Fabrication and testing of a miniature cylindrical ion trap mass spectrometer constructed from low temperature co-fired ceramics

Chaudhary, Anita; Amerom, F. H. W. van; Short, R.T.; Bhansali, Shekhar

doi:10.1016/j.ijms.2005.12.013

Cited by 68 publications

(56 citation statements)

References 23 publications

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“…Among them, Cooks at Purdue University has successfully integrated 106 miniaturized cylindrical ion traps with an inner diameter of 1 µm into a chip using the technologies of tungsten inlay and chemical vapourdeposition. 11,12 Most researches on MEMS ion traps are based on linear and cylindrical ion traps 13,14 and only a few are based on the rectilinear ion traps, which have larger ion capacity. In addition, in the a Electronic mail: tangf@mail.tsinghua.edu.cn.…”

Section: -4mentioning

confidence: 99%

Optimization and simulation of MEMS rectilinear ion trap

et al. 2014

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In this paper, the design of a MEMS rectilinear ion trap was optimized under simulated conditions. The size range of the MEMS rectilinear ion trap’s electrodes studied in this paper is measured at micron scale. SIMION software was used to simulate the MEMS rectilinear ion trap with different sizes and different radio-frequency signals. The ion-trapping efficiencies of the ion trap under these different simulation conditions were obtained. The ion-trapping efficiencies were compared to determine the performance of the MEMS rectilinear ion trap in different conditions and to find the optimum conditions. The simulation results show that for the ion trap at micron scale or smaller, the optimized length–width ratio was 0.8, and a higher frequency of radio-frequency signal is necessary to obtain a higher ion-trapping efficiency. These results have a guiding role in the process of developing MEMS rectilinear ion traps, and great application prospects in the research fields of the MEMS rectilinear ion trap and the MEMS mass spectrometer.

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Section: -4mentioning

confidence: 99%

Optimization and simulation of MEMS rectilinear ion trap

et al. 2014

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“…In another study, the ring electrodes (r 0 ¼ 1.375 mm) of CITs were fabricated from low temperature co-fired ceramics (LTCC), and areas to be metallized were patterned photolithographically, which enabled easy batch fabrication (Chaudhary et al, 2006). The endplates were made of stainless steel.…”

Section: A Ion Trapsmentioning

confidence: 99%

Microchip technology in mass spectrometry

Sikanen

Franssila

Kauppila

et al. 2009

Mass Spectrom. Rev.

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Microfabrication of analytical devices is currently of growing interest and many microfabricated instruments have also entered the field of mass spectrometry (MS). Various (atmospheric pressure) ion sources as well as mass analyzers have been developed exploiting microfabrication techniques. The most common approach thus far has been the miniaturization of the electrospray ion source and its integration with various separation and sampling units. Other ionization techniques, mainly atmospheric pressure chemical ionization and photoionization, have also been subject to miniaturization, though they have not attracted as much attention. Likewise, all common types of mass analyzers have been realized by microfabrication and, in most cases, successfully applied to MS analysis in conjunction with on-chip ionization. This review summarizes the latest achievements in the field of microfabricated ion sources and mass analyzers. Representative applications are reviewed focusing on the development of fully microfabricated systems where ion sources or analyzers are integrated with microfluidic separation devices or microfabricated pums and detectors, respectively. Also the main microfabrication methods, with their possibilities and constraints, are briefly discussed together with the most commonly used materials.

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“…11 The reasons for the choice of the ion trap as the mass analyzer in our program as well as at Brigham Young University, Oak Ridge National Laboratory, the University of North Carolina, the University of South Florida, and the Defence Evaluation and Research Agency (U.K.) are summarized in Table 2. 5,7,10,12 Two contrasting approaches to building small, capable mass spectrometer systems can be taken. In the "bottom-up" approach, the scale of interest is chosen, and components are built and assembled on that scale.…”

Section: Ion-trap-based Miniature Instrumentsmentioning

confidence: 99%

Handheld Miniature Ion Trap Mass Spectrometers

2009

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For field applications, "miniature" and "rapid" have become almost synonymous, yet these small mass spectrometers are not useful if performance is too severely compromised. (To listen to a podcast about this feature, please go to the Analytical Chemistry website at pubs. acs.org/journal/ancham.)MS is widely regarded as the gold standard for chemical analysis with respect to selectivity, detection limits, and broad applicability. However, mass spectrometers are comparatively delicate instruments, partly a consequence of the need for a vacuum system into which the sample is introduced. There have long been efforts at direct MS analysis of complex mixtures, 1 but extensive sample cleanup and increasingly sophisticated multianalyzers have been involved. These considerations have limited the applications of MS outside the laboratory. It is striking that although progress in many areas of technology is strongly associated with miniaturization, this correlation is barely evident in MS.Nevertheless, for many applications of MS, in situ experiments would have significant advantages over laboratory measurements, even if there are significant losses in analytical performance. Some applications of immediate interest include environmental monitoring (especially surveys that require large numbers of samples), quality control, food safety, forensics, security and public safety, and clinical diagnostics. The objective of this article is to summarize recent progress in developing handheld miniature mass spectrometers. Note that the focus is on complete systems, not particular components, even important ones like the mass analyzer. ON THE SMALL SIDEInterest in small mass analyzers stretches back several decades. For example, a hyperbolic ion trap analyzer the size of a quarter with a 2.5-mm radius and an m/z range of 70,000 was reported in 1991.2 A Mattauch-Herzog-type, nonscanning, double-focusing sector mass analyzer was reported in 1991, and a very small, double-focusing, crossed electric-and magnetic-field sector analyzer was described in 2001.3,4 Recent work by Ramsey, Austin, Short, and others has advanced small analyzers further, and the emphasis is increasingly turning to microelectromechanical systems (MEMS)-fabricated mass analyzers. [5][6][7][8] However, only in the past decadesand especially in the past 5 yearsshas significant progress been made in the development of small, low-power, portable, autonomous mass spectrometer systems; some have progressed to the point of commercialization. A review in 2000 summarized the mass analyzers used in miniature instruments, showing examples of virtually all the common types, including quadrupole mass filters, quadrupole ion traps, magnetic sector fields, TOF, and FT ion cyclotron resonance instruments. 9 More recent work has seen the commercialization of a novel toroidal ion trap system. 10 A website devoted to small instruments and a conference series on MS in harsh environments prominently features handheld mass spectrometers (www.gcms.

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Fabrication and testing of a miniature cylindrical ion trap mass spectrometer constructed from low temperature co-fired ceramics

Cited by 68 publications

References 23 publications

Optimization and simulation of MEMS rectilinear ion trap

Optimization and simulation of MEMS rectilinear ion trap

Microchip technology in mass spectrometry

Handheld Miniature Ion Trap Mass Spectrometers

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