Fabrication and characterization of dihydromyricetin encapsulated zein-caseinate nanoparticles and its bioavailability in rat

Sun, Cuicui; Su, Hang; Zheng, Guodong; Wang, Wenjun; Yuan, Erdong; Zhang, Qingfeng

doi:10.1016/j.foodchem.2020.127245

Cited by 43 publications

(22 citation statements)

References 38 publications

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“…Source Biological Activity Quercetin Red grapes circulation system protection, anti-allergic, anti-inflammatory, anti-cancer, anti-diabetes, cataract prevention, cardiovascular protection, anti-ulcer, anti-diabetes [13][14][15] Luteolin anti-inflammatory, neuroprotective, anti-cancer [10,16,17] Dihydromyricetin anti-cancer, anti-inflammatory, anti-microbial, hepatoprotective, lipid and glucose metabolism regulation [18,19] Apigenin Scutellaria baicalensis Georgi vasorelaxant effects, decrease in heart pressure, dose-dependent lowering concentrations of low-density lipoprotein cholesterol, triglycerides and total content of cholesterol in their serum, anti-inflammatory [8,20,21] Chrysin anti-inflammatory, antihypertensive activity, neuroprotective, anticancer properties, possessed protective effects against toxic agents [8,22,23] Baicalein anti-viral, neuroprotective and enhancing cognitive functions, anti-inflammatory, anticancer, hepatoprotection, anti-hypertensive, cardioprotective, antiplatelet, anticoagulant, and profibrinolytic activities [8,24,25].…”

Section: Compoundsmentioning

confidence: 99%

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Antioxidant and Antiradical Properties of Some Examples of Flavonoids and Coumarins—Potentiometric Studies

et al. 2021

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A comprehensive study of a range of flavonoids and coumarins is presented in this article. The work uses an approach that evaluates the activity of these compounds by various mechanisms: the electron transfer (ET), the hydrogen atom transfer (HAT), and the mechanism of metal chelation. The studies were carried out using the methods of the cyclic voltammetry and the potentiometry. The electrochemical behavior of these compounds was studied by the method of cyclic voltammetry; the main types of voltammograms, depending on the oxidation mechanisms, were identified. Various versions of potentiometric sensor systems have been used to detect analytical signal in approaches implemented in ET, HAT and metal chelation mechanisms. The antioxidant capacity was studied by the electron-transfer mechanism. Compounds with antioxidant properties were selected; half-reaction periods for these compounds have been determined. It has been shown that electron-donating and complexing properties directly depend on the mutual arrangement of hydroxyl groups in the molecule. The antiradical ability of the compounds has been studied. It was shown that all studied compounds inhibit peroxyl radicals. Series on the change in antioxidant and antiradical properties of compounds have been compiled. There is no correlation between the results of the study of antioxidant properties obtained using sensory systems that reveal various antioxidant mechanisms. The need to use an integrated approach in the study of antioxidant properties is shown.

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Section: Compoundsmentioning

confidence: 99%

“…anti-carcinogenic effects, nephroprotective activity against kidney injury induced by cisplatin and its hepatoprotective activity against "nonalcoholic fatty liver disease", antiinflammatory activity [26][27][28] anti-cancer, anti-inflammatory, anti-microbial, hepatoprotective, lipid and glucose metabolism regulation [18,19] Apigenin…”

Section: Genista Tinctorialmentioning

confidence: 99%

Antioxidant and Antiradical Properties of Some Examples of Flavonoids and Coumarins—Potentiometric Studies

et al. 2021

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“…Zein has been extensively investigated for the encapsulation of bioactive compounds (e.g. vitamin D3, resveratrol, quercetin and antimicrobials) [12][13][14][15][16] because of its easy self-assembly into NPs, and sustained drug release capability. 17 However, zein nanoparticles have poor physical stability at neutral pH or high salinity, and poor redispersibility after centrifugation or lyophilization.…”

Section: Introductionmentioning

confidence: 99%

Development of curcumin-loaded zein nanoparticles for transport across the blood–brain barrier and inhibition of glioblastoma cell growth

Zhang

Tian

et al. 2021

Biomater. Sci.

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“…However, metabolites of DMY were not detected in plasma [66]. Whereas, Sun et al identified 5 metabolites of DMY in rat plasma by UPLC-QTOF-MS, including DMY sulfate (DMY-Sul), DMY glucuronide (DMY-Glu), methylated DMY (DMY-Methyl), methylated DMY glucuronide (DMY-Methyl-Glu) and methylated DMY sulfate (DMY-Methyl-Sul) [72] . We hypothesized that Fan et al did not detect metabolites of DMY in plasma because of their instability, low content, or improper pretreatment methods.…”

Section: Metabolites Of Dmy In Urine Feces and Plasmamentioning

confidence: 99%

“…DZP significantly improved the diffusion rate of DMY in SGF and SIF and the stability of DMY in SIF. Moreover, DZP exhibited a 1.95‐fold increase in the oral bioavailability along with the enhanced DMY metabolites level in plasma [72].…”

Section: Approaches To Improve the Stability And Bioavailability Of Dmymentioning

confidence: 99%

A multifaceted review on dihydromyricetin resources, extraction, bioavailability, biotransformation, bioactivities, and food applications with future perspectives to maximize its value

Zhang

Caprioli²,

Hussain

et al. 2021

eFood

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Natural bioactive compounds present a better alternative to prevent and treat chronic diseases owing to their lower toxicity and abundant resources. (+)-Dihydromyricetin (DMY) is a flavanonol, possessing numerous interesting bioactivities with abundant resources. This review provides a comprehensive overview of the recent advances in DMY natural resources, stereoisomerism, physicochemical properties, extraction, biosynthesis, pharmacokinetics, and biotransformation. Stereoisomerism of DMY should be considered for better indication of its efficacy. Biotechnological approach presents a potential tool for the production of DMY using microbial cell factories. DMY high instability is related to its powerful antioxidant capacity due to pyrogallol moiety in ring B, and whether preparation of other analogues could demonstrate improved properties. DMY demonstrates poor bioavailability based on its low solubility and permeability with several attempts to improve its pharmacokinetics and efficacy. DMY possesses various pharmacological effects, which have been proven by many in vitro and in vivo experiments, while clinical trials are rather scarce, with underlying action mechanisms remaining unclear. Consequently, to maximize the usefulness of DMY in nutraceuticals, improvement in bioavailability, and better understanding of its actions mechanisms and drug interactions ought to be examined in the future along with more clinical evidence.

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Fabrication and characterization of dihydromyricetin encapsulated zein-caseinate nanoparticles and its bioavailability in rat

Cited by 43 publications

References 38 publications

Antioxidant and Antiradical Properties of Some Examples of Flavonoids and Coumarins—Potentiometric Studies

Antioxidant and Antiradical Properties of Some Examples of Flavonoids and Coumarins—Potentiometric Studies

Development of curcumin-loaded zein nanoparticles for transport across the blood–brain barrier and inhibition of glioblastoma cell growth

A multifaceted review on dihydromyricetin resources, extraction, bioavailability, biotransformation, bioactivities, and food applications with future perspectives to maximize its value

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