Fabrication and photophysical properties of singlet oxygen generating nanoporous membrane

Wang, Kang Kyun; Jung, Mooyoung; Choi, Kyu-Hong; Shin, Hee Won; Oh, Seung Im; Im, Ji Eun; Kim, Da Hee; Kim, Yong Rok

doi:10.1016/j.surfcoat.2010.08.061

Cited by 8 publications

(11 citation statements)

References 22 publications

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“…The difference in the peak width and position is possibly due to the self-coupling of Hp molecules bonded to the surface and the inhomogeneous bonding nature of Hp molecules on the surface of Co-Cr alloy plate. The fluorescence spectrum of Hp ( ex = 510 nm) solution in Figure 3 ground states [29][30][31]. Therefore, the results suggest that Hp molecules are bonded to the surface of Co-Cr alloy through the esterification reaction without a significant change of its photophysical properties.…”

Section: Resultsmentioning

confidence: 85%

Photofunctional Co-Cr Alloy Generating Reactive Oxygen Species for Photodynamic Applications

Wang

Kim

Lee

et al. 2013

International Journal of Photoenergy

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We report the fabrication of photofunctional Co-Cr alloy plate that is prepared by a simple modification process for photodynamic application. Photoinduced functionality is provided by the photosensitizer of hematoporphyrin (Hp) that initially generates reactive oxygen species (ROS) such as superoxide anion radical and singlet oxygen. The photosensitizer with carboxyl group was chemically bonded to the surface of the Co-Cr alloy plate by esterification reaction. Microstructure and elemental composition of the Co-Cr alloy plate were checked with scanning electron microscopy (SEM) and energy dispersive X-ray spectrometer (EDS). Fabrication of the photofunctionality of the Co-Cr alloy plate was confirmed with X-ray photoelectron spectroscopy (XPS), reflectance UV-Vis absorption, and emission spectroscopy. Reactive oxygen generation from the photofunctional Co-Cr alloy plate was confirmed by using the decomposition reaction of 1,3-diphenylisobenzofuran (DPBF). The results suggest that the immobilized photosensitizer molecules on the surface of Co-Cr alloy plate still possess their optical and functional properties including reactive oxygen generation. To open the possibility for its application as a photodynamic material to biological system, the fabricated photofunctional Co-Cr alloy is applied to the decomposition of smooth muscle cells.

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Section: Resultsmentioning

confidence: 85%

Photofunctional Co-Cr Alloy Generating Reactive Oxygen Species for Photodynamic Applications

Wang

Kim

Lee

et al. 2013

International Journal of Photoenergy

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“…On the other hand, the -CH 3 (2973 cm −1 ) vibration peak disappears significantly in its intensity. It is due to the removal step of the methyl group (−CH 3 ) of APTES during the attachment reaction process of APTES and NAM [11,16,17]. The increased peak intensity of the −OH (3650 ∼3200 cm −1 ) stretching vibration in Figure 2(a) implies that the hydroxyl group of the NAM surface is enhanced throughout the surface modification process.…”

Section: Resultsmentioning

confidence: 98%

“…All solvents were purchased from Aldrich and used without further purification. For the surface modification of NAM, NAM was immersed into the APTES ((aminopropyl)triethoxysilane, 0.1 M)/CHCl 3 solution at room temperature for 1 h [8][9][10][11]. After washing and drying, the surface-modified NAM was immersed in PtCP (10 −5 M)/toluene at 50 • C for 24 h and then washed with pure toluene and distilled water.…”

Section: Methodsmentioning

confidence: 99%

“…The nanoporous alumina membranes were fabricated by two-step aluminum anodic oxidation process [7]. The inner and the outer surfaces of the fabricated NAMs were modified with organo-silane agent [8][9][10][11]. The photosensitizer (PtCP: [5,10,15-triphenyl-20-(4-methoxycarbonylphenyl)-porphyrin] platinum) was covalently bonded to the amine-terminated NAM surface by a nucleophilic acyl substitution reaction [12].…”

Section: Introductionmentioning

confidence: 99%

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Fabrication of Photofunctional Nanoporous Membrane and Its Photoinactivation Effect of Vesicular Stomatitis Virus

Wang

Kim

et al. 2011

Journal of Nanomaterials

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Fabrication and photophysical study of photofunctional nanoporous alumina membrane (PNAM) were performed, and its application of photodynamic antimicrobial chemotherapy (PACT) was investigated. Nanoporous alumina membrane (NAM) was fabricated by two-step aluminium anodic oxidation process. Surface of the fabricated NAM was modified with organo-silane agent to induce covalent bonding between NAM and a photosensitizer (PtCP: [5,10,15-triphenyl-20-(4-methoxycarbonylphenyl)-porphyrin] platinum). PtCP was covalently bonded to the surface of the modified NAM by nucleophilic acyl substitution reaction process. The morphology and the photophysical properties of the fabricated PNAM were confirmed with field emission scanning electron microscope (FE-SEM), steady-state spectroscopies, and nanosecond laser-induced time-resolved spectroscopy. For the efficacy study of PNAM in PACT, an enveloped animal virus, vesicular stomatitis virus (VSV), was utilized as a target organism. Antiviral effect of the PNAM-PACT was measured by the extent of suppression of plaque-forming units (PFU) after the light irradiation. In the cultures inoculated with PACT-treated VSV, the suppression of PFU was prominent, which demonstrates that PNAM is a potential bio clean-up tool.

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“…PpIX is covalently bonded to the amine-terminated APTES surface by a nucleophilic acyl substitution reaction. Molecular modification of PpIX was done through the chemical amide bond between protonated and activated COOH groups of PpIX dichloride and NH 2 groups of APTES which resulted in coating PpIX with a layer of APTES or modified PpIX (MPpIX) [19,29]. The modification is expected to improve the solubility and stability of PpIX in the aqueous solutions.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of protoporphyrin IX performance in aqueous solutions for photodynamic therapy

Homayoni

Jiang

Zou

et al. 2015

Photodiagnosis and Photodynamic Therapy

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Molecular modification of protoporphyrin IX (PpIX) was conducted to improve its water solubility and therapeutic performance for photodynamic therapy. The carboxylic acid and the two nitrogen atoms in the core of PpIX molecule were protonated following by conjugation with 3-aminopropyl triethoxysilane (APTES). Then, folic acid (FA) was conjugated to the APTES-coated PpIX (MPpIX) through chemical bonding between FA and protonated PpIX. The results showed that APTES coating can stabilize PpIX and increase its water solubility. Consequently, this leads to the enhancement in luminescence and singlet oxygen production. Upon X-ray irradiation, singlet oxygen can be detected in the MPpIX but not in PpIX. This means that MPpIX can be used for deep cancer treatment as X-ray can penetrate deeply into tissue. Molecular modification also reduces the dark toxicity of PPIX and increases their cell uptake. All these traits indicate that the Molecular modification of PpIX may potentially improve the efficacy of photodynamic therapy for cancer treatment.

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Fabrication and photophysical properties of singlet oxygen generating nanoporous membrane

Cited by 8 publications

References 22 publications

Photofunctional Co-Cr Alloy Generating Reactive Oxygen Species for Photodynamic Applications

Photofunctional Co-Cr Alloy Generating Reactive Oxygen Species for Photodynamic Applications

Fabrication of Photofunctional Nanoporous Membrane and Its Photoinactivation Effect of Vesicular Stomatitis Virus

Enhancement of protoporphyrin IX performance in aqueous solutions for photodynamic therapy

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