Fabrication and finite element simulation of 3D printed poly L-lactic acid scaffolds coated with alginate/carbon nanotubes for bone engineering applications

Moarrefzadeh, Aeiin; Morovvati, M.R.; Angili, Sajad Niazi; Smaisim, Ghassan Fadhil; Khandan, Amir Salar; Toghraie, Davood

doi:10.1016/j.ijbiomac.2022.10.238

Cited by 28 publications

(8 citation statements)

References 48 publications

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“…1 To overcome these limitations, nanoparticles are added to PLA to improve its properties [30][31][32][33][34][35] one of these nanoparticles is graphene, which was discovered in 2004 and has unique properties. 36 Improves mechanical properties such as tensile strength and acts as an impermeable agent for oxygen transfer even at high temperatures. 37 Thus, the addition of graphene as a reinforcement agent improves the thermal, physical and mechanical properties of the polymer matrix.…”

Section: Introductionmentioning

confidence: 99%

A review: studying the effect of graphene nanoparticles on mechanical, physical and thermal properties of polylactic acid polymer

2023

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Section: Introductionmentioning

confidence: 99%

A review: studying the effect of graphene nanoparticles on mechanical, physical and thermal properties of polylactic acid polymer

2023

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“…This method is based on detection and colorimetry that pathogens with the naked eye are identified using latex particles or gold nanoparticles as contrast agents. The detection also depends on the pathogenic species (Li et al, 2022;Cai et al, 2022;Moarrefzadeh et al, 2022;Liu et al, 2022;Hai et al, 2022;Smaisim et al, 2022a). This method is predicated on detection and calorimetry within which pathogens are identified with the optic using latex particles or gold nanoparticles as contrast agents.…”

Section: Lateral Flow Immunochromatographic Testsmentioning

confidence: 99%

Application of nano-antibiotics in the diagnosis and treatment of infectious diseases

Al-Awsi¹,

Alameri

Al-Dhalimy

et al. 2024

Braz. J. Biol.

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Infectious diseases are the leading cause of death worldwide. Thus, nanotechnology provides an excellent opportunity to treat drug-resistant microbial infections. Numerous antibiotics have been used to inhibit the growth and kill of microbes, but the development of resistance and the emergence of side effects have severely limited the use of these agents. Due to the development of the nanotechnology, nanoparticles are widely used as antimicrobials. Silver and chitosan nanoparticles have antifungal, antiviral and antibacterial properties, and many studies confirm the antifungal properties of silver nanoparticles. Nowadays, the use of nanoparticles in the diagnosis and treatment of infectious diseases has developed due to less side effects and also the help of these particles in effective drug delivery to the target tissue. Liposomes are also used as carriers of drug delivery, genes, and modeling of cell membranes in both animals and humans. The ability of these liposomes to encapsulate large amounts of drugs, minimize unwanted side effects, high effectiveness and low toxicity has attracted the interest of researchers. This review article examines recent efforts by researchers to identify and treat infectious diseases using antimicrobial nanoparticles and drug nano-carriers.

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“…Natural polyphenols are commonly used as ligands to couple metal ions, avoid biotoxicity caused by the massive enrichment of metal ions, and regulate human immunity. 140,141 However, the clinical application of "immunomodulatory" scaffolds requires an indepth study of the biological responses activated by the scaffolds. In addition, its application potential must be tested in large animal models and clinical trials.…”

Section: Immunomodulatory Designmentioning

confidence: 99%

“…For example, natural polyphenolic extracts can be used for this purpose. Natural polyphenols are commonly used as ligands to couple metal ions, avoid biotoxicity caused by the massive enrichment of metal ions, and regulate human immunity 140,141 . However, the clinical application of “immunomodulatory” scaffolds requires an in‐depth study of the biological responses activated by the scaffolds.…”

Section: Improved Strategies For Fabricating Tissue Engineering Scaff...mentioning

confidence: 99%

Research progress in degradable metal‐based multifunctional scaffolds for bone tissue engineering

He,

Li,

et al. 2023

MedComm – Biomaterials and Applications

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The increasing prevalence of orthopedic‐related diseases necessitates the development of effective orthopedic implants. Conventional metal scaffolds used in orthopedic devices have limitations such as poor biocompatibility and the need for a second surgery to remove the scaffold. Degradable metal‐based scaffolds, including metal‐based scaffolds and multifunctional scaffolds doped with metal elements, are a rapidly developing tissue engineering strategy aimed at utilizing the mechanical and biological properties of metal elements to create a support structure that matches the complex bone regeneration environment. Repairing bone defects involves the regeneration of various tissues, and incomplete repair can negatively affect bone function and overall recovery. Therefore, combining metal‐based degradable materials with other active components has great potential for enhancing the versatility and clinical applications of scaffolds. Multifunctional scaffolds doped with metal elements have better biocompatibility, osteoinductivity, biodegradability, matching mechanical, and microenvironmental adjustment capabilities. Moreover, these metal‐doped scaffolds possess the advantages of controlled release of metal ions, multifunctionality, and faster degradation. This review focuses on the materials and techniques used for constructing degradable metal‐based scaffolds. Furthermore, this study discussed the potential for designing and constructing multifunctional biodegradable metal‐based scaffolds doped with metal elements by integrating multiple strategies.

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Fabrication and finite element simulation of 3D printed poly L-lactic acid scaffolds coated with alginate/carbon nanotubes for bone engineering applications

Cited by 28 publications

References 48 publications

A review: studying the effect of graphene nanoparticles on mechanical, physical and thermal properties of polylactic acid polymer

A review: studying the effect of graphene nanoparticles on mechanical, physical and thermal properties of polylactic acid polymer

Application of nano-antibiotics in the diagnosis and treatment of infectious diseases

Research progress in degradable metal‐based multifunctional scaffolds for bone tissue engineering

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