Fabrication and characterization of remineralizing dental composites containing hydroxyapatite nanoparticles

Jardim, Renata Nunes; Rocha, Anderson A.; Rossi, Alexandre M.; Neves, Aline de Almeida; Portela, Maristela Barbosa; Lopes, Ricardo Tadeu; Santos, Thaís Maria Pires dos; Xing, Yutao; Silva, Eduardo Moreira da

doi:10.1016/j.jmbbm.2020.103817

Cited by 30 publications

(32 citation statements)

References 68 publications

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“…Alatawi et al, [ 91 ] observed improved compressive strength and antibacterial effect against Streptococcus mutans in addition to increased fluoride ion release. Jardim et al, [ 92 ] observed that dental composites with higher content of hydroxyapatite nanoparticles (HApNP) released higher amounts of Ca 2+ and PO 4 3− and the release rate was pH-dependent, i.e., they released higher amounts at pH 4 and 5.5 than at pH 7. Nano hydroxyapatite doped with strontium showed the formation of agglomerations instead of stable individual particles [ 93 ].…”

Section: Strategies For Interrupting Biofilm Formationmentioning

confidence: 99%

Bacterial adhesion to biomaterials: What regulates this attachment? A review

Kreve

Reis

2021

Japanese Dental Science Review

107

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Highlights Bacterial adhesion to the surface of dental materials play a significant role in infections. The factors that govern microbial attachment involves different types of physical-chemical interactions and biological processes. Studying bacterial adhesion makes it possible to understand the mechanisms involved in attachment and helps in the search for technologies that promote antibacterial surfaces.

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Section: Strategies For Interrupting Biofilm Formationmentioning

confidence: 99%

Bacterial adhesion to biomaterials: What regulates this attachment? A review

Kreve

Reis

2021

Japanese Dental Science Review

107

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“…The amorphous structure and chemical composition of ACP, the direct precursor of HA [ 6 ], cause the formation of high concentrations of ions in aqueous solutions [ 7 ]. In order to increase the remineralization potential, bioactive dental composites usually contain CaPs in the form of nanoparticles [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

The Beneficial Role of Filipendula ulmaria Extract in Prevention of Prodepressant Effect and Cognitive Impairment Induced by Nanoparticles of Calcium Phosphates in Rats

Arsenijevic

Selaković

Stanković

et al. 2021

Oxidative Medicine and Cellular Longevity

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Mineral components of dental composites are used in many medical and dental applications, including preventive, restorative, and regenerative dentistry. To evaluate the behavioural alterations induced by nanosized particles of novel dental composites, by means of depressive level and cognitive functions, experimental groups of rats were chronically administered with nanosized hydroxyapatite (HA), tricalcium phosphate (TCP), and amorphous calcium phosphate (ACP) with or without simultaneous application of Filipendula ulmaria L. (FU) methanolic extract. The significant prodepressant action was observed in groups solely treated with HA and ACP. Besides, prolonged treatment with ACP also resulted in a significant decline in cognitive functions estimated in the novel object recognition test. The adverse impact of calcium phosphates on estimated behavioural functions was accompanied by increased oxidative damage and apoptotic markers in the prefrontal cortex, as well as diminished specific neurotrophin (BDNF) and gabaergic expression. The results of our investigation showed that simultaneous antioxidant supplementation with FU extract prevented calcium phosphate-induced behavioural disturbances, as well as prooxidative and apoptotic actions, with the simultaneous restoration of BDNF and GABA-A receptors in the prefrontal cortex. These findings suggest that FU may be useful in the prevention of prodepressant impact and cognitive decline as early as the manifestation of calcium phosphate-induced neurotoxicity.

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“…In addition to daily oral hygiene, another approach to the issue of preventing secondary caries could be from the incorporation of particles of hydroxyapatite into restorative dental materials, as was done for glass-ionomer cements [ 27 ] determining an improvement on shear bond strength and flexural strength values, and for composite resin [ 28 ] leading to calcium and phosphate release under acidic circumstances, not without alterations of physical-chemical properties of the restorative material. Particles of hydroxyapatite have been added to resin-modified glass-ionomer cements, resulting in a reduction of the microleakage if compared to conventional glass-ionomer cements [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

SEM/EDS Evaluation of the Mineral Deposition on a Polymeric Composite Resin of a Toothpaste Containing Biomimetic Zn-Carbonate Hydroxyapatite (microRepair®) in Oral Environment: A Randomized Clinical Trial

et al. 2021

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Toothpastes containing biomimetic hydroxyapatite have been investigated in recent years; the behavior of this material in the oral environment has been evaluated directly on dental enamel showing a marked remineralizing activity. To propose microRepair®-based toothpastes (Zn-carbonate hydroxyapatite) for the domiciliary oral hygiene in patients with dental composite restorations, the aim of this study was to evaluate the deposition of Zn-carbonate hydroxyapatite on a polymeric composite resin with Scanning Electron Microscopy/Energy-Dispersive X-ray Spectrometry (SEM/EDS) analysis. Twenty healthy volunteers underwent the bonding of 3 orthodontic buttons on the vestibular surfaces of upper right premolars and first molar. On the surface of the buttons, a ball-shaped mass of composite resin was applied and light-cured. Then, the volunteers were randomly divided into two groups according to the toothpaste used for domiciliary oral hygiene: the Control toothpaste containing stannous fluoride and the Trial toothpaste containing microRepair®. The buttons were debonded after 7 days (T1—first premolar), after 15 days (T2—second premolar), and after 30 days (T3—first molar) to undergo the SEM/EDS analysis. The deposition of calcium, phosphorus, and silicon was assessed through EDS analysis and data were submitted to statistical analysis (p < 0.05). SEM morphologic evaluation showed a marked deposition of the two toothpastes on the surfaces of the buttons. EDS quantitative analysis showed an increase of calcium, phosphorus, and silicon in both the groups, with a statistically significant difference of calcium deposition at T3 for the Trial group. Therefore, the use of toothpaste containing Zn-carbonate hydroxyapatite could be proposed as a device for domiciliary oral hygiene because the deposition of hydroxyapatite on polymeric composite resin could prevent secondary caries on the margins of restorations.

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Fabrication and characterization of remineralizing dental composites containing hydroxyapatite nanoparticles

Cited by 30 publications

References 68 publications

Bacterial adhesion to biomaterials: What regulates this attachment? A review

Bacterial adhesion to biomaterials: What regulates this attachment? A review

The Beneficial Role of Filipendula ulmaria Extract in Prevention of Prodepressant Effect and Cognitive Impairment Induced by Nanoparticles of Calcium Phosphates in Rats

SEM/EDS Evaluation of the Mineral Deposition on a Polymeric Composite Resin of a Toothpaste Containing Biomimetic Zn-Carbonate Hydroxyapatite (microRepair®) in Oral Environment: A Randomized Clinical Trial

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