Fabrication and evaluation of poly (vinyl alcohol)/gelatin fibrous scaffold containing ZnO nanoparticles for skin tissue engineering applications

Nasiri, Golara; Azarpira, Negar; Alizadeh, Ali; Aminshahidi, Maneli; Alavi, Omid; Kamali, Majid; Zebarjad, Seyed Mojtaba

doi:10.1016/j.mtcomm.2022.104476

Cited by 7 publications

(4 citation statements)

References 62 publications

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“…The water absorption ability of sponges is affected by the hydrophilicity of their constituent materials 64 . As the hydrophilic substances, gelatin and HNTs have good water absorption performance due to abundant hydrophilic groups 65–67 . Furthermore, gelatin and HNTs can form strong interactions with PVA through hydrogen bonds 68–70 .…”

Section: Resultsmentioning

confidence: 99%

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Fabricating of poly(vinyl alcohol)/halloysite nanotubes/gelatin composite sponges with enhanced mechanical properties and rapid water absorption speed

Wu,

Chen,

Feng

et al. 2023

Polymer Engineering & Sci

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In the biomedical field, polyvinyl alcohol (PVA) sponge has been widely used. In particular, it is considered a potential implant material for repairing soft tissues. However, its insufficient water absorption and mechanical properties limit its application. In this work, a novel PVA/halloysite nanotubes (HNTs)/gelatin ternary composite sponge was prepared by water solution mixing and casting techniques. HNTs and gelatin/PVA solution were mixed at different weight ratios. The structure of the ternary composite sponges was characterized by using scanning electron microscopy. The physical properties of the ternary composite sponges were characterized. The maximum water absorption reached 1783.5% with a rapid water absorption speed at a weight ratio of HNTs/gelatin of 1:8. Owing to its interconnected macroporous structure and good interfacial interaction, its highest compression strength and tensile strength reached 8.22, 1.51 MPa, respectively. In addition, its thermal stability was enhanced as well, which demonstrated that the prepared composite sponge had better performance than the pure PVA sponge by constructing a ternary system. Therefore, the results suggest that the PVA/HNTs/gelatin ternary composite sponge shows a wider application value as a potential material for repairing soft tissue.Highlights A composite PVA sponge with promising applications in tissue engineering. Simple preparation method, water solution mixing and casting techniques. Pioneering a PVA/HNTs/gelatin ternary system sponge. Improved water absorption ability and mechanical properties.

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Section: Resultsmentioning

confidence: 99%

“…64 As the hydrophilic substances, gelatin and HNTs have good water absorption performance due to abundant hydrophilic groups. [65][66][67] Furthermore, gelatin and HNTs can form strong interactions with PVA through hydrogen bonds. [68][69][70] Therefore, the water absorption of the composite sponge was further increased.…”

Section: Water Absorption Abilitymentioning

confidence: 99%

Fabricating of poly(vinyl alcohol)/halloysite nanotubes/gelatin composite sponges with enhanced mechanical properties and rapid water absorption speed

Wu,

Chen,

Feng

et al. 2023

Polymer Engineering & Sci

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“…In here, ZnO NPs could disrupt bacterial membrane via electrostatic interactions with the cell wall as well as production of ROSs, and also exhibiting photocatalytic activity that led to producing ROSs and disturbing vital compounds of bacteria. 165 3.2.2. Poly(lactic acid)-based BNCs.…”

Section: Mater Advmentioning

confidence: 99%

Innovative approaches in skin therapy: bionanocomposites for skin tissue repair and regeneration

Bal-Öztürk,

Alarçin,

Yaşayan

et al. 2024

Mater. Adv.

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“…These features contribute to the potential clinical utility of ZnONPs. Reports also indicate that gelatin-bound ZnO nanoparticles are biodegradable, biocompatible, cost-effective, highly permeable, and have antimicrobial properties [28,29].…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis of Gelatin-coated Zinc oxide nanocomposite from Coccinia indica extract and its antibacterial, antioxidant, anticancer and wound-healing properties

Senthikumar,

Rajkumar,

Vimala

et al. 2024

Preprint

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This present study deals with the synthesis of gelatin-loaded zinc oxide nanocomposites (GN/ZnONCs) using Coccinia indica seed extract using the green preparative method. Synthesized GN/ZnONCs were confirmed by using various characterization techniques for chemical and physical properties. The results of the UV-Vis spectral absorption peak showed 182 nm, and the FTIR study has confirmed the presence of various functional groups. The XRD study illustrated the crystalline structure of GN/ZnONCs. The DLS measurement indicated a stable size of 189.18 nm, with a zeta potential value demonstrating high stability at −30 mV. SEM images displayed the morphology of cauliflower-like spherical shapes and revealed their average particle size, respectively. The 100 µg/mL concentration of GN/ZnONCs exhibited higher antibacterial efficiencies against gram-positive and gram-negative bacteria. Subsequently, the GN/ZnONCs also exhibited excellent antioxidant properties in the DPPH assay (92.61 ± 2.45%), the ABTS assay (76.35 ± 1.54%), and the hydroxyl scavenging assay (88.42 ± 1.73%) at 100 μg/ml concentration. In addition, GN/ZnONCs treatment on the cancer cell line HT-29 showed good anticancer activity with an IC50 value of 45.4 μg/mL. Furthermore, wound healing experiments with enriched GN/ZnONCs with the highest contraction of 98.37 ± 1.45 confirmed faster wound healing and a greater role in the formation of new tissues and cells. The study indicates that green synthesized GN/ZnONCs had anti-bacterial, anti-cancer, and wound healing properties that were also eco-friendly and cost-effective, and the possible mechanisms were illustrated for biomedical applications.

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Fabrication and evaluation of poly (vinyl alcohol)/gelatin fibrous scaffold containing ZnO nanoparticles for skin tissue engineering applications

Cited by 7 publications

References 62 publications

Fabricating of poly(vinyl alcohol)/halloysite nanotubes/gelatin composite sponges with enhanced mechanical properties and rapid water absorption speed

Fabricating of poly(vinyl alcohol)/halloysite nanotubes/gelatin composite sponges with enhanced mechanical properties and rapid water absorption speed

Innovative approaches in skin therapy: bionanocomposites for skin tissue repair and regeneration

Biosynthesis of Gelatin-coated Zinc oxide nanocomposite from Coccinia indica extract and its antibacterial, antioxidant, anticancer and wound-healing properties

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