Fabrication and Characterization of Glycerol/Chitosan/Polyvinyl Alcohol-Based Transparent Hydrogel Films Loaded with Silver Nanoparticles for Antibacterial Wound Dressing Applications

Samadi, Ali; Azandeh, Saeed; Orazizadeh, Mahmoud; Bayati, Vahid; Rafienia, Mohammad; Karami, Masoud Ali

doi:10.4103/abr.abr_211_20

Cited by 16 publications

(8 citation statements)

References 24 publications

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“…These results are consistent with the gel fraction findings, suggesting a correlation between gel fraction and degradation rate, as expected. Samadi et al showed that the addition of npAg to a glycerol/chitosan/polyvinyl alcohol-based hydrogel significantly decreased the degradation rate [ 91 ], while Qui et al showed that an increase in npAg concentration in a hydroxypropyl methylcellulose-hydroxyapatite scaffold hydrogel leads to an increased degradation rate [ 105 ]. Wassenaar et al investigated how DOXY incorporation affects the degradation rate of an injectable hydrogel derived from decellularized porcine ventricular myocardium.…”

Section: Resultsmentioning

confidence: 99%

“…The microstructure of the hydrogel was assessed using SEM ( Figure 19 ). Increasing magnification and focus led to the destruction of the hydrogel’s surface in some cases, with the appearance of cracks, so the microscope parameters had to be carefully adjusted [ 91 ]. The surface morphology of the hydrogel membranes differs among formulations.…”

Section: Resultsmentioning

confidence: 99%

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Formulation and Comprehensive Evaluation of Biohybrid Hydrogel Membranes Containing Doxycycline or Silver Nanoparticles

Stan,

Ruta,

Bocancia-Mateescu

et al. 2023

Pharmaceutics

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Complicated wounds often require specialized medical treatments, and hydrogels have emerged as a popular choice for wound dressings in such cases due to their unique properties and the ability to incorporate and release therapeutic agents. Our focus was to develop and characterize a new optimized formula for biohybrid hydrogel membranes, which combine natural and synthetic polymers, bioactive natural compounds, like collagen and hyaluronic acid, and pharmacologically active substances (doxycycline or npAg). Dynamic (oscillatory) rheometry confirmed the strong gel-like properties of the obtained hydrogel membranes. Samples containing low-dose DOXY showed a swelling index of 285.68 ± 6.99%, a degradation rate of 71.6 ± 0.91% at 20 h, and achieved a cumulative drug release of approximately 90% at pH 7.4 and 80% at pH 8.3 within 12 h. The addition of npAg influenced the physical properties of the hydrogel membranes. Furthermore, the samples containing DOXY demonstrated exceptional antimicrobial efficacy against seven selected bacterial strains commonly associated with wound infections and complications. Biocompatibility assessments revealed that the samples exhibited over 80% cell viability. However, the addition of smaller-sized nanoparticles led to decreased cellular viability. The obtained biohybrid hydrogel membranes show favorable properties that render them suitable for application as wound dressings.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Formulation and Comprehensive Evaluation of Biohybrid Hydrogel Membranes Containing Doxycycline or Silver Nanoparticles

Stan,

Ruta,

Bocancia-Mateescu

et al. 2023

Pharmaceutics

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“…Next generation wound dressings should provide an occlusive wound bed, absorb exudate, and be conformable to the irregular topography of the stratum corneum, while also being transparent to allow for easy inspection by clinicians without removal of the bandage. Additionally, these wound dressings should be cost efficient and avoid the use of relatively expensive doping agents such as silver nanoparticles [13] , dextran [14] and/or chitosan [11] . The biocompatibility, ease of fabrication, cost, absorbing capabilities, and scalability render PVA a promising material for use in a wide array of applications including but limited to scaffold materials [15] , doped hydrogels [16] for pharmaceutical applications [17] , sacrificial layer in fabricating epidermal electronics [18] and as a stand-alone or composite material for wound dressings [11] , [19] – [21] .…”

Section: Introductionmentioning

confidence: 99%

“…The biocompatibility, ease of fabrication, cost, absorbing capabilities, and scalability render PVA a promising material for use in a wide array of applications including but limited to scaffold materials [15] , doped hydrogels [16] for pharmaceutical applications [17] , sacrificial layer in fabricating epidermal electronics [18] and as a stand-alone or composite material for wound dressings [11] , [19] – [21] . There is a paucity of commercial controls utilized within studies of PVA based wound dressings to provide clinical relevance [13] , [19] , [22] , [23] . Elucidating the mechanical and absorption properties of PVA based on varied glycerol concentrations for the fabrication of a wound dressing has not previously been studied.…”

Section: Introductionmentioning

confidence: 99%

An Absorbent, Flexible, Transparent, and Scalable Substrate for Wound Dressings

Seshadri

Bianco

Radwan

et al. 2022

IEEE J. Transl. Eng. Health Med.

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Objective: Wound dressings that create and maintain a moist environment provide the optimal conditions for wound healing by increasing the rate of epithelialization and angiogenesis. However, current wound dressings require periodic removal which exposes the wound to the surrounding environment, thereby increasing the likelihood for infection and drying out the wound itself. There remains an unmet medical need for the development of an absorbent, flexible, and transparent wound dressing that can conform to the irregular geometry of the wound for a long-term duration. Herein, we report the development of AFTI Derm, an Absorbent, Flexible, Transparent, and Inexpensive moisture-management wound dressing using Polyvinyl alcohol (PVA) as the host material. Methods: AFTI Derm substrates of varying glycerol concentrations (1 wt%, 3 wt%, 5 wt%, 7 wt%, and 10 wt%) were fabricated and tested. The mechanical, absorption, and biological properties of AFTI Derm were evaluated. Results: We found that 5% glycerol served as the optimal concentration for AFTI Derm. The biocompatibility, absorptive capabilities, and scalability render PVA/glycerol an ideal material composition for wound dressings. Benchtop experimentation and pre-clinical testing demonstrate AFTI Derm as a platform for use in wound dressings. Discussion/Conclusion: The development of AFTI Derm broadens the translational utility of this materials platform not only as a material for wound dressings to minimize dressing changes in low to moderate exudate environments, but also as a potential substrate material for smart bandages. Clinical and Translational Impact Statement— AFTI Derm, an absorbent, flexible, and transparent wound dressing, maintains the moist environment required for healing while enabling monitoring of healing without removal and disruption to the wound bed.

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“…The disadvantage of these traditional antimicrobial agents is related to antibiotic resistance. The alternative to topical antimicrobial agents is to develop new wound healing materials based on alginate [17], chitosan [6,18], collagen [19], nanocellulose [20], inorganic antimicrobial agents such as zinc oxide [5,21], and plant extracts [22].…”

Section: Introductionmentioning

confidence: 99%

Bioactive Collagen Hydrolysate-Chitosan/Essential Oil Electrospun Nanofibers Designed for Medical Wound Dressings

et al. 2021

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In this study, lemon balm (Melissa officinalis L.) and dill (Anethum graveolens L.) essential oils (EOs) were encapsulated into collagen hydrolysates extracted from bovine tendons and rabbit skins, both mixed with chitosan (CS) by using the coaxial electrospinning technique for potential wound dressing applications. The morphology and chemical composition of the electrospun nanofibers were investigated using scanning electron microscopy (SEM) and attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR). The antimicrobial activity of the dill EO and lemon EO, as well as the electrospun samples loaded with essential oils was determined by disk diffusion assay against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Enterococcus faecalis ATCC 29212, and Salmonella typhimurium ATCC 14028 bacterial strains; Candida albicans ATCC 10231 and Candida glabrata ATCC 90028 yeast strains; and Aspergillus brasiliensis ATCC 9642 fungal strain. In vivo biocompatibility testing of the collagen hydrolysate-chitosan/essential oil electrospun nanofibers was based on the determination of the hematological, biochemical, and immunological profile and the evaluation of the influence produced on the oxidative stress in white Swiss mice. The synergetic effect of dill and lemon balm EOs can improve the antimicrobial activity of collagen hydrolysate-chitosan nanofibers against the most important bacterial strains. The in vivo test results suggested a good biocompatibility of electrospun samples based on collagen hydrolysate extracted from bovine tendons or rabbit skin mixed with chitosan and containing dill and/or lemon balm essential oils as encapsulated bioactive compounds.

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Fabrication and Characterization of Glycerol/Chitosan/Polyvinyl Alcohol-Based Transparent Hydrogel Films Loaded with Silver Nanoparticles for Antibacterial Wound Dressing Applications

Cited by 16 publications

References 24 publications

Formulation and Comprehensive Evaluation of Biohybrid Hydrogel Membranes Containing Doxycycline or Silver Nanoparticles

Formulation and Comprehensive Evaluation of Biohybrid Hydrogel Membranes Containing Doxycycline or Silver Nanoparticles

An Absorbent, Flexible, Transparent, and Scalable Substrate for Wound Dressings

Bioactive Collagen Hydrolysate-Chitosan/Essential Oil Electrospun Nanofibers Designed for Medical Wound Dressings

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