Fabrication and in vitro biocompatibility of sodium tripolyphosphate-crosslinked chitosan–hydroxyapatite scaffolds for bone regeneration

Preparation and Characterization of TPP-Chitosan Crosslinked Scaffolds for Tissue Engineering

“…CS mechanical properties were improved by CS crosslinking with TPP. In particular, the increase in CM values was directly related to the TPP concentration (greater cross-linking degree), such finding in agreement with literature data [ 35 , 38 ]. A higher cross-linking time also positively affected the scaffold mechanical properties, confirming the importance of this parameter on the scaffold performances.…”

“…Indeed, the improved mechanical behaviour of the CS2_TPP samples was presumably due to not only a greater crosslinking but also a less porosity (P L %). In conclusion, the better CM values were obtained for the samples CS1_TPP2 8h , CS2_TPP2 2h and CS2_TPP2 8h , which showed a modulus approaching the typical value of trabecular bone (ranging between 2 and 3000 MPa) [35,38].…”

Hydroxyapatite Consolidated by Zirconia: Applications for Dental Implant

“…In addition, HAp is very well-known biocompatible substitution for the essential mineral constituents of skeletal bones that can be utilized as orthopedic surgeries and tooth implant [20,21]. HAp is considered to be extremely bioactive, osteoconductive, biocompatible, non-toxic, non-immunogenic, and non-inflammatory [22,23]. The measurement of alkaline phosphatase activity has indicated that naturally isolated HAp can to be utilized for progression of both cell proliferation and differentiation [17].…”

La-Doped mesoporous calcium silicate/chitosan scaffolds for bone tissue engineering

“…[33][34][35] In previous work, it was found that both CS and CTS possessed prominent biocompatibility and latent capacity for biomedical applications. [36][37][38] Interestingly, both the structure and chemical composition of the La-MSC/ CTS scaffolds provided a basis for rapid cell adhesion and proliferation. Furthermore, a peak of cell adhesion and proliferation occurred in the Ca3La1/CTS group.…”