Fabrication and characterization of zein nanoparticles by dextran sulfate coating as vehicles for delivery of curcumin

Yuan, Yongkai; Li, Hao; Zhu, Junxiang; Liu, Chengzhen; Sun, Xun; Wang, Dongfeng; Xu, Ying

doi:10.1016/j.ijbiomac.2019.10.149

Cited by 87 publications

(27 citation statements)

References 45 publications

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“…Interestingly, as the ratio increased above 15:1, no obvious precipitation was observed, and turbidity gradually plateaued even at a high acceleration of 10 000× g . A similar result was also reported by Yuan et al ., 45 who found that zein combined with dextran sulfate could provide excellent resistance to gravitational separation.…”

Section: Resultssupporting

confidence: 88%

Fabrication and characterization of Pickering emulsion gels stabilized by zein/pullulan complex colloidal particles

Liu

Shan

et al. 2020

J Sci Food Agric

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BACKGROUND Zein particles are unsuitable as stabilizers of Pickering emulsions because of their high hydrophobicity. However, few studies have reported on the use of a strong hydrophilic neutral polysaccharide to regulate its wettability. In this work, zein/pullulan complex particles (ZPPs) were formulated by an anti‐solvent method to fabricate Pickering emulsions. RESULTS The presence of pullulan increased the size, decreased the zeta, and provided excellent resistance to the gravitational separation of zein. Scanning electron microscopy (SEM) revealed that the shape of zein particles changed from spherical as they became aggregated ZPP nanoparticles. Fourier transform infrared (FTIR) spectroscopy indicated that the flocculation phenomenon of ZPPs was related to the hydrogen bond between zein and pullulan. Moreover, the hydrophobicity of zein was modified by hydrophilic pullulan to endow the ZPPs with nearly neutral wettability when the mass ratio was 15:1, allowing for the preparation of stable Pickering emulsions. In contrast to zein, the ZPPs contributed to building a compact interface layer around the droplets and smaller emulsion droplets. Under a certain ZPP concentration, the size and viscosity of emulsion increased with an increase in the oil volume fraction, indicating that the Pickering emulsions stabilized by ZPPs showed better stability against coalescence. Confocal laser scanning microscopy (CLSM) revealed that the ZPPs constructed a dense filling layer on the surface of oil droplets, thus further emphasizing that ZPPs can potentially be used in fabricating Pickering emulsion gels. CONCLUSION Zein/pullulan complex particles are an excellent Pickering emulsion gel stabilizer that can be used in the delivery system of bioactive substances in food formulations. © 2020 Society of Chemical Industry

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Section: Resultssupporting

confidence: 88%

Fabrication and characterization of Pickering emulsion gels stabilized by zein/pullulan complex colloidal particles

Liu

Shan

et al. 2020

J Sci Food Agric

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“…The authors concluded that curcumin loaded into the fabricated zein nanoparticles exhibited increased storage stability and bioaccessibility. Zein fibers loaded with curcumin have been prepared by the electrospinning technique as well [ 197 ]. The obtained curcumin-loaded fibers exhibited antibacterial activity against S. aureus and E. coli and the authors suggested that they could find use in active food packaging applications.…”

Section: Organic-based Delivery Systemsmentioning

confidence: 99%

Innovative Delivery Systems Loaded with Plant Bioactive Ingredients: Formulation Approaches and Applications

Kyriakoudi

Spanidi²,

Mourtzinos

et al. 2021

Plants

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Plants constitute a rich source of diverse classes of valuable phytochemicals (e.g., phenolic acids, flavonoids, carotenoids, alkaloids) with proven biological activity (e.g., antioxidant, anti-inflammatory, antimicrobial, etc.). However, factors such as low stability, poor solubility and bioavailability limit their food, cosmetics and pharmaceutical applications. In this regard, a wide range of delivery systems have been developed to increase the stability of plant-derived bioactive compounds upon processing, storage or under gastrointestinal digestion conditions, to enhance their solubility, to mask undesirable flavors as well as to efficiently deliver them to the target tissues where they can exert their biological activity and promote human health. In the present review, the latest advances regarding the design of innovative delivery systems for pure plant bioactive compounds, extracts or essential oils, in order to overcome the above-mentioned challenges, are presented. Moreover, a broad spectrum of applications along with future trends are critically discussed.

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“…There were multiple studies carried out by using zein in combination with various reagents. Some of them concerned the use of zein with gelatin, alginate, and/or hyaluronan combinations [ 96 ], resulting in high stability and successful drug encapsulation. Whereas, zein NPs covered with quercetaget and hyaluronic acid resulted in high stability, decreased thermal degradation, and slow curcumin release [ 91 , 95 ].…”

Section: Curcumin-loaded Colloidal Delivery Systemsmentioning

confidence: 99%

Properties, Extraction Methods, and Delivery Systems for Curcumin as a Natural Source of Beneficial Health Effects

et al. 2020

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This review discusses the impact of curcumin—an aromatic phytoextract from the turmeric (Curcuma longa) rhizome—as an effective therapeutic agent. Despite all of the beneficial health properties ensured by curcumin application, its pharmacological efficacy is compromised in vivo due to poor aqueous solubility, high metabolism, and rapid excretion that may result in poor systemic bioavailability. To overcome these problems, novel nanosystems have been proposed to enhance its bioavailability and bioactivity by reducing the particle size, the modification of surfaces, and the encapsulation efficiency of curcumin with different nanocarriers. The solutions based on nanotechnology can improve the perspective for medical patients with serious illnesses. In this review, we discuss commonly used curcumin-loaded bio-based nanoparticles that should be implemented for overcoming the innate constraints of this natural ingredient. Furthermore, the associated challenges regarding the potential applications in combination therapies are discussed as well.

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Fabrication and characterization of zein nanoparticles by dextran sulfate coating as vehicles for delivery of curcumin

Cited by 87 publications

References 45 publications

Fabrication and characterization of Pickering emulsion gels stabilized by zein/pullulan complex colloidal particles

Fabrication and characterization of Pickering emulsion gels stabilized by zein/pullulan complex colloidal particles

Innovative Delivery Systems Loaded with Plant Bioactive Ingredients: Formulation Approaches and Applications

Properties, Extraction Methods, and Delivery Systems for Curcumin as a Natural Source of Beneficial Health Effects

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