“…[21][22][23] Recent research on prosthetic valves focused on applying modifications to PU, 10,24 and different research groups reported in vitro and in vivo tests with valves made of polycarbonate urethane (PCU), 20,25 composites thereof, [26][27][28][29] and siloxane-based PUs. 30,31 In 2021, Foldax used the LifePolymer™, a siloxane poly(urethane-urea) (SiPUU), to develop the Tria valve, the first polymeric valve implanted in patients. 24 However, long-term prosthesis performance has not been demonstrated yet.…”