Fabrication and characterization of sertaconazole nitrate microsponge as a topical drug delivery system

Abstract

Pande, et al.: Formulation of Sertaconazole Nitrate MicrospongesPresent study was taken up to develop a topical formulation that releases the drug in controlled manner, reduce the side effects associated with topical drug delivery and improve product efficacy with aid of microsponges. Microsponges loaded with sertaconazole nitrate were prepared by using quasi emulsion solvent diffusion with five different proportions of the polymer (Eudragit RS 100). The developed microsponges were analyzed for particle size, production yield, entrapment efficiency and drug content. Scanning electron microscopic images of microsponges revealed that they are spherical in shape and contain pores. Pore structure analysis was done by using mercury intrusion porosimetry technique, which confirmed the porous nature of microsponges. Microsponges were then incorporated in to a 1% corbopol gel and evaluated for pH, drug content, texture profile analysis and in vitro drug release. The batch F IV was found to be optimal as it shown 69.38% controlled drug release in 8 h that followed Higuchi model.

Microsponge: A Novel Tool for Topical Drug Delivery of Anti Rheumatoid Drugs

“…Particle size and Particle size analysis can also be performed. Further, optical microscope can be connected with camera to capture the photograph of prepared Microsponge [42,43].…”

Microsponges as a Neoteric Cornucopia for Drug Delivery Systems

“…This is an extremely crucial step, as the size of the particles greatly affects the texture of the formulation and its stability. Particles larger than 30 μm [60][61][62] can impart gritty feeling and hence particles of sizes between 10 and 25 μm are preferred to use in a final topical formulation.…”

“…FTIR [56][57][58][59][60][61] spectroscopy is carried out for the pure drug, polymer and the drug-polymer physical mixture and microsponge formulations. The samples are incorporated in potassium bromide discs and evaluated.…”

Development of Clindamycin Loaded Oral Microsponges (Clindasponges) for Antimicrobial Enhancement: <i>In Vitro</i> Characterization and Simulated <i>in Vivo</i> Studies

“…Therefore, clindamycin has been one of the major interests for researchers though many years for the aim to improve the current marketed conventional formulations, they tried to incorporate it into multiple delivery systems like liposomes, nano-liposomes, nanofibers, nano-emulsion, and micro-emulsion to reduce its toxicity and antimicrobial activity [5][6][7].…”

“…Due to the small particle size of microsponges (particle size ranges from 5μm to 300μm), they can entrap high loads of drugs and exhibit unique compression and dissolution properties. Recently, microsponges have been designed to offer several advantages in pharmaceutical formulations, including delivering drugs to a specific target site of action [8,9], altering drugs' release patterns [10], enhancing drugs' stability [11] reducing drugs' mutagenicity and toxicity [12], encapsulating natural products and herbs [13], and improving the drug's penetration through skin layers for topical administration [14,15]. Furthermore, other researchers have prepared topical gels containing clindamycin microsponges to treat acne [16] and other infectious diseases [17].…”