Fabrication and characterization of the flexible neural microprobes with improved structural design

Fomani, Arash A.; Mansour, Raafat R.

doi:10.1016/j.sna.2011.04.024

Cited by 43 publications

(27 citation statements)

References 52 publications

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“…Metal microneedles have been prepared by three-dimensional laser ablation [49, 62], laser cutting [63], wet etching [48, 64], and metal electroplating methods [65–66]. Rows of solid metal microneedles were fabricated directly, whereas two-dimensional arrays of microneedles have been made by cutting microneedles into stainless steel and titanium metal sheets and then bending them at a angle out of the plane of the sheet.…”

Section: Fabrication Of Microneedlesmentioning

confidence: 99%

“…Rows of solid metal microneedles were fabricated directly, whereas two-dimensional arrays of microneedles have been made by cutting microneedles into stainless steel and titanium metal sheets and then bending them at a angle out of the plane of the sheet. Two-dimensional metal microneedles have also been prepared by electroplating or electroless-plating of metal onto positive or negative microneedle molds [65]. …”

Section: Fabrication Of Microneedlesmentioning

confidence: 99%

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Microneedles for drug and vaccine delivery

Kim

Park

Prausnitz

2012

Advanced Drug Delivery Reviews

1,375

1,036

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Microneedles were first conceptualized for drug delivery many decades ago, but only became the subject of significant research starting in the mid-1990’s when microfabrication technology enabled their manufacture as (i) solid microneedles for skin pretreatment to increase skin permeability, (ii) microneedles coated with drug that dissolves off in the skin, (iii) polymer microneedles that encapsulate drug and fully dissolve in the skin and (iv) hollow microneedles for drug infusion into the skin. As shown in more than 350 papers now published in the field, microneedles have been used to deliver a broad range of different low molecular weight drugs, biotherapeutics and vaccines, including published human studies with a number of small-molecule and protein drugs and vaccines. Influenza vaccination using a hollow microneedle is in widespread clinical use and a number of solid microneedle products are sold for cosmetic purposes. In addition to applications in the skin, microneedles have also been adapted for delivery of bioactives into the eye and into cells. Successful application of microneedles depends on device function that facilitates microneedle insertion and possible infusion into skin, skin recovery after microneedle removal, and drug stability during manufacturing, storage and delivery, and on patient outcomes, including lack of pain, skin irritation and skin infection, in addition to drug efficacy and safety. Building off a strong technology base and multiple demonstrations of successful drug delivery, microneedles are poised to advance further into clinical practice to enable better pharmaceutical therapies, vaccination and other applications.

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Section: Fabrication Of Microneedlesmentioning

confidence: 99%

Section: Fabrication Of Microneedlesmentioning

confidence: 99%

Microneedles for drug and vaccine delivery

Kim

Park

Prausnitz

2012

Advanced Drug Delivery Reviews

1,375

1,036

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“…MNs have been made primarily by using the technologies of the microelectronics industry to produce arrays on a silicon wafer, 14,15 metal [16][17][18] and polymer MNs. [19][20][21] Solid MNs have been shown to increase skin permeability by up to four orders of magnitude for compounds ranging in size from small molecules, proteins to nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

A solid polymer microneedle patch pretreatment enhances the permeation of drug molecules into the skin

et al. 2017

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“…Spinal cord and traumatic brain injuries (TBI) are sustained by millions of people each year, with almost half a million emergency department visits for TBI made annually by children 1. Research efforts toward neural tissue engineering are in the early stages of discovery, with investigations of regeneration of central nervous system (CNS) tissues,2, 3 soft biomaterials to decrease inflammation from implantable devices,4–7 and non‐invasive drug delivery to the CNS 6, 8–10. Previous efforts to develop biomaterials for neural tissue repair have focused on anti‐inflammatory coatings for implantable devices10–13 or construction of nerve guide conduits for peripheral and central nerve repair 14–22.…”

Section: Introductionmentioning

confidence: 99%

Silk Hydrogels as Soft Substrates for Neural Tissue Engineering

Hopkins

Laporte

Tortelli

et al. 2013

Adv Funct Materials

165

156

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There is great need for soft biomaterials that match the stiffness of human tissues for tissue engineering and regeneration. Hydrogels are frequently employed for extracellular matrix functionalization and to provide appropriate mechanical cues. It is challenging, however, to achieve structural integrity and retain bioactive molecules in hydrogels for complex tissue formation that may take months to develop. This work aims to investigate mechanical and biochemical characteristics of silk hydrogels for soft tissue engineering, specifi cally for the nervous system. The stiffness of 1 to 8% silk hydrogels, measured by atomic force microscopy, is 4 to 33 kPa. The structural integrity of silk gels is maintained throughout embryonic chick dorsal root ganglion (cDRG) explant culture over 4 days whereas fi brin and collagen gels decrease in mass over time. Neurite extension of cDRGs cultured on 2 and 4% silk hydrogels exhibit greater growth than softer or stiffer gels. Silk hydrogels release < 5% of neurotrophin-3 (NT-3) over 2 weeks and 11-day old gels show maintenance of growth factor bioactivity. Finally, fi bronectin-and NT-3-functionalized silk gels elicit increased axonal bundling suggesting their use in bridging nerve injuries. These results support silk hydrogels as soft and sustainable biomaterials for neural tissue engineering.

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Fabrication and characterization of the flexible neural microprobes with improved structural design

Cited by 43 publications

References 52 publications

Microneedles for drug and vaccine delivery

Microneedles for drug and vaccine delivery

A solid polymer microneedle patch pretreatment enhances the permeation of drug molecules into the skin

Silk Hydrogels as Soft Substrates for Neural Tissue Engineering

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