Fabrication and characterization of hydrophilic poly(lactic-co-glycolic acid)/poly(vinyl alcohol) blend cell scaffolds by melt-molding particulate-leaching method

Oh, Se Heang; Kang, Soung Gon; Kim, Eun Seok; Cho, Sang-Ho; Lee, Jin Ho

doi:10.1016/s0142-9612(03)00284-9

Cited by 347 publications

(210 citation statements)

References 43 publications

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“…Briefly, the melt-molding step consists in premixing polymer powder and solid porogen particulates and hot-pressing them together. The samples are then subjected to the same solid porogen leaching step as for the solvent-cast samples [26][27][28][29]. In a general manner, the major advantage of particulate leaching methods is the effective control of porosity and pore size.…”

Section: Introductionmentioning

confidence: 99%

Preparation of interconnected poly(ε-caprolactone) porous scaffolds by a combination of polymer and salt particulate leaching

Reignier

Huneault

2006

Polymer

215

161

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Section: Introductionmentioning

confidence: 99%

Preparation of interconnected poly(ε-caprolactone) porous scaffolds by a combination of polymer and salt particulate leaching

Reignier

Huneault

2006

Polymer

215

161

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“…It is due to the fact that hydrophilic polymer surfaces enhance biocompatibility of polymeric materials. The suitable hydrophilic profile of the scaffold surface enables cells adhesion, migration and proliferation [26]. A number of cellular scaffolds for all types of tissues was developed from natural (chitosan, elastin, alginate, collagen) and/or synthetic (polyglycolide (PGA), polylactide (PLA), PUR) polymers or even from ceramic materials (hydrokxyapatite, bioglass) [27].…”

Section: Tissue Engineering Scaffoldsmentioning

confidence: 99%

Ascorbic Acid in Polyurethane Systems for Tissue Engineering

Kucińska-Lipka¹,

St.²,

Janik³

et al. 2016

ChChT

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Abstract. The introduction of the paper was devoted to the main items of Tissue Engineering (TE) and the way of porous structure obtaining as scaffolds. Furthermore, the significant role of the scaffold design in TE was described. It was shown, that properly designed polyurethanes (PURs) find application in TE due to the proper physicochemical, mechanical and biological properties. Then the use of L-ascorbic acid (L-AA) in PUR systems for TE was described. L-AA has been applied in this area due to its suitable biological characteristics and antioxidative properties. Moreover, L-AA influences tissue regeneration due to improving collagen synthesis, which is a primary component of the extracellular matrix (ECM). Modification of PUR with L-AA leads to the materials with higher biocompatibility and such system is promising for TE applications.

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“…Morphological and pore size analysis was performed using a scanning electron microscope (SEM) (58)(59)(60). The samples were lyophilized, frozen in liquid nitrogen, fractured, coated with gold and observed using the Stereoscan-205 S SEM (Cambridge Instruments, Cambridge, MA).…”

Section: Pcl-calcium Alginate Spheres (Pcl-as) and Pcl-calcium Alginamentioning

confidence: 99%

Porous alginate/poly(ε-caprolactone) scaffolds: preparation, characterization and in vitro biological activity

Grandi

Liddo

Paganin³

et al. 2011

Int J Mol Med

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Abstract. In bone tissue engineering, scaffolds with controlled porosity are required to allow cell ingrowth, nutrient diffusion and sufficient formation of vascular networks. The physical properties of synthetic scaffolds are known to be dependent on the biomaterial type and its processing technique. In this study, we demonstrate that the separation phase technique is a useful method to process poly(Â-caprolactone) (PCL) into a desired shape and size. Moreover, using poly(ethylene glycol), sucrose, fructose and Ca 2+ alginate as porogen agents, we obtained PCL scaffolds with three-dimensional porous structures characterized by different pore size and geometry. Scanning electron microscopy and porosity analysis indicated that PCL scaffolds prepared with Ca 2+ alginate threads resemble the porosity and the homogeneous pore size distribution of native bone. In parallel, MicroCT analysis confirmed the presence of interconnected void spaces suitable to guarantee a biological environment for cellular growth, as demonstrated by a biocompatibility test with MC3T3-E1 murine preosteoblastic cells. In particular, scaffolds prepared with Ca 2+ alginate threads increased adhesion and proliferation of MC3T3-E1 cells under basal culture conditions, and upon stimulation with a specific differentiation culture medium they enhanced the early and later differentiated cell functions, including alkaline phosphatase activity and mineralized extracellular matrix production. These results suggest that PCL scaffolds, obtained by separation phase technique and prepared with alginate threads, could be considered as candidates for bone tissue engineering applications, possessing the required physical and biological properties.

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Fabrication and characterization of hydrophilic poly(lactic-co-glycolic acid)/poly(vinyl alcohol) blend cell scaffolds by melt-molding particulate-leaching method

Cited by 347 publications

References 43 publications

Preparation of interconnected poly(ε-caprolactone) porous scaffolds by a combination of polymer and salt particulate leaching

Preparation of interconnected poly(ε-caprolactone) porous scaffolds by a combination of polymer and salt particulate leaching

Ascorbic Acid in Polyurethane Systems for Tissue Engineering

Porous alginate/poly(ε-caprolactone) scaffolds: preparation, characterization and in vitro biological activity

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