Fabrication, biological effects, and medical applications of calcium phosphate nanoceramics

Hong, Youliang; Fan, Hongsong; Li, Bo; Guo, Bo; Liu, Ming; Zhang, Xingdong

doi:10.1016/j.mser.2010.06.010

Cited by 178 publications

(157 citation statements)

References 174 publications

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“…By means of these methods, a variety of nanodimensional calcium orthophosphate building blocks with various structures and morphologies have been synthesized, including needle-like, spherical, fibrous and mesoporous nano-sized crystals, as well as nano-sized rods, hollow spheres, layered structures and flowers as shown in Fig. 6 [452]. Table 3 presents some data on the chronological development of synthesis of nanodimensional apatites for the period of 1995 -2004 [147].…”

Section: Nanodimensional and Nanocrystalline Apatitesmentioning

confidence: 99%

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Dorozhkin¹

2012

AJBE

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Nano-sized particles and crystals play an important role in the formation of calcified tissues of various animals. For example, nano-sized and nanocrystalline calcium orthophosphates in the form of apatites of biological origin represent the basic inorganic building blocks of bones and teeth of mammals. Namely, according the recent developments in biomineralization, tens to hundreds nanodimensional crystals of a biological apatite are self-assembled into these complex structures. This process occurs under a strict control by bioorganic matrixes. Furthermore, both a greater viability and a better proliferation of various types of cells have been detected on smaller crystals of calcium orthophosphates. Thus, the nano-sized and nanocrystalline forms of calcium orthophosphates have a great potential to revolutionize the hard tissue-engineering field, starting from bone repair and augmentation to controlled drug delivery systems. This review reports on current state of the art and recent developments on the subject, starting from synthesis and characterization to biomedical and clinical applications. Furthermore, the review also discusses possible directions for future research and development.

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Section: Nanodimensional and Nanocrystalline Apatitesmentioning

confidence: 99%

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Dorozhkin¹

2012

AJBE

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“…Estudos in vitro e in vivo demonstraram que fosfatos de cálcio porosos nanoestruturados apresentam maior bioatividade, especialmente maior osteoindutividade do que os convencionais, sugerindo que quanto menores forem os grânulos e mais porosidades tiverem, melhor será sua atividade na neoformação óssea (Hong et al 2010).…”

Section: Discussionunclassified

“…Estas vantagens estruturais demonstram melhor bioatividade, solubilidade e biodegradabilidade destes biomateriais quando aplicados in vivo e/ou em meio simulado (Hong et al 2010).…”

Section: Introductionunclassified

Neoformação óssea e osteointegração de biomateriais micro e nanoestruturados em ovinos

et al. 2015

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Bone replacement is often required in veterinary clinics and hospitals routine, even because fractures, bone tumors or any orthopedic disease that entail in bone loss. In this sense, biomaterials capable of promoting this substitution, avoiding the use of bone grafts or transplants have been searched. The aim of this study was evaluated the osteoregenerative capacity of biomaterials in different compositions, implanted in sheep's tibia. Eight female, mongrel sheeps, 12 months old, weighting 28,5±7,4kg were obtained for this study. Three bone defects, 6mm each, in both tibias, a total of six bone defects, were produced, being four of them treated with four different types of biomaterials and two with autogenous bone grafts, as a control group. The biomaterials implanted were: hydroxyapatite (HA), beta-tricalcium phosphate (TCP-β), hydroxyapatite/beta-tricalcium phosphate 60:40 (HA/TCP-β 60:40) and the nanocomposite hydroxyapatite and alumina (HA/Al 2 O 3 5%). The animals were allocated in two groups: Group 60 (n=04), in which the animals were euthanized sixty days after the implantation of the biomaterials and Group 90 (n=04), in which the animals were euthanized ninety days after the procedure. Were performed radiograph images on the preoperative period, immediate postoperative and at 30, 60 and 90 days of postoperative period, to excluded any previously disease or postoperative complications that could compromise this research. After euthanasia, the tibias were collected for macro and microscopic evaluation, which was accessed by scanning electron microscopy (SEM) and optic microscopy. The results suggest that HA, TCP-β and HA/TCP-β present a great osteoregenerative capacity. The last one seems to be better for a long-term outcome, due its best control in the solubilization and releasing of calcium and phosphates ions through the biological environment during bone formation. The nanocomposite HA/Al 2 O 3 5% didn't show a good response on this study, and we suggest new researches to better evaluate the potential and applicability of this new biomaterial. We concluded that HA, TCP-β and HA/TCP-β 60:40 presented excellent capacity of bone repair, and could be used as bone substituts; the association HA/TCP-β (60:40) is superior due his intermediary velocity of absortion comparing to HA and TCP-β isolated, providing adequate supporting to the neoformed tissue; the HA/Al 2 O 3 5% showed incompatibility, 1 Recebido em 26 de junho de 2014.Aceito para publicação em 21 de dezembro de 2014.

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“…The surface structural characteristic determines the type of the adsorbed protein, and its conformation also further changes to specific cell adhesion, and then affects cell behavior. For example, Zhang's group showed that nano-biphasic calcium phosphate ceramic is able to selectively adsorb more low molecular weight of lysozyme (LSZ) in lysozyme/bovine serum albumin (BSA) protein system than conventional ceramics, which can significantly up-regulate the osteoblaste upstream gene of BMP2 in osteogenic cells in vitro, and induce more bone tissue in animal body [19].…”

Section: Biomaterials For Tissue Induction and Protein Adsorptionmentioning

confidence: 99%