Fabrication and Characterization of PLA-PGA Orthopedic Implants

Agrawal, C. Mauli; Niederauer, G. G.; Athanasiou, Kyriacos A.

doi:10.1089/ten.1995.1.241

Cited by 73 publications

(38 citation statements)

References 55 publications

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“…Biodegradable poly(α-hydroxy ester) polymers, including poly(lactide-co-glycolide) (PLAGA), have been used extensively for fabrication of 3D scaffold biomaterials utilized in tissue engineering due to their commercial availability, excellent biocompatibility, and prior FDA approval for a number of clinical applications [43]. These synthetic biomaterials can circumvent limitations of systemic delivery by sustaining release and bioavailability of a growth factor within target tissues without systemic and/or dose-related toxicity.…”

Section: Discussionmentioning

confidence: 99%

Sustained release of sphingosine 1-phosphate for therapeutic arteriogenesis and bone tissue engineering

et al. 2008

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Sphingosine 1-phosphate (S1P) is a bioactive phospholipid that impacts migration, proliferation, and survival in diverse cells types, including endothelial cells, smooth muscle cells, and osteoblast-like cells. In this study, we investigated the effects of sustained release of S1P on microvascular remodeling and associated bone defect healing in vivo. The murine dorsal skinfold window chamber model was used to evaluate the structural remodeling response of the microvasculature. Our results demonstrated that 1:400 (w/w) loading and subsequent sustained release of S1P from poly(lactic-coglycolic acid) (PLAGA) significantly enhanced lumenal diameter expansion of arterioles and venules after 3 and 7 days. Incorporation of 5-bromo-2-deoxyuridine (BrdU) at day 7 revealed significant increases in mural cell proliferation in response to S1P delivery. Additionally, three-dimensional (3D) scaffolds loaded with S1P (1:400) were implanted into critical-size rat calvarial defects and healing of bony defects was assessed by radiograph x-ray, microcomputed tomography (μCT), and histology. Sustained release of S1P significantly increased the formation of new bone after 2 and 6 weeks of healing and histological results suggest increased numbers of blood vessels in the defect site. Taken together, these experiments support the use of S1P delivery for promoting microvessel diameter expansion and improving the healing outcomes of tissue-engineered therapies.

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Section: Discussionmentioning

confidence: 99%

Sustained release of sphingosine 1-phosphate for therapeutic arteriogenesis and bone tissue engineering

et al. 2008

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“…In a study done on rats, the PLA implants were labeled with radioactive carbon and placed internally in rats for 3 months, as a result there was no significant radio activity found in the urine or feces, which confirmed that the polymer is degraded and probably eliminated through CO 2 during respiration. Further, PGA can be broken down in two ways, by hydrolysis sand by nonspecific esterase and carboxypeptidases (Agrawal et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

“…Hence, the PLA is used as a biopolymer, which would biodegradable and is nontoxic to humans. Another reason is that, PLA could be fermented easily using natural fermentation process, thus it is considerably low cost compared few metal implants (Agrawal et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Production and Detection of L-(+)-Lactic Acid Using Cassava as the Low Cost Fermentation Medium for the Synthesis of Biodegradable Polymers as Orthopedic Devices

Selvaraj¹,

Gunesekera²,

Gunathilaka³

et al. 2017

International Conference on Bioscience and Biotechnology

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Abstract:Polymers based on Lactic acid are of great importance to the healthcare industry because they decompose by hydrolysis in the human body in to nontoxic metabolites. Therefore, the objective of the current study was to produce L-(+)-Lactic acid using a low cost medium in order to synthesize a biodegradable polymer for healthcare industry. Powdered cassava was acid hydrolyzed using different concentration of HCl (0.5, 1, 1.5, 2, 2.

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“…Polymers belonging to the PLA-PGA family are now widely used for fabricating implantable drug delivery systems and fracture fixation devices for orthopedics applications. 17 These materials are popular because they are reasonably biocompatible 18 and their structure-property relationships have been examined in detail. [19][20][21] In addition, their in vivo and in vitro biodegradation characteristics also have been studied extensively.…”

Section: Methodsmentioning

confidence: 99%

Porous-coated titanium implant impregnated with a biodegradable protein delivery system

Agrawal

Pennick

Wang

et al. 1997

J. Biomed. Mater. Res.

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Tissue ingrowth into porous-coated orthopedic and dental implants is commonly used as a means to achieve long-term fixation of these prostheses. However, the degree of tissue ingrowth is often inadequate and inconsistent. If the pores of these implants are impregnated with a controlled drug release system delivering relevant growth factors, then it might be possible to stimulate more tissue ingrowth. The present study introduces such a system based on biodegradable polymers and investigates its protein release profile and polymer degradation characteristics. Porous coated titanium implants were impregnated with a mixture of a 50%-50% polylactic acid-polyglycolic acid copolymer and a model protein, soybean trypsin inhibitor. Control implants contained only the polymer and no protein. The implants were subjected to hydrolytic degradation in phosphate buffered saline at 37 degrees C for periods of 3, 6, and 11 weeks. The protein release and the mass and molecular weight of the polymer were monitored. The results indicate that the protein is released in three distinct phases and the polymer loses almost all its mass and molecular weight by 11 weeks. There was a significant difference in the polymer degradation characteristics between the control and test implants, which might be the result of some complex polymer-protein interactions.

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Fabrication and Characterization of PLA-PGA Orthopedic Implants

Cited by 73 publications

References 55 publications

Sustained release of sphingosine 1-phosphate for therapeutic arteriogenesis and bone tissue engineering

Sustained release of sphingosine 1-phosphate for therapeutic arteriogenesis and bone tissue engineering

Production and Detection of L-(+)-Lactic Acid Using Cassava as the Low Cost Fermentation Medium for the Synthesis of Biodegradable Polymers as Orthopedic Devices

Porous-coated titanium implant impregnated with a biodegradable protein delivery system

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