Fabrication and characterization of chitosan conjugated eurycomanone nanoparticles: In vivo evaluation of the biodistribution and toxicity in fish

Bhat, Irfan Ahmad; Nazir, Mir Ishfaq; Ahmad, Irshad; Gireesh‐Babu, P.; Chanu, Thongam Ibemcha; Goswami, Mukunda; Sundaray, Jitendra Kumar; Sharma, Rupam

doi:10.1016/j.ijbiomac.2018.02.067

Cited by 22 publications

(12 citation statements)

References 54 publications

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“…Our results are in tune with other reported biodistribution patterns where different types of nanoparticles, including carbon nanotubes [ 47 ], self-assembling bacterial nanotoxins [ 12 ] or chitosan, lipidoid and latex nanoparticles [ 14 , 15 , 48 ], were similarly labeled with small molecular weight fluorescent dyes such as Rhodamines, Cyanines or ATTO molecules for in vivo tracking purposes. In all these experiments, strong liver or kidney accumulation was observed upon in vivo administration.…”

Section: Discussionsupporting

confidence: 90%

Fluorescent Dye Labeling Changes the Biodistribution of Tumor-Targeted Nanoparticles

et al. 2020

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Fluorescent dye labeling is a common strategy to analyze the fate of administered nanoparticles in living organisms. However, to which extent the labeling processes can alter the original nanoparticle biodistribution has been so far neglected. In this work, two widely used fluorescent dye molecules, namely, ATTO488 (ATTO) and Sulfo-Cy5 (S-Cy5), have been covalently attached to a well-characterized CXCR4-targeted self-assembling protein nanoparticle (known as T22-GFP-H6). The biodistribution of labeled T22-GFP-H6-ATTO and T22-GFP-H6-S-Cy5 nanoparticles has been then compared to that of the non-labeled nanoparticle in different CXCR4+ tumor mouse models. We observed that while parental T22-GFP-H6 nanoparticles accumulated mostly and specifically in CXCR4+ tumor cells, labeled T22-GFP-H6-ATTO and T22-GFP-H6-S-Cy5 nanoparticles showed a dramatic change in the biodistribution pattern, accumulating in non-target organs such as liver or kidney while reducing tumor targeting capacity. Therefore, the use of such labeling molecules should be avoided in target and non-target tissue uptake studies during the design and development of targeted nanoscale drug delivery systems, since their effect over the fate of the nanomaterial can lead to considerable miss-interpretations of the actual nanoparticle biodistribution.

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Section: Discussionsupporting

confidence: 90%

Fluorescent Dye Labeling Changes the Biodistribution of Tumor-Targeted Nanoparticles

et al. 2020

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“…These toxicities may hinder the development of the natural product as an anticancer drug, unless the active doses are carefully defined and/or the drug is properly formulated to protect the GI‐tract. Specific formulations have been developed for such highly polar quassinoids, using for examples a lipid‐based solid dispersion (Ma, Ebrahimi, Low, Khan, & Chan, 2017) or a chitosan‐conjugated nanoformulation (Bhat et al, 2018). Alternatively, new derivatives could be designed, such as SUN2071 (Kato et al, 1988) but the chemistry and structure–activity relationships are complex (Z. Li et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Anticancer properties and mechanism of action of the quassinoid ailanthone

Bailly

2020

Phytotherapy Research

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Ailanthone (AIT) is a quassinoid natural product isolated from the worldwide‐distributed plant Ailanthus altissima. The drug displays multiple pharmacological properties, in particular significant antitumor effects against a variety of cancer cell lines in vitro. Potent in vivo activities have been evidenced in mice bearing hepatocellular carcinoma, nonsmall cell lung cancer and castration‐resistant prostate cancer. This review focusses on the mechanism of action of AIT, notably to highlight the capacity of the drug to activate DNA damage responses, to inhibit the Hsp90 co‐chaperone p23 and to modulate the expression of several microRNA. The interconnexion between these effects is discussed. The unique capacity of AIT to downregulate oncogenic miR‐21 and to upregulate the tumor suppressor miRNAs miR‐126, miR‐148a, miR‐195, and miR‐449a is presented. AIT exploits several microRNAs to exert its anticancer effects in distinct tumor types. AIT is one of the rare antitumor natural products that binds to and strongly inhibits cochaperone p23, opening interesting perspectives to treat cancers. However, the toxicity profile of the molecule may limit its development as an anticancer drug, unless it can be properly formulated to prevent AIT‐induced gastro‐intestinal damages in particular. The antitumor properties of AIT and analogs are underlined, with the aim to encourage further pharmacological studies with this underexplored natural product and related quassinoids. Highlights Ailanthone (AIT) is an anticancer quassinoid isolated from Ailanthus altissima It inhibits proliferation and induces cell death of many cancer cell types The drug activates DNA damage response and targets p23 cochaperone Up or downregulation of several microRNA by AIT contributes to the anticancer activity Analogs or specific formulations must be developed to prevent the toxicity of AIT

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“…In the synthesis of chitosan conjugates, in addition to the above synthesis methods, other methods have also been reported in the literature. Examples include the Maillard reaction [106], acid-base salt formation reaction [36], and electrochemical reaction [107]. For instance, the Maillard reaction is commonly used for the coupling of xylan [108], polylysine [109], and lysozyme [47,106,110] with chitosan.…”

Section: Other Methodsmentioning

confidence: 99%

“…Sometimes, a solubilizing moiety or linker is needed. Based on this conjugation strategy, active ingredients such as caffeic acid [31], ferulic acid [32], tannic acid [33], catechin [34], curcumin [35], eurycomanone [36], streptomycin [37], gibberellin [38], cysteine [39], lysozyme [40], levofloxacin [41], cefuroxime [42] were reported to succeed in coupling with chitosan.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Chitosan Conjugates: Current Synthetic Strategies and Potential Applications

Qin

2020

IJMS

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As a natural polysaccharide, chitosan possesses good biocompatibility, biodegradability and biosafety. Its hydroxyl and amino groups make it an ideal carrier material in the construction of polymer-drug conjugates. In recent years, various synthetic strategies have been used to couple chitosan with active substances to obtain conjugates with diverse structures and unique functions. In particular, chitosan conjugates with antimicrobial activity have shown great application prospects in the fields of medicine, food, and agriculture in recent years. Hence, we will place substantial emphasis on the synthetic approaches for preparing chitosan conjugates and their antimicrobial applications, which are not well summarized. Meanwhile, the challenges, limitations, and prospects of antimicrobial chitosan conjugates are described and discussed.

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Fabrication and characterization of chitosan conjugated eurycomanone nanoparticles: In vivo evaluation of the biodistribution and toxicity in fish

Cited by 22 publications

References 54 publications

Fluorescent Dye Labeling Changes the Biodistribution of Tumor-Targeted Nanoparticles

Fluorescent Dye Labeling Changes the Biodistribution of Tumor-Targeted Nanoparticles

Anticancer properties and mechanism of action of the quassinoid ailanthone

Antimicrobial Chitosan Conjugates: Current Synthetic Strategies and Potential Applications

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