Fabrication and characterization of dual acting oleyl chitosan functionalised iron oxide/gold hybrid nanoparticles for MRI and CT imaging

Hemalatha, Thiagarajan; Prabu, P.; Gunadharini, Dharmalingam Nandagopal; Gowthaman, M.K.

doi:10.1016/j.ijbiomac.2018.01.159

Cited by 31 publications

(13 citation statements)

References 28 publications

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“…AuNPs were used as a contrast agent and imaged using a clinical CT scanner where the images reflected the X-ray attenuation potency of the nanocomposite in a dose dependent manner. 145…”

Section: Gold Nanoparticles In Sensingmentioning

confidence: 99%

<p>Recent Developments in the Facile Bio-Synthesis of Gold Nanoparticles (AuNPs) and Their Biomedical Applications</p>

Lee

Shameli

Yew

et al. 2020

IJN

305

142

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Gold nanoparticles (AuNPs) are extensively studied nanoparticles (NPs) and are known to have profound applications in medicine. There are various methods to synthesize AuNPs which are generally categorized into two main types: chemical and physical synthesis. Continuous efforts have been devoted to search for other more environmental-friendly and economical large-scale methods, such as environmentally friendly biological methods known as green synthesis. Green synthesis is especially important to minimize the harmful chemical and toxic by-products during the conventional synthesis of AuNPs. Green materials such as plants, fungi, microorganisms, enzymes and biopolymers are currently used to synthesize various NPs. Biosynthesized AuNPs are generally safer for use in biomedical applications since they come from natural materials themselves. Multiple surface functionalities of AuNPs allow them to be more robust and flexible when combined with different biological assemblies or modifications for enhanced applications. This review focuses on recent developments of green synthesized AuNPs and discusses their numerous biomedical applications. Sources of green materials with successful examples and other key parameters that determine the functionalities of AuNPs are also discussed in this review.

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“…AuNPs were used as a contrast agent and imaged using a clinical CT scanner where the images reflected the X-ray attenuation potency of the nanocomposite in a dose dependent manner. 145…”

Section: Gold Nanoparticles In Sensingmentioning

confidence: 99%

<p>Recent Developments in the Facile Bio-Synthesis of Gold Nanoparticles (AuNPs) and Their Biomedical Applications</p>

Lee

Shameli

Yew

et al. 2020

IJN

305

142

View full text Add to dashboard Cite

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“…For instance, oleyl chitosan-coated iron oxide nanoparticles were recommended as a dual probe for optical and magnetic resonance imaging of tumours [ 107 ]. In a recent report, Hemalatha et al [ 158 ] showed that oleyl chitosan was a suitable platform for inorganic nanoparticle encapsulation (namely hybrid iron oxide/gold nanostructures) that guaranteed both high colloidal stability and better magnetic resonance imaging. At the same time, the magnetic nanocomposite exhibited good appropriate characteristics for computer tomography: biocompatibility, X-ray attenuation properties and hemocompatibility.…”

Section: Surface Shell Engineering Of Magnetic Materials For Imaging Purposesmentioning

confidence: 99%

Imaging Constructs: The Rise of Iron Oxide Nanoparticles

et al. 2021

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Over the last decade, an important challenge in nanomedicine imaging has been the work to design multifunctional agents that can be detected by single and/or multimodal techniques. Among the broad spectrum of nanoscale materials being investigated for imaging use, iron oxide nanoparticles have gained significant attention due to their intrinsic magnetic properties, low toxicity, large magnetic moments, superparamagnetic behaviour and large surface area—the latter being a particular advantage in its conjunction with specific moieties, dye molecules, and imaging probes. Tracers-based nanoparticles are promising candidates, since they combine synergistic advantages for non-invasive, highly sensitive, high-resolution, and quantitative imaging on different modalities. This study represents an overview of current advancements in magnetic materials with clinical potential that will hopefully provide an effective system for diagnosis in the near future. Further exploration is still needed to reveal their potential as promising candidates from simple functionalization of metal oxide nanomaterials up to medical imaging.

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“…Iron oxide nanoparticles have been used to deliver anti-cancer drugs like 5-flurouracil [22], cisplatin [23], camptothecin [24], doxorubicin [25], methotrexate [26], tamoxifen [27], paclitaxel [28], sorafenib [29], gemcitabine [30], 6-mercaptopurine [31] and mitoxantrone [32] to the target tissue. These nanoparticles have also been used along with other carriers such as gold [33], chitosan [34], silica [35], carbon nanotubes [36], surfactant [37], C 60 [38], peptide nanotubes [39],lipid [40], liposome [41], dextran [42], polymers [43,44] and DNA [45].…”

Section: Introductionmentioning

confidence: 99%

A quantum chemical study on the magnetic nanocarrier-tirapazamine drug delivery system

Avarand¹,

Morsali²,

Heravi³

et al. 2021

Nanosystems: Phys. Chem. Math.

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Magnetic nanoparticles are among the most important carriers for the delivery of anticancer drugs. Four important noncovalent interactions between tirapazamine anticancer drug (TPZ) and magnetic nanoparticle Fe 6 (OH) 18 (H 2 O) 6 (MNP) have been examined by using density functional theory (DFT). Important interactions are those where the drug approaches the magnetic nanocarrier via NH 2 (MNP/TPZ1), NO (MNP/TPZ2-3) and intraring N-atom (MNP/TP4) functional groups. The negative values of binding energies and quantum molecular descriptor showed that these interactions contribute to the stability of the system. By increasing the temperature, TPZ can bond to MNP through NH 2 (NH 2 mechanism), NO (NO mechanisms) and intraring N-atom (N mechanism) functional groups. The activation parameters of four mechanisms were evaluated using quadratic synchronous transit method. Relative energies indicate that the product of the NH 2 mechanism is more stable but is produced more slowly (thermodynamic product). In contrast, the products of the NO mechanisms are kinetic products.

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Fabrication and characterization of dual acting oleyl chitosan functionalised iron oxide/gold hybrid nanoparticles for MRI and CT imaging

Cited by 31 publications

References 28 publications

<p>Recent Developments in the Facile Bio-Synthesis of Gold Nanoparticles (AuNPs) and Their Biomedical Applications</p>

<p>Recent Developments in the Facile Bio-Synthesis of Gold Nanoparticles (AuNPs) and Their Biomedical Applications</p>

Imaging Constructs: The Rise of Iron Oxide Nanoparticles

A quantum chemical study on the magnetic nanocarrier-tirapazamine drug delivery system

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