Fabrication and characterization of gold nanoparticle-loaded TiO2 nanotube arrays for medical implants

Abstract

Au nanoparticles (AuNPs) are successfully assembled on TiO2 nanotube (TN) arrays through electrochemical deposition technology to improve the surface characteristics of TN arrays as an implant material. The loading amount of AuNPs can be controlled by adjusting the deposition time of electrochemical deposition. The effect of the amount of the loaded AuNPs on surface roughness and surface energy is systematically investigated on the basis of various characterizations. Results show that the increase in the loading amount of AuNPs on the TN arrays can increase surface roughness and decrease surface energy. Potentiodynamic polarization tests indicate that AuNP-modified TNs possess a higher corrosion resistance than unmodified TNs. Corrosion resistance increases as the amount of the loaded AuNP increases. In vitro cell culture tests are performed on the basis of cell morphology observations and MTT assays. Osteoblast cell adhesion and proliferation ability on the AuNP-modified TN surface are greater than those on the unmodified TN surface. The sample fabricated at the deposition time of 90 s exhibits an optimum cell performance. This work can provide a new platform to develop the surface chemistry of TN arrays and to fabricate titanium-based implant materials to enhance bioactivity.

Gold nanoparticle/nickel oxide/poly(pyrrole-N-propionic acid) hybrid multilayer film: Electrochemical study and its application in biosensing

“…The CV in the 5 th cycle exhibited two peaks: a reduction peak of Au 3+ and an oxidation peak of Au. The reduction peak potential of Au 3+ occurred at -0.48 V and the oxidation peak potential of Au at -0.09 V. The reduction peak current increased with an increase in the number of cycles due to the growth of the GNPs [44,45]. We deposited NiO onto the GNP-modified ITO electrode by performing a cathodic potential scan (-1.2 to 0.0 V) at an initial concentration of 10 mM Ni(NO 3 ) 2 .…”

The Influence of the Parameters of a Gold Nanoparticle Deposition Method on Titanium Dioxide Nanotubes, Their Electrochemical Response, and Protein Adsorption

“…3. Au 3+ near the titanium dioxide nanotube arrays can receive electrons and be reduced to Au, according to the Equation (4) [19]:…”

“…Therefore, Au 3+ ions move towards the polarized TNTs surface. As a consequence, more reduced Au crystals are formed on the surface of TNT arrays [19]. The AuNPs are homogeneously distributed on the surface of the TNT arrays.…”

“…The AuNPs are homogeneously distributed on the surface of the TNT arrays. Due to higher current densities, nucleation mostly takes place at the boundaries between titanium dioxide nanotubes ( Figure 1b-f)-places of the nanotubes contact [19,27]. Countless boundaries ( Figure 1a) provided many points of Au nanoparticles nucleation.…”

“…It is important to point out that the anodization must be under strictly defined conditions to avoid precipitation of the nanoparticles during TNT array growth [18]. In the chronoamperometric method, gold nanoparticles are not uniformly deposited on the TNT surfaces and can easily form agglomerates [19]. Due to its simplicity and its convenient control mechanisms in obtaining a homogeneous surface, the cyclic volt amperometric deposition method can be applied.…”