Fabrication and characterization of hydroxyapatite/sodium alginate/chitosan composite microspheres for drug delivery and bone tissue engineering

Bi, Yutie; Lin, Ziting; Deng, Shi-Ting

doi:10.1016/j.msec.2019.03.040

Cited by 141 publications

(88 citation statements)

References 40 publications

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“…For example, in drug delivery field, Bi and colleagues tested sodium alginate microspheres that, combined with chitosan and hydroxyapatite, have been loaded with doxorubicin hydrochloride drug. In vitro results validated the implied microspheres as a promising support for bone regeneration and controlled drug release system [94]. Other researchers used the alginate microspheres to encapsulate and protect the human umbilical cord mesenchymal stem cells.…”

Section: Natural Polymersmentioning

confidence: 73%

Natural and Synthetic Polymers for Bone Scaffolds Optimization

et al. 2020

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Bone tissue is the structural component of the body, which allows locomotion, protects vital internal organs, and provides the maintenance of mineral homeostasis. Several bone-related pathologies generate critical-size bone defects that our organism is not able to heal spontaneously and require a therapeutic action. Conventional therapies span from pharmacological to interventional methodologies, all of them characterized by several drawbacks. To circumvent these effects, tissue engineering and regenerative medicine are innovative and promising approaches that exploit the capability of bone progenitors, especially mesenchymal stem cells, to differentiate into functional bone cells. So far, several materials have been tested in order to guarantee the specific requirements for bone tissue regeneration, ranging from the material biocompatibility to the ideal 3D bone-like architectural structure. In this review, we analyse the state-of-the-art of the most widespread polymeric scaffold materials and their application in in vitro and in vivo models, in order to evaluate their usability in the field of bone tissue engineering. Here, we will present several adopted strategies in scaffold production, from the different combination of materials, to chemical factor inclusion, embedding of cells, and manufacturing technology improvement.

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Section: Natural Polymersmentioning

confidence: 73%

Natural and Synthetic Polymers for Bone Scaffolds Optimization

et al. 2020

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“…However, the actual process of the material in vivo has not been studied. The results indicate that the hydroxyapatite/ alginate hydrogel microsphere has potential in bone healing and as a drug carrier [40].…”

Section: Bonementioning

confidence: 84%

“…Sodium alginate can be easily manufactured in microspheres with threedimensional net structures using cross-linking with calcium ions [40]. Hydrogels formed as microspheres possess some advantages for use in biomedical applications because of the larger specific surface area that can improve cell adhesion, proliferation and drug delivery.…”

Section: Bonementioning

confidence: 99%

“…Hydrogels formed as microspheres possess some advantages for use in biomedical applications because of the larger specific surface area that can improve cell adhesion, proliferation and drug delivery. Bi et al [40] obtained sodium alginate microspheres with the addition of chitosan (CS) and hydroxyapatite. Doxorubicin hydrochloride (Dox) was used as a drug model to study the drug loading behaviour of HA nanoparticles and hydrogel composite microspheres.…”

Section: Bonementioning

confidence: 99%

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Alginate-Based Hydrogels in Regenerative Medicine

Kaczmarek-Pawelska¹

2020

Alginates - Recent Uses of This Natural Polymer

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This chapter presents the following multipotential applications of alginatebased hydrogels in tissue healing and drug delivery. It contains state of the art and summary of the literature reports, which demonstrate that alginate-based hydrogels have a great potential in tissue healing. Sodium alginate (SA) is mainly used in medical devices for healing of wounds, scars, injuries of bones, regeneration of joint cartilage, and scaffold for cell growth and in drug delivery systems (DDSs). The latest literature describes the effects of laboratory tests and in vivo, which confirm the validity of its use as a biomaterial. Alginate biodegradable scaffolds can be a template that provides a suitable substrate for cellular growth while matching the physiochemical properties of the native extracellular matrix (ECM). Matching scaffold stiffness to the surrounding tissue and optimising its rate of degradation ensure that the infiltrating cells remain viable, maintain their desired phenotype and coordinate their response over the entirety of the wound healing process.

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“…Doxycycline-incorporated hydroxyapatite/chitosan/sodium alginate composites showed an effective pH-responsive release of drugs and found to be cell and blood compatible. Moreover, the newly synthesized microspheres presented superior cell adhesive and propagation capability compared with HA-based NPs and HA/SA bio-composite microbeads [35].…”

Section: Targeted Drug Deliverymentioning

confidence: 97%

Marine Seaweed Polysaccharides-Based Engineered Cues for the Modern Biomedical Sector

Bilal

Iqbal

2019

Marine Drugs

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Seaweed-derived polysaccharides with unique structural and functional entities have gained special research attention in the current medical sector. Seaweed polysaccharides have been or being used to engineer novel cues with biomedical values to tackle in practice the limitations of counterparts which have become ineffective for 21st-century settings. The inherited features of seaweed polysaccharides, such as those of a biologically tunable, biocompatible, biodegradable, renewable, and non-toxic nature, urge researchers to use them to design therapeutically effective, efficient, controlled delivery, patient-compliant, and age-compliant drug delivery platforms. Based on their significant retention capabilities, tunable active units, swelling, and colloidal features, seaweed polysaccharides have appeared as highly useful materials for modulating drug-delivery and tissue-engineering systems. This paper presents a standard methodological approach to review the literature using inclusion-exclusion criteria, which is mostly ignored in the reported literature. Following that, numerous marine-based seaweed polysaccharides are discussed with suitable examples. For the applied perspectives, part of the review is focused on the biomedical values, i.e., targeted drug delivery, wound-curative potential, anticancer potentialities, tissue-engineering aspects, and ultraviolet (UV) protectant potential of seaweed polysaccharides based engineered cues. Finally, current challenges, gaps, and future perspectives have been included in this review.

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Fabrication and characterization of hydroxyapatite/sodium alginate/chitosan composite microspheres for drug delivery and bone tissue engineering

Cited by 141 publications

References 40 publications

Natural and Synthetic Polymers for Bone Scaffolds Optimization

Natural and Synthetic Polymers for Bone Scaffolds Optimization

Alginate-Based Hydrogels in Regenerative Medicine

Marine Seaweed Polysaccharides-Based Engineered Cues for the Modern Biomedical Sector

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