Fabrication and characterization of dissolving microneedle arrays for improving skin permeability of cosmetic ingredients

Park, Yong-Hun; Kim, Kyu Sik; Chung, Minsub; Sung, Jong Hwan; Kim, Bumsang

doi:10.1016/j.jiec.2016.05.022

Cited by 28 publications

(15 citation statements)

References 21 publications

(21 reference statements)

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“…Incorporating different molecular weights of the same polymer or other components can tailor the dissolution profile. Hence, dissolution matrices amenable for prolonged DD can also be fabricated [168]. Dissolvable MNs are poised to provide a beneficial route to the administration of biopharmaceuticals in the lowermicrogram range, in smaller doses than those administered using injections, reducing not only the systemic effects but also the treatment costs [169].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…In fact, polysaccharides like HA [182][183][184][185] , CS [186][187][188], and dextran [189] , among others [67,190] . have been used alone or combined with other biopolymers such as amylopectin [153,154,160,168,191] to engineer MNs for the delivery of drugs such as doxorubicin [192] and lidocaine [193], biopharmaceuticals such as insulin [175,194,195] or vaccines [196], and also natural extracts. The next sections give an overview of polysaccharides used in MNs.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…In a different perspective, to decrease the dissolution rate and increase the mechanical strength of HA microneedles, Park et al [168] introduced amylopectin into a MNs system designed to deliver model cosmetic ingredients, namely niacin and ascorbic acid. In this study, the mechanical strength of the MNs increased with increasing amounts of amylopectin added up to a ratio of 1:2.3 (HA:amylopectin).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

See 2 more Smart Citations

A compendium of current developments on polysaccharide and protein-based microneedles

Fonseca

Vilela

Silvestre

et al. 2019

International Journal of Biological Macromolecules

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Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

See 1 more Smart Citation

A compendium of current developments on polysaccharide and protein-based microneedles

Fonseca

Vilela

Silvestre

et al. 2019

International Journal of Biological Macromolecules

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“…Therefore, dissolving microneedles (DMNs), drug-encapsulated dissolvable microscalepolymeric needles, were investigated to eliminate the safety issues that emerge after SMNs application. DMNs have been designed to penetrate skin barriers and release drugs into perforated skin channels after dissolution by body fluid in the skin [23,24]. To ensure user safety, DMNs are fabricated using biocompatible and degradable FDA-approved polymers, such as polyvinyl pyrrolidone, carboxymethyl cellulose, and hyaluronic acid, which have been extensively researched for cosmetic and medical treatments [25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

“…To ensure user safety, DMNs are fabricated using biocompatible and degradable FDA-approved polymers, such as polyvinyl pyrrolidone, carboxymethyl cellulose, and hyaluronic acid, which have been extensively researched for cosmetic and medical treatments [25][26][27][28][29]. Indeed, DMNs encapsulating niacinamide and ascorbic acid significantly increased the delivery of niacinamide to the skin and the antioxidant activity of ascorbic acid in the skin [24]. In addition, the application of DMNs encapsulating adenosine, which is known to improve skin wrinkles, showed improved cosmetic effects compared with the topical application of adenosine cream [25].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Micro-Channeling System via Dissolving Microneedle to Improve Transdermal Serum Delivery for Various Clinical Skincare Treatments

et al. 2022

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Topical liquid formulations, dissolving microneedles (DMNs), and microscale needles composed of biodegradable materials have been widely used for the transdermal delivery of active compounds for skincare. However, transdermal active compound delivery by topical liquid formulation application is inhibited by skin barriers, and the skincare efficacy of DMNs is restricted by the low encapsulation capacity and incomplete insertion. In this study, topical serum application via a dissolvable micro-channeling system (DMCS) was used to enhance serum delivery through micro-channels embedded with DMNs. Transdermal serum delivery was evaluated after the topical-serum-only application and combinatorial serum application by assessing the intensity of allophycocyanin (APC) loaded with the serum in the porcine skin. APC intensity was significantly higher in the skin layer at a depth of 120–270 μm upon combinatorial serum application as compared to topical-serum-only application. In addition, the combinatorial serum application showed significantly improved efficacy in the clinical assessment of skin hydration, depigmentation, improvement of wrinkles, elasticity, dermal density, skin pores, and skin soothing without any safety issues compared to the serum-only application. The results indicate that combinatorial serum application with DMCS is a promising candidate for improving skincare treatments with optimal transdermal delivery of active compounds.

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A systematic review of carbohydrate-based microneedles: current status and future prospects

Bhadale

Londhe

2021

J Mater Sci: Mater Med

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Microneedles (MNs) are minimally invasive tridimensional biomedical devices that bypass the skin barrier resulting in systemic and localized pharmacological effects. Historically, biomaterials such as carbohydrates, due to their physicochemical properties, have been used widely to fabricate MNs. Owing to their broad spectrum of functional groups, carbohydrates permit designing and engineering with tunable properties and functionalities. This has led the carbohydrate-based microarrays possessing the great potential to take a futuristic step in detecting, drug delivery, and retorting to biologicals. In this review, the crucial and extensive summary of carbohydrates such as hyaluronic acid, chitin, chitosan, chondroitin sulfate, cellulose, and starch has been discussed systematically, using PRISMA guidelines. It also discusses different approaches for drug delivery and the mechanical properties of biomaterial-based MNs, till date, progress has been achieved in clinical translation of carbohydrate-based MNs, and regulatory requirements for their commercialization. In conclusion, it describes a brief perspective on the future prospects of carbohydrate-based MNs referred to as the new class of topical drug delivery systems.

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Fabrication and characterization of dissolving microneedle arrays for improving skin permeability of cosmetic ingredients

Cited by 28 publications

References 21 publications

A compendium of current developments on polysaccharide and protein-based microneedles

A compendium of current developments on polysaccharide and protein-based microneedles

Enhanced Micro-Channeling System via Dissolving Microneedle to Improve Transdermal Serum Delivery for Various Clinical Skincare Treatments

A systematic review of carbohydrate-based microneedles: current status and future prospects

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