Fabrication and Characterization of a Parylene-Based Three-Dimensional Microelectrode Array for Use in Retinal Prosthesis

Wang, Renxin; Huang, Xinfan; Liu, Guangfeng; Wang, Wei; Fang, Dong; Li, Zhihong

doi:10.1109/jmems.2009.2039773

Cited by 62 publications

(47 citation statements)

References 27 publications

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“…The impedance of electrodes was measured in 0.01 M phosphate-buffered saline (PBS) solution using an impedance analyzer (Agilent 4294A, 40 Hz-110 MHz). A tri-electrode measurement setup consisting of an Ag/AgCl reference electrode and a Pt counter electrode was employed [21]. Fig.…”

Section: B Impedance Testmentioning

confidence: 99%

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Electroplated Nickel Multielectrode Microprobes With Flexible Parylene Cable for Neural Recording and Stimulation

Zheng

Wang

et al. 2013

J. Microelectromech. Syst.

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We design, fabricate, and characterize nickel-based multielectrode microprobes integrated with flexible parylene cable employing low-cost nickel electroplating process, intended for multichannel recording and stimulation of neurons in the brain. Electroplated nickel microprobes, which are encapsulated with parylene for biocompatibility, are more mechanically robust than brittle silicon-based ones. The selectively integrated flexible parylene cable facilitates the connection with external circuits and reduces the packaging requirements. The mechanical and electrical characterizations have been performed. Using the microprobes, the spontaneous neural activity in rat's hippocampus is recorded and the wing beat of tethered worker honeybees is initiated by delivering the stimulating pulse into the optic lobes.[2012-0372]

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Section: B Impedance Testmentioning

confidence: 99%

“…Differing from other biocompatible polymers, moreover, it can be conformably deposited [18] and readily patterned by O 2 plasma etching [19], [20]. Therefore, it is possible to fabricate a complex multilayer flexible structure using these techniques [21], [22].…”

Section: Introductionmentioning

confidence: 99%

Electroplated Nickel Multielectrode Microprobes With Flexible Parylene Cable for Neural Recording and Stimulation

Zheng

Wang

et al. 2013

J. Microelectromech. Syst.

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“…The nanostructures designs based on silicone, to simulate the retina photoreceptor was improved by nanomaterials coating as well as gold and titanium oxide nanoparticles [59]. Whereas, silicon nanowires have been shown to form spontaneous conjunction with photoreceptor cells.…”

Section: Structure and Overview Of Nanowiresmentioning

confidence: 99%

Application of Nanowires for Retinal Regeneration

Kharaghani¹,

Tajbakhsh²,

Phan³

et al. 2020

Regenerative Medicine

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Nanowires aim at developing advanced architectures are gaining popularity for damaged neural systems. The retina with a complicated structure is an essential part of our visual nervous system. Any disorder inside retina could lead to blindness due to irregularity in transferring neural signals to the brain. In recent years, the emergence of nanostructures, as well as nanowires, has provided a viable means for enhancing the regeneration of retinal. Nanowires with the ability to sense light and converting it to the electrical signals simulate the extracellular electrical properties, which are the newest nanostructures for the retinal applications. The different structure of nanowires has been examined in vitro, and several others are undergoing in vivo for vision recovery. Among the structures, core-shell nanowires and functionalized nanowires with gold nanoparticles attract the attention for the regeneration of retinal neural systems. Herein, subsequently provide an introduction to the anatomy of the retina, and retinal disorders, the latest progress in the regeneration of retina and vision using nanowires will be reviewed. Also, the different structures, including core-shell and functionalized nanowires with nanoparticles, will be examined. Eventually, the point of view and perspective of applying nanowire in retinal regeneration will be offered.

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“…These dimensions are chosen in accordance with the neuron described by Mainen et al [43]. The cone style is roughly approximate to a normally used nonplanar electrodes [14][15][16][17][18][19][20]. Its tip angles are approximately 20 degree.…”

Section: Parametrical Geometrymentioning

confidence: 99%

Effects of Microelectrode Array Configuration and Position on the Threshold in Electrical Extracellular Stimulation of Single Nerve Fiber：a Modeling Study

Zhao¹,

Wang²,

Lv³

2013

PIER B

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Abstract-A transient finite-element model has been presented to simulate extracellular potential stimulating in a neural tissue by a nonplanar microelectrode array (MEA). This model allows simulating the extracellular potential and transmembrane voltage by means of a single transient computation performed within single finite element (FE) software. The differential effects of the configuration and position of MEA in electrical extracellular stimulation are analyzed theoretically. 3-D models of single nerve fiber and different MEA are used for the computation of the stimulation induced field potential, whereas a cable model of a nerve fibre is used for the calculation of the transmembrane voltage of the nerve fiber. The position of MEA and the spacing of the microelectrodes are varied while mono-, bi-, tri-, and penta-polar MEAs are applied. The model predicts that the lowest stimulation voltage threshold is obtained in the stimulation with penta-polar MEA. Moreover, the relationships, which exist between the thresholds of the electrical extracellular stimulation and the parameters including position of the electrode array and the spacing of the microelectrodes in array, are studied and obtained.

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Fabrication and Characterization of a Parylene-Based Three-Dimensional Microelectrode Array for Use in Retinal Prosthesis

Cited by 62 publications

References 27 publications

Electroplated Nickel Multielectrode Microprobes With Flexible Parylene Cable for Neural Recording and Stimulation

Electroplated Nickel Multielectrode Microprobes With Flexible Parylene Cable for Neural Recording and Stimulation

Application of Nanowires for Retinal Regeneration

Effects of Microelectrode Array Configuration and Position on the Threshold in Electrical Extracellular Stimulation of Single Nerve Fiber：a Modeling Study

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