boron-Based Hybrid as a Promising Drug Carrier System for Alzheimer’s Disease Treatment

Çağlar

Arslan

Öner

et al. 2022

IJMS

View full text Add to dashboard Cite

The search for an innovative and effective drug delivery system that can carry and release targeted drugs with enhanced activity to treat Alzheimer’s disease has received much attention in the last decade. In this study, we first designed a boron-based drug delivery system for effective treatment of AD by integrating the folic acid (FA) functional group into hexagonal boron nitride (hBN) nanoparticles (NPs) through an esterification reaction. The hBN-FA drug carrier system was assembled with a new drug candidate and a novel boron-based hybrid containing an antioxidant as BLA, to constitute a self-assembled AD nano transport system. We performed molecular characterization analyses by using UV-vis spectroscopy, Fourier transform infrared spectrophotometer (FTIR), scanning electron microscope (SEM), Energy-dispersive X-ray spectroscopy (EDS) and Zeta potential investigations. Second, we tested the anti-Alzheimer properties of the carrier system on a differentiated neuroblastoma (SHSY5-Y) cell line, which was exposed to beta-amyloid (1–42) peptides to stimulate an experimental in vitro AD model. Next, we performed cytotoxicity analyses of synthesized molecules on the human dermal fibroblast cell line (HDFa) and the experimental AD model. Cytotoxicity analyses showed that even higher concentrations of the carrier system did not enhance the toxicological outcome in HDFa cells. Drug loading analyses reported that uncoated hBN nano conjugate could not load the BLA, whereas the memantine loading capacity of hBN was 84.3%. On the other hand, memantine and the BLA loading capacity of the hBN-FA construct was found to be 95% and 97.5%, respectively. Finally, we investigated the neuroprotective properties of the nano carrier systems in the experimental AD model. According to the results, 25 µg/mL concentrations of hBN-FA+memantine (94% cell viability) and hBN-FA+BLA (99% cell viability) showed ameliorative properties against beta-amyloid (1–42) peptide toxicity (50% cell viability). These results were generated through the use of flow cytometry, acetylcholinesterase (AChE) and antioxidant assays. In conclusion, the developed drug carrier system for AD treatment showed promising potential for further investigations and enlightened neuroprotective capabilities of boron molecules to treat AD and other neurodegenerative diseases. On the other hand, enzyme activity, systematic toxicity analyses, and animal studies should be performed to understand neuroprotective properties of the designed carrier system comprehensively.

show abstract

Section: Discussionmentioning

confidence: 99%

Boron Nitride Nanoparticles Loaded with a Boron-Based Hybrid as a Promising Drug Carrier System for Alzheimer’s Disease Treatment

Çağlar

Arslan

Öner

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…54 h-BN displays high chemical stability, thermal stability, electrical properties, tunable solubility, high-temperature lubricating properties, and gas adsorption properties. 54–56 These days, boron nitride-based composites are also gaining much research interest due to improved properties than h-BN. In 1995, Chopra et al synthesized boron nitride nanotubes (BNNTs) for the first time.…”

Section: B–c–n Materialsmentioning

confidence: 99%

Recent insights into BCN nanomaterials – synthesis, properties and applications

et al. 2023

View full text Add to dashboard Cite

show abstract

“…fuel energy and the same for water splitting reaction. [29][30][31][32] An appealing photocatalyst with a reasonably high conductance band (CB) and valence band (VB) can be used to promote such a photocatalytic process. More than a hundred materials have been presented, thus far to be the catalysts for photocatalytic CO 2 reduction and water splitting.…”

Section: Introductionmentioning

confidence: 99%

Recent Advancement of the Current Aspects of g‐C₃N₄for its Photocatalytic Applications in Sustainable Energy System

Hayat

Sohail

Syed

et al. 2022

The Chemical Record

Self Cite

View full text Add to dashboard Cite

Being one of the foremost enticing and intriguing innovations, heterogeneous photocatalysis has also been used to effectively gather, transform, and conserve sustainable sun‘s radiation for the production of efficient and clean fossil energy as well as a wide range of ecological implications. The generation of solar fuel‐based water splitting and CO2 photoreduction is excellent for generating alternative resources and reducing global warming. Developing an inexpensive photocatalyst can effectively split water into hydrogen (H2), oxygen (O2) sources, and carbon dioxide (CO2) into fuel sources, which is a crucial problem in photocatalysis. The metal‐free g‐C3N4 photocatalyst has a high solar fuel generation potential. This review covers the most recent advancements in g‐C3N4 preparation, including innovative design concepts and new synthesis methods, and novel ideas for expanding the light absorption of pure g‐C3N4 for photocatalytic application. Similarly, the main issue concerning research and prospects in photocatalysts based g‐C3N4 was also discussed. The current dissertation provides an overview of comprehensive understanding of the exploitation of the extraordinary systemic and characteristics, as well as the fabrication processes and uses of g‐C3N4.

show abstract

Fabrication, characteristics, and applications of boron nitride and their composite nanomaterials

Cited by 42 publications

References 223 publications

Boron Nitride Nanoparticles Loaded with a Boron-Based Hybrid as a Promising Drug Carrier System for Alzheimer’s Disease Treatment

Boron Nitride Nanoparticles Loaded with a Boron-Based Hybrid as a Promising Drug Carrier System for Alzheimer’s Disease Treatment

Recent insights into BCN nanomaterials – synthesis, properties and applications

Recent Advancement of the Current Aspects of g‐C₃N₄for its Photocatalytic Applications in Sustainable Energy System

Contact Info

Product

Resources

About

Fabrication, characteristics, and applications of boron nitride and their composite nanomaterials

Cited by 42 publications

References 223 publications

Boron Nitride Nanoparticles Loaded with a Boron-Based Hybrid as a Promising Drug Carrier System for Alzheimer’s Disease Treatment

Boron Nitride Nanoparticles Loaded with a Boron-Based Hybrid as a Promising Drug Carrier System for Alzheimer’s Disease Treatment

Recent insights into BCN nanomaterials – synthesis, properties and applications

Recent Advancement of the Current Aspects of g‐C3N4for its Photocatalytic Applications in Sustainable Energy System

Contact Info

Product

Resources

About

Recent Advancement of the Current Aspects of g‐C₃N₄for its Photocatalytic Applications in Sustainable Energy System