Fabrication and evaluation of artemether loaded polymeric nanorods obtained by mechanical stretching of nanospheres

Bhide, Atharva R; Jindal, Anil

doi:10.1016/j.ijpharm.2021.120820

Cited by 8 publications

(6 citation statements)

References 44 publications

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“…Bhide and Jindal have fabricated artemether-loaded PLGA nanorods in order to evaluate the effect of shape and aspect ratio on nanocarriers. 101 They embedded artemether-loaded PLGA nanospheres in a PVA/glycerol film and stretched the film to different extents in order to form different shapes. The in vitro release profile showed that particles stretched into nanorods showed a significantly slower release until the 24-h time mark than both the free drug and nanospheres (mitigating the burst release seen with the free drug and nanospheres alone), however, in vivo studies have yet to be reported.…”

Section: Infectious Diseases Treatmentsmentioning

confidence: 99%

Injectable controlled‐release systems for the prevention and treatment of infectious diseases

Kunkel,

McHugh

2023

J Biomedical Materials Res

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Pharmaceutical drugs, including vaccines, pre‐ and post‐exposure prophylactics, and chronic drug therapies, are crucial tools in the prevention and treatment of infectious diseases. These drugs have the ability to increase survival and improve patient quality of life; however, infectious diseases still accounted for more than 10.2 million deaths in 2019 before the COVID‐19 pandemic. High mortality can be, in part, attributed to challenges in the availability of adequate drugs and vaccines, limited accessibility, poor drug bioavailability, the high cost of some treatments, and low patient adherence. A majority of these factors are logistical rather than technical challenges, providing an opportunity for existing drugs and vaccines to be improved through formulation. Injectable controlled‐release drug delivery systems are one class of formulations that have the potential to overcome many of these limitations by releasing their contents in a sustained manner to reduce the need for frequent re‐administration and improve clinical outcomes. This review provides an overview of injectable controlled drug delivery platforms, including microparticles, nanoparticles, and injectable gels, detailing recent developments using these systems for single‐injection vaccination, long‐acting prophylaxis, and sustained‐release treatments for infectious disease.

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Section: Infectious Diseases Treatmentsmentioning

confidence: 99%

Injectable controlled‐release systems for the prevention and treatment of infectious diseases

Kunkel,

McHugh

2023

J Biomedical Materials Res

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“…Nanorods showed biocompatibility with THP-1 monocytes and rat erythrocytes. Hence, nanorods were found to be suitable for intravenous delivery of artemether . Hence, the objective of the present study was the evaluation of pharmacokinetics, biodistribution, and antimalarial efficacy of artemether loaded in polymeric nanorods.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Pharmacokinetics, Biodistribution, and Antimalarial Efficacy of Artemether-Loaded Polymeric Nanorods

et al. 2022

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Artemether oily injection is recommended for the treatment of severe malaria by the intramuscular route. The major limitations of the artemisinin combination therapy are erratic absorption from the injection site and high dosing frequency due to a very short elimination half-life of the drug. Advanced drug delivery systems have shown significant improvement in the current malaria therapy; the desired drug concentration within infected erythrocytes is yet the major challenge. Recently, we have reported the fabrication of artemether-loaded polymeric nanorods for intravenous malaria therapy which was found to be biocompatible with THP-1 monocytes and rat erythrocytes. The objective of the present study was the evaluation of pharmacokinetics, biodistribution, and antimalarial efficacy of artemether-loaded polymeric nanorods. Scanning electron microscopy and confocal microscopy studies revealed that both nanospheres and nanorods were adsorbed onto the surface of rat erythrocytes after an incubation of 10 min. After intravenous administration to rats, artemether nanorods showed higher plasma concentration and lower elimination rate of artemether when compared with nanospheres. The biodistribution studies showed that, at 30 min, the liver concentration of DiRloaded nanospheres was higher than that of DiR-loaded nanorods after intravenous administration to BALB/c mice. The in vitro schizont inhibition study showed that both nanorods and nanospheres exhibited concentration-dependent parasitic inhibition, wherein at lower concentrations (2 ppm), nanorods were more effective than nanospheres. However, at higher concentrations, nanospheres were found to be more effective. Nanorods showed higher chemosuppression on day 5 and day 7 than nanospheres and free artemether when studied with the Plasmodium berghei mouse model. Moreover, the survival rate of P. berghei infected mice was also found to be higher after treatment with artemether nanoformulations when compared with free artemether. In conclusion, polymeric nanorods could be a promising next-generation delivery system for the treatment of malaria.

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“…The interest in non-spherical particles, such as ellipsoids, spans over various disciplines, including geology [1], physics [2], material sciences [3] and pharmaceutics [4,5]. In life sciences, some fundamental observations on the effects of particle shape on phagocytosis [6] and the interaction with model endothelial substrates under shear flow [7] motivated excessive studies on shape-dependency of biodistribution [8,9], drug delivery [10], and ecotoxicity [11].…”

Section: Introductionmentioning

confidence: 99%

Predictive Shapes of Ellipsoid PPDL-PTHF Copolymer Particles Prepared by the Phantom Stretching Technique

Wischke

Hofmann

2022

Polymers

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Ellipsoidal polymer particles can be prepared from spheres by unidirectional stretching at elevated temperatures, while the particles’ aspect ratios (AR) that result from this phantom stretching methodology are often not precisely predictable. Here, an elastic deformation model was exemplarily evaluated for ~50 µm spherical microparticles from PPDL-PTHF block copolymers. The prolate ellipsoidal particles, obtained by stretching in polyvinyl alcohol phantoms, differed in dimensions at identical relative phantoms elongations up to 150%, depending on the relative polymer composition and their systematically altered mechanical properties. Importantly, the resulting particle shapes within the studied range of AR up to ~4 matched the predictions of the elastic deformation model, which includes information of the elastic moduli of phantom and particle materials. These data suggest that the model may be applicable to predict the conditions needed to precisely prepare ellipsoids of desired AR and may be applicable to various deformable particle materials.

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Fabrication and evaluation of artemether loaded polymeric nanorods obtained by mechanical stretching of nanospheres

Cited by 8 publications

References 44 publications

Injectable controlled‐release systems for the prevention and treatment of infectious diseases

Injectable controlled‐release systems for the prevention and treatment of infectious diseases

Evaluation of Pharmacokinetics, Biodistribution, and Antimalarial Efficacy of Artemether-Loaded Polymeric Nanorods

Predictive Shapes of Ellipsoid PPDL-PTHF Copolymer Particles Prepared by the Phantom Stretching Technique

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