Fabrication and characterization of ceramic-polymer composite 3D scaffolds and demonstration of osteoinductive propensity with gingival mesenchymal stem cells

Abstract

The fabrication and characterization of CP/Col-I composite scaffolds and the demonstration of their promising potential in osteoinduction and bone tissue engineering.

Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications

“…MicroCT scanning and scanning electron microscopy confirmed the successful preparation of the HA/collagen scaffolds composed of fully assembled microscopic fibers, while the mechanical properties of the scaffolds were double-reinforced by many newborn HA nanoparticles and chemical bonds [753]. Freeze-drying can be used as well [754]. More complex biocomposites, such as magnetiteenriched HA/collagen [755], HA/osteocalcin/collagen [487], HA/collagen/PLA [603][604][605][606][607], HA/collagen/alginic acid [609,610], HA/collagen/PVA [608,756], HA/collagen/chitosan [757], HA/collagen/acidic gelatin/basic fibroblast growth factor (b-FGF) [758], and calcium silicate/β-TCP/collagen [759], have also been developed.…”

“…Traditionally, collagen/CaPO 4 biocomposites have been produced by blending or mixing CaPO 4 with collagen by means of various techniques, as well as by biomimetic precipitation [594,602,604,692,[714][715][716][717][718]727,738,[742][743][744][745][746][747][748][749][750][751][752][753][754]. For example, apatite/collagen bone-like biocomposites were prepared by two different methodologies: (1) dispersion of apatite in collagen aqueous suspension followed by lyophilization and (2) direct nucleation of the apatite phase on collagen fiber aggregates [716].…”

Pro-angiogenic and antibacterial copper containing nanoparticles in PLGA/amorphous calcium phosphate bone nanocomposites

“…Many material-related approaches exist to fabricate bone substitutes, including ceramics [ 3 ], polymers [ 4 ] and composite materials [ 5 ]. Besides 3D printing [ 6 ], electrospinning techniques are considered in BTE [ 7 ].…”