Fabrication and characterization of PVA@PLA electrospinning nanofibers embedded with Bletilla striata polysaccharide and Rosmarinic acid to promote wound healing

Zhong, Guofeng; Qiu, Mengyu; Zhang, Junbo; Jiang, Fuchen; Xuan, Yue; Huang, Chi Ming; Zhao, Shuang; Zeng, Rui; Zhang, Chen; Qu, Yan

doi:10.1016/j.ijbiomac.2023.123693

Cited by 44 publications

(26 citation statements)

References 59 publications

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“…However, the interesting and reassuring finding was observed after 3 days of co-culture. The cellular activity of the PLA fibers increased significantly to 100.1%, indicating complete recovery and proliferation of the cells . Similarly, the antibacterial PLA-based fibers showed a cellular activity of 93.1%, indicating a substantial recovery as well (Figures and S24).…”

Section: Resultsmentioning

confidence: 83%

“…The cellular activity of the PLA fibers increased significantly to 100.1%, indicating complete recovery and proliferation of the cells. 47 Similarly, the antibacterial PLAbased fibers showed a cellular activity of 93.1%, indicating a substantial recovery as well (Figures 5 and S24). This robust increase in cell activity clearly suggests that the antibacterial PLA-based fibers support cell growth and proliferation, demonstrating their compatibility with the L929 cells.…”

Section: Antibacterialmentioning

confidence: 80%

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Improved Antibacterial Properties of Polylactic Acid-Based Nanofibers Loaded with ZnO–Ag Nanoparticles through Pore Engineering

Su,

Zhai,

Jia

et al. 2023

ACS Appl. Mater. Interfaces

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In the post-epidemic era, bio-based protective fiber materials with active protective functions are of utmost importance, not only to combat the spread of pathogens but also to reduce the environmental impact of petroleum-based protective materials. Here, efficient antibacterial polylactic acid-based (PLA-based) fibers are prepared by solution blow spinning and their pore structures are regulated by controlling the ratio of the solvent components in the spinning solutions. The porous PLA-based fibers exhibit antibacterial efficiencies of over 99% against Escherichia coli and over 98% against Bacillus subtilis, which are significantly higher than that of the nonporous PLA-based fibers. The excellent antibacterial property of the porous PLA-based fibers can be attributed to their high porosity, which allows antibacterial nanoparticles to be released more easily from the fibers, thus effectively killing pathogenic microorganisms. Moreover, pore structure regulation can also enhance the mechanical property of the PLA-based fiber materials. Our approach of regulating the microstructure and properties of the PLA-based fibers through pore engineering can be extended to other polymer fiber materials and is suitable for polymer-based composite systems that require optimal performance through sufficient exposure of doped materials.

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Section: Resultsmentioning

confidence: 83%

Section: Antibacterialmentioning

confidence: 80%

Improved Antibacterial Properties of Polylactic Acid-Based Nanofibers Loaded with ZnO–Ag Nanoparticles through Pore Engineering

Su,

Zhai,

Jia

et al. 2023

ACS Appl. Mater. Interfaces

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“…[102] Poly vinyl alcohol and poly lactic acids are effective biodegradable copolymers that are approved by the Food and Drug Administration for biomedical applications. [103] Atanasio Pet al prepared nanoparticles using functionalized polylactic acid polyethylene glycol loaded bevacizumab and immune uterine globulin-1. By attaching specific target molecules (such as antibodies, ligands or receptors) to the surface of nanoparticles, the stability and targeting of the nanoparticles is improved.…”

Section: Other Polymeric Nanomaterialsmentioning

confidence: 99%

Recent Advances in Anti‐Atherosclerosis and Potential Therapeutic Targets for Nanomaterial‐Derived Drug Formulations

Xiao,

Li,

Xiong

et al. 2023

Advanced Science

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Atherosclerosis, the leading cause of death worldwide, is responsible for ≈17.6 million deaths globally each year. Most therapeutic drugs for atherosclerosis have low delivery efficiencies and significant side effects, and this has hampered the development of effective treatment strategies. Diversified nanomaterials can improve drug properties and are considered to be key for the development of improved treatment strategies for atherosclerosis. The pathological mechanisms underlying atherosclerosis is summarized, rationally designed nanoparticle‐mediated therapeutic strategies, and potential future therapeutic targets for nanodelivery. The content of this study reveals the potential and challenges of nanoparticle use for the treatment of atherosclerosis and highlights new effective design ideas.

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“…The ideal dressing absorbs excess inflammatory secretions to provide a moist healing environment for the wound. In addition, the dressing should have antibacterial, antioxidant, biocompatible, biodegradable, and facile separation from the wound surface qualities 10,11 . Furthermore, wound dressings should enhance wound adhesion because nonadhesion sites are ideal for fluid collection and bacterial development 12 …”

Section: Introductionmentioning

confidence: 99%

“…In addition, the dressing should have antibacterial, antioxidant, biocompatible, biodegradable, and facile separation from the wound surface qualities. 10,11 Furthermore, wound dressings should enhance wound adhesion because nonadhesion sites are ideal for fluid collection and bacterial development. 12 According to the numerous criteria mentioned, it is quite clear that no substance alone can fulfill all the wound healing requirements.…”

mentioning

confidence: 99%

Electrospun nylon 6/hyaluronic acid/chitosan bioactive nanofibrous composite as a potential antibacterial wound dressing

Foroozandeh,

Shakiba,

Zamani

et al. 2024

J Biomed Mater Res

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Hyaluronic acid (HA) and chitosan (CS), as natural biomaterials, display excellent biocompatibility and stimulate the growth and proliferation of fibroblasts. Furthermore, nylon 6 (N6) is a low‐cost polymer with good compatibility with human tissues and high mechanical stability. In this study, HA and CS were applied to modify N6 nanofibrous mat (N6/HA/CS) for potential wound dressing. N6/HA/CS nanofibrous composite mats were developed using a simple one‐step electrospinning technique at different CS concentrations of 1, 2, and 3 wt%. The results demonstrated that incorporating HA and CS into N6 resulted in increased hydrophilicity, as well as favorable physical and mechanical properties. In addition, the minimum inhibitory concentration and (MIC) optical density techniques were used to determine the antibacterial properties of N6/HA/CS nanofibrous composite mats, and the results demonstrated that the composites could markedly inhibit the growth of Gram‐positive bacteria Staphylococcus aureus and Gram‐negative bacteria Escherichia coli. Because of its superior mechanical properties, substantial antimicrobial effects, and hydrophilic surface, N6/HA/CS at 2 wt% of CS (N6/HA/CS2) was chosen as the most suitable nanofibrous mat. The swelling, porosity, gel content, and in vitro degradation studies imply that N6/HA/CS2 nanofibrous composite mat has proper moisture retention and biodegradability. Furthermore, the N6/HA/CS2 nanofibrous composite mat was discovered to be nontoxic to L929 fibroblast cells and to even improve cell proliferation. Based on the findings, this research offers a simple and rapid method for creating material that could be utilized as prospective wound dressings in clinical environments.

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Fabrication and characterization of PVA@PLA electrospinning nanofibers embedded with Bletilla striata polysaccharide and Rosmarinic acid to promote wound healing

Cited by 44 publications

References 59 publications

Improved Antibacterial Properties of Polylactic Acid-Based Nanofibers Loaded with ZnO–Ag Nanoparticles through Pore Engineering

Improved Antibacterial Properties of Polylactic Acid-Based Nanofibers Loaded with ZnO–Ag Nanoparticles through Pore Engineering

Recent Advances in Anti‐Atherosclerosis and Potential Therapeutic Targets for Nanomaterial‐Derived Drug Formulations

Electrospun nylon 6/hyaluronic acid/chitosan bioactive nanofibrous composite as a potential antibacterial wound dressing

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