Fabrication and Characterization of Polymer Hollow Microneedle Array Using UV Lithography Into Micromolds

Wang, Po-Chun; Paik, Seung-Joon; Chen, Shuodan; Rajaraman, Swaminathan; Kim, Seong-Hyok; Allen, Mark G.

doi:10.1109/jmems.2013.2262587

Cited by 29 publications

(25 citation statements)

References 33 publications

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“…Hollow microneedles are made of various materials, including glass [46], nickel [140], stainless steel [14], and polymers such as SU-8 and poly-glycolic acid [55,[141][142][143][144][145], as shown in Figure 6 (a) and 6 (b). Safety of materials used for hollow microneedles are summarized in Table 6.…”

Section: Safety Of Hollow Microneedlesmentioning

confidence: 99%

Considerations in the use of microneedles: pain, convenience, anxiety and safety

Jeong

Lee

Choi

et al. 2016

Journal of Drug Targeting

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Transdermal delivery using microneedles is gaining increasing attention from pharmaceutical and cosmetic companies as one of the promising drug delivery methods. Microneedle products have recently become available on the market, and some of them are under evaluation for efficacy and safety. To be available in the market for cosmetic and therapeutic use, several factors should be considered, including pain, anxiety, convenience and safety. These factors are summarized and reviewed in this article according to type of microneedle. Various kinds of materials have been used for manufacturing microneedles and developing drug formulations for microneedles. Safety information about materials used for microneedles is summarized in terms of type of microneedles. In addition to their biocompatibility, mechanical safety is also discussed. This review can provide guidelines for designing microneedle products for proper use.

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Section: Safety Of Hollow Microneedlesmentioning

confidence: 99%

Considerations in the use of microneedles: pain, convenience, anxiety and safety

Jeong

Lee

Choi

et al. 2016

Journal of Drug Targeting

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“…Metal microneedle structures are often formed using an electroplating process onto a seeding layer that is predefined by a polymer micromold 14 . Polymer 3D microneedle structures are created using stainless steel molding technology 15 , inclined ultraviolet (UV) exposure technology 16 , polydimethylsiloxane molding technology 17,18 , and etched lens backside exposure technology 19 . Because these approaches require special equipment or platforms, microneedle structures that are fabricated either by assembling 2D probe combs or etching bulk materials are expensive and time consuming.…”

Section: Introductionmentioning

confidence: 99%

A flexible three-dimensional electrode mesh: An enabling technology for wireless brain–computer interface prostheses

2016

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The neural interface is a key component in wireless brain-computer prostheses. In this study, we demonstrate that a unique three-dimensional (3D) microneedle electrode on a flexible mesh substrate, which can be fabricated without complicated micromachining techniques, is conformal to the tissues with minimal invasiveness. Furthermore, we demonstrate that it can be applied to different functional layers in the nervous system without length limitation. The microneedle electrode is fabricated using drawing lithography technology from biocompatible materials. In this approach, the profile of a 3D microneedle electrode array is determined by the design of a two-dimensional (2D) pattern on the mask, which can be used to access different functional layers in different locations of the brain. Due to the sufficient stiffness of the electrode and the excellent flexibility of the mesh substrate, the electrode can penetrate into the tissue with its bottom layer fully conformal to the curved brain surface. Then, the exposed contact at the end of the microneedle electrode can successfully acquire neural signals from the brain. INTRODUCTIONBrain-computer prostheses provide a bridge for humans to understand and communicate with the nervous system. Neural interfaces are a key component enabling wireless brain-computer prostheses for long-term implantation. In the last decades, researchers have developed various types of neural interfaces based on advanced functional materials and fabrication technology [1][2][3] . Because a two-dimensional (2D) structure can be shaped precisely and easily, most neural interfaces are fabricated into planar geometries, which are known as neural probes. However, neural tissues are normally three-dimensional (3D) structures, and 2D neural probes are limited to recording signals from only planar brain regions

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“…Wang et al developed a polymer-based process for fabricating microneedles using UV lithography. 17 A hollow microneedle array and baseplate, in which needle lumens extend through the thickness of the baseplate, were demonstrated. Izumi et al proposed a biodegradable polymer needle with a sharp tip using a micromolding technique was proposed.…”

Section: Introductionmentioning

confidence: 99%

Polymer-based disposable microneedle array with insertion assisted by vibrating motion

Lee

Hung

et al. 2016

Biomicrofluidics

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This work presents a disposable polymer-based microneedle array that carries out insertions by mimicking the vibrating motion of a mosquito's proboscis. The proposed device, which comprises a 10:1 high-aspect-ratio parylene microneedle array and a chamber structure, was monolithically realized using a novel fabrication process. The vibrating motion of the microneedles was generated using a piezoelectric actuator. This device can be potentially applied to extract and collect blood by puncturing the dermis layer of human skin. The fabricated device is advantageous because of its biocompatibility, simple fabrication process, and low associated costs. Additionally, the graph of the measured extraction flow rate versus the pressure drop that is presented shows an agreement with the results predicted by analytical models. A 40% reduction of insertion force was demonstrated when the microneedle insertion was assisted by actuator-induced vibratory motions. Buckling analyses for estimating the maximum loads that the microneedle can sustain before failure occurs were also evaluated. Finally, the relationship between the insertion force and the vibration frequency was demonstrated in this study. V C 2016 AIP Publishing LLC. [http://dx

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Fabrication and Characterization of Polymer Hollow Microneedle Array Using UV Lithography Into Micromolds

Cited by 29 publications

References 33 publications

Considerations in the use of microneedles: pain, convenience, anxiety and safety

Considerations in the use of microneedles: pain, convenience, anxiety and safety

A flexible three-dimensional electrode mesh: An enabling technology for wireless brain–computer interface prostheses

Polymer-based disposable microneedle array with insertion assisted by vibrating motion

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