Fabrication and characterization of low-cost freeze-gelated chitosan/collagen/hydroxyapatite hydrogel nanocomposite scaffold

Kaviani, Alireza; Zebarjad, Seyed Mojtaba; Javadpour, Sirus; Ayatollahi, Maryam; Bazargan‐Lari, Reza

doi:10.1080/1023666x.2018.1562477

Cited by 47 publications

(26 citation statements)

References 40 publications

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“…Therefore, all exudates in and around the wound should be removed by means of appropriate drainage methods. This makes up another main criterion for a wound dressing, where the drainage capacity of the dressing should be high enough and appropriate to the size and type of the wound on which it will be placed [ 107 ]. For all types of skin lesion, there is a gold standard that wound dressings should strive for.…”

Section: Wound Treatmentmentioning

confidence: 99%

Recent Advances and Applications of Bacterial Cellulose in Biomedicine

et al. 2021

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Bacterial cellulose (BC) is an extracellular polymer produced by Komagateibacter xylinus, which has been shown to possess a multitude of properties, which makes it innately useful as a next-generation biopolymer. The structure of BC is comprised of glucose monomer units polymerised by cellulose synthase in β-1-4 glucan chains which form uniaxially orientated BC fibril bundles which measure 3–8 nm in diameter. BC is chemically identical to vegetal cellulose. However, when BC is compared with other natural or synthetic analogues, it shows a much higher performance in biomedical applications, potable treatment, nano-filters and functional applications. The main reason for this superiority is due to the high level of chemical purity, nano-fibrillar matrix and crystallinity. Upon using BC as a carrier or scaffold with other materials, unique and novel characteristics can be observed, which are all relatable to the features of BC. These properties, which include high tensile strength, high water holding capabilities and microfibrillar matrices, coupled with the overall physicochemical assets of bacterial cellulose makes it an ideal candidate for further scientific research into biopolymer development. This review thoroughly explores several areas in which BC is being investigated, ranging from biomedical applications to electronic applications, with a focus on the use as a next-generation wound dressing. The purpose of this review is to consolidate and discuss the most recent advancements in the applications of bacterial cellulose, primarily in biomedicine, but also in biotechnology.

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Section: Wound Treatmentmentioning

confidence: 99%

Recent Advances and Applications of Bacterial Cellulose in Biomedicine

et al. 2021

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“…However, their prolonged administration causes many side effects. In more advanced stages of the disease and due to the limited capacity for self-repair, replacement or induced regeneration of the damaged area is often required [ 3 ]. To date, different treatment methods have been designed, such as mosaicplasty, osteochondral allograft transplantation, and autologous chondrocyte implantation, among others.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Evaluation of AlgNa-g-Poly(QCL-co-HEMA) Hydrogels as Platform for Chondrocyte Proliferation and Controlled Release of Betamethasone

García-Couce

Vernhes

Bada

et al. 2021

IJMS

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Hydrogels obtained from combining different polymers are an interesting strategy for developing controlled release system platforms and tissue engineering scaffolds. In this study, the applicability of sodium alginate-g-(QCL-co-HEMA) hydrogels for these biomedical applications was evaluated. Hydrogels were synthesized by free-radical polymerization using a different concentration of the components. The hydrogels were characterized by Fourier transform-infrared spectroscopy, scanning electron microscopy, and a swelling degree. Betamethasone release as well as the in vitro cytocompatibility with chondrocytes and fibroblast cells were also evaluated. Scanning electron microscopy confirmed the porous surface morphology of the hydrogels in all cases. The swelling percent was determined at a different pH and was observed to be pH-sensitive. The controlled release behavior of betamethasone from the matrices was investigated in PBS media (pH = 7.4) and the drug was released in a controlled manner for up to 8 h. Human chondrocytes and fibroblasts were cultured on the hydrogels. The MTS assay showed that almost all hydrogels are cytocompatibles and an increase of proliferation in both cell types after one week of incubation was observed by the Live/Dead® assay. These results demonstrate that these hydrogels are attractive materials for pharmaceutical and biomedical applications due to their characteristics, their release kinetics, and biocompatibility.

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“…The use of natural polymers such as polysaccharides for developing of these matrices has been frequently studied for past decades. Chitosan, hyaluronic acid, and sodium alginate are among the most widely used [3]. Sodium alginate is a linear anionic polysaccharide, composed by B-D mannuronic acid and a-L-guluronic acid units, obtained mainly from brown marine algae [8,9].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and evaluation of AlgNa-g-poly(QCL-co-HEMA) hydrogels for cartilage tissue engineering and controlled release of betamethasone.

García-Couce¹,

Vernhes²,

Bada³

et al. 2021

Preprint

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Hydrogels obtained from the combination of different polymers are an interesting strategy for the development of controlled release system platforms and tissue engineering scaffolds. In this study, the applicability of sodium alginate-g-(QCL-co-HEMA) hydrogels for these biomedical applications was evaluated. Hydrogels were synthesized by free-radical polymerization using different concentration of the components. The hydrogels were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, and swelling degree; betamethasone release as well as the in vitro cytocompatibility with chondrocytes and fibroblast cells were also evaluated. Scanning electron microscopy confirmed the porous surface morphology of the hydrogels in all cases. The swelling percent was determined at different pH and was observed to be pH-sensitive. The controlled release behavior of betamethasone from the matrices was investigated in PBS media (pH = 7.4) and the drug was released in a controlled manner up to 8 h. Human chondrocytes and fibroblasts were cultured on the hydrogels. The MTS assay shown that almost all hydrogels are cytocompatibles and an increase the proliferation in both cell types after one week of incubation was observed by Live/Dead® assay. These results demonstrate that these hydrogels are attractive materials for pharmaceutical and biomedical applications due to their characteristics, their release kinetics and biocompatibility.

show abstract

Fabrication and characterization of low-cost freeze-gelated chitosan/collagen/hydroxyapatite hydrogel nanocomposite scaffold

Cited by 47 publications

References 40 publications

Recent Advances and Applications of Bacterial Cellulose in Biomedicine

Recent Advances and Applications of Bacterial Cellulose in Biomedicine

Synthesis and Evaluation of AlgNa-g-Poly(QCL-co-HEMA) Hydrogels as Platform for Chondrocyte Proliferation and Controlled Release of Betamethasone

Synthesis and evaluation of AlgNa-g-poly(QCL-co-HEMA) hydrogels for cartilage tissue engineering and controlled release of betamethasone.

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