Fabrication and characterization of budesonide loaded colon-specific nanofiber drug delivery systems using anionic and cationic polymethacrylate polymers

Turanlı, Yasin; Acartürk, Füsun

doi:10.1016/j.jddst.2021.102511

Cited by 16 publications

(13 citation statements)

References 60 publications

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“…Chitosan is a semi-crystalline polymeric material with two characteristic peaks at 2θ of 11 and 21 [ 80 ]. The characteristic peaks of BU appeared at 2θ of 5.99, 11.95, 14.42, 15.36 and 15.96 which confirmed the crystalline nature of the drug have also been reported elsewhere [ 28 ]. The XRPD spectra of BCN exhibited the characteristic peak of BU with reduced intensity confirming the reduced crystallinity of the drug in nanoparticles.…”

Section: Resultssupporting

confidence: 86%

“…Amongst the methods mentioned above, the design of a pH-sensitive nano-delivery system is one of the simplest [ 24 ] and most commonly used approaches for the selective delivery of nanoparticles to the site of inflammation [ 6 , 25 , 26 ]. Many studies demonstrated that pH-dependent BU nanoparticles could alleviate the colitis better than plain nanoparticles [ 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

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Preparation and Characterization of a Novel Multiparticulate Dosage Form Carrying Budesonide-Loaded Chitosan Nanoparticles to Enhance the Efficiency of Pellets in the Colon

et al. 2022

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An attempt was made to conquer the limitation of orally administered nanoparticles for the delivery of budesonide to the colon. The ionic gelation technique was used to load budesonide on chitosan nanoparticles. The nanoparticles were investigated in terms of size, zeta potential, encapsulation efficiency, shape and drug release. Then, nanoparticles were pelletized using the extrusion–spheronization method and were investigated for their size, mechanical properties, and drug release. Pellets were subsequently coated with a polymeric solution composed of two enteric (eudragit L and S) and time-dependent polymers (eudragit RS) for colon-specific delivery. All formulations were examined for their anti-inflammatory effect in rats with induced colitis and the relapse of the colitis after discontinuation of treatment was also followed. The size of nanoparticles ranged between 288 ± 7.5 and 566 ± 7.7 nm and zeta potential verified their positive charged surface. The drug release from nanoparticles showed an initial burst release followed by a continuous release. Pelletized nanoparticles showed proper mechanical properties and faster drug release in acidic pH compared with alkaline pH. It was interesting to note that pelletized budesonide nanoparticles released the drug throughout the GIT in a sustained fashion, and had long-lasting anti-inflammatory effects while rapid relapse was observed for those treated with conventional budesonide pellets. It seems that there is a synergistic effect of nanoformulation of budesonide and the encapsulation of pelletized nanoparticles in a proper coating system for colon delivery that could result in a significant and long-lasting anti-inflammatory effect.

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Section: Resultssupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of a Novel Multiparticulate Dosage Form Carrying Budesonide-Loaded Chitosan Nanoparticles to Enhance the Efficiency of Pellets in the Colon

et al. 2022

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“…The use of time-dependent polymers (Eudragit ® NM) and pH-dependent polymers (Eudragit ® FS) and the use of combinations of Eudragit ® time- and pH-dependent polymers have been used in different works to improve colonic release [ 43 , 44 ]. Moreover, the absence of burst effects in the different Metocel ® /Eudragit ® granule justifies the efficient interpenetration of MLX within the network [ 45 ].…”

Section: Resultsmentioning

confidence: 99%

“…The Korsmeyer-Peppas kinetic model exhibits anomalous (non-Fickian) dissolution with n values ranging from 0.60 to 0.82, for most formulations excepting NM + FS, NM and CFS, suggesting that the rate of water uptake into the matrix of granules and MLX release were controlled by diffusion through the system structure and dissolution and swelling/erosion processes [ 48 ]. The absence of burst effects in both, CNM and CNM + CFS granules, justified the efficient interpenetration of MLX within the network [ 45 ]. According to the Korsmeyer–Peppas model, the release rate and release mechanism for CFS granules are governed by a complex quasi-Fickian release mechanism [ 49 ].…”

Section: Resultsmentioning

confidence: 99%

Multiparticulate Systems of Meloxicam for Colonic Administration in Cancer or Autoimmune Diseases

et al. 2022

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The aim of this research is the development of new colonic release systems of meloxicam (MLX) a non-steroidal anti-inflammatory drug (NSAIDs) with pH and time-dependent vehicles for cancer or autoimmune diseases. The colon has a higher pH than the rest of the gastrointestinal tract (GIT) and this can be used as a modified release strategy. Eudragit® polymers are the most widely used synthetic products in the design of colonic release formulations because they might offer mucoadhesiveness and pH-dependent release. Colonic delivery systems produced with pH-dependent and permeable polymers (FS-30D) or with pH-independent and low permeability polymers (NM-30D), must dissolve at a pH range of 6.0–7.0 to delay the release of the drug and prevent degradation in the GIT, before reaching the colon. The conditions prepared to simulate a gastrointestinal transit showed the CNM multiparticulate system, composed of Eudragit® NM and cellulose, as the best release option for MLX with a more sustained release with respect to the other formulations. CNM formulation followed Higuchi and First-order release kinetics, thus MLX release was controlled by a combination of diffusion and polymers swelling/eroding processes.

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“…ES100 is promising in delivering drugs because it is not only insoluble in aqueous media but also nontoxic, nonirritant, biocompatible and permeable, which make drug release controllable. Given that ES100 is characterized by gastro resistance, gastrointestinal targeting, and an effective sustained release of drugs, it becomes an ideal option for targeting colorectal diseases [ 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

One-Pot Self-Assembly of Core-Shell Nanoparticles within Fibers by Coaxial Electrospinning for Intestine-Targeted Delivery of Curcumin

Hou

Zhang

et al. 2023

Foods

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Nanotechniques for curcumin (Cur) encapsulation provided a potential capability to avoid limitations and improve biological activities in food and pharmaceutics. Different from multi-step encapsulation systems, in this study, zein–curcumin (Z–Cur) core-shell nanoparticles could be self-assembled within Eudragit S100 (ES100) fibers through one-pot coaxial electrospinning with Cur at an encapsulation efficiency (EE) of 96% for ES100–zein–Cur (ES100–Z–Cur) and EE of 67% for self-assembled Z–Cur. The resulting structure realized the double protection of Cur by ES100 and zein, which provided both pH responsiveness and sustained release performances. The self-assembled Z–Cur nanoparticles released from fibermats were spherical (diameter 328 nm) and had a relatively uniform distribution (polydispersity index 0.62). The spherical structures of Z–Cur nanoparticles and Z–Cur nanoparticles loaded in ES100 fibermats could be observed by transmission electron microscopy (TEM). Fourier transform infrared spectra (FTIR) and X-ray diffractometer (XRD) revealed that hydrophobic interactions occurred between the encapsulated Cur and zein, while Cur was amorphous (rather than in crystalline form). Loading in the fibermat could significantly enhance the photothermal stability of Cur. This novel one-pot system much more easily and efficiently combined nanoparticles and fibers together, offering inherent advantages such as step economy, operational simplicity, and synthetic efficiency. These core-shell biopolymer fibermats which incorporate Cur can be applied in pharmaceutical products toward the goals of sustainable and controllable intestine-targeted drug delivery.

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Fabrication and characterization of budesonide loaded colon-specific nanofiber drug delivery systems using anionic and cationic polymethacrylate polymers

Cited by 16 publications

References 60 publications

Preparation and Characterization of a Novel Multiparticulate Dosage Form Carrying Budesonide-Loaded Chitosan Nanoparticles to Enhance the Efficiency of Pellets in the Colon

Preparation and Characterization of a Novel Multiparticulate Dosage Form Carrying Budesonide-Loaded Chitosan Nanoparticles to Enhance the Efficiency of Pellets in the Colon

Multiparticulate Systems of Meloxicam for Colonic Administration in Cancer or Autoimmune Diseases

One-Pot Self-Assembly of Core-Shell Nanoparticles within Fibers by Coaxial Electrospinning for Intestine-Targeted Delivery of Curcumin

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