Fabrication and characterization of a micromechanical sensor for differential detection of nanoscale motions

Savran, Cagri A.; Sparks, Andrew W.; Sihler, Joachim; Li, Jian; Wu, Wan-Chen; Berlin, Dean; Burg, Thomas P.; Fritz, Jürgen; Schmidt, M.A.; Manalis, Scott R.

doi:10.1109/jmems.2002.805057

Cited by 36 publications

(25 citation statements)

References 14 publications

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“…By employing aptamers as immobilized receptor molecules, the selectivity of microcantilevers toward specific analytes can be improved since non-specific adsorption can be reduced. The work of Savran et al (2002Savran et al ( , 2003Savran et al ( , 2004 was the first attempt at such a device (Fig. 2).…”

Section: Micro-and Nanocantilever Aptasensorsmentioning

confidence: 99%

Emerging applications of aptamers to micro- and nanoscale biosensing

Nguyen

Hilton

Lin

2009

Microfluid Nanofluid

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Micro-and nanofabrication has allowed the production of ultra-sensitive, portable, and inexpensive biosensors. These devices generally rely on chemical or biological receptors which recognize a particular compound of interest and relay this recognition event effectively by transduction. Recent advances in RNA and DNA synthesis have enabled the use of aptamers, in vitro generated oligonucleotides, which offer high affinity biomolecular recognition to a theoretically limitless variety of analytes. DNA and RNA aptamers have gained so much attention in the biosensor community, that they have begun competing with more established affinity ligands including enzymes, lectins, and most notably, immunoreceptors such as antibodies. This article reviews the current state-of-the-art of aptasensors, or biosensors that use aptamers as molecular recognition elements, emphasizing the synergy between aptamer-based biosensing and micro-and nanotechnology. Aptasensors developed on micro-and nanoscale platforms based on mass changes, electroanalytical techniques, optical transduction, and purification and separation methods will be covered.

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Section: Micro-and Nanocantilever Aptasensorsmentioning

confidence: 99%

Emerging applications of aptamers to micro- and nanoscale biosensing

Nguyen

Hilton

Lin

2009

Microfluid Nanofluid

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“…The equations describing the cantilever deflection (4)(5)(6)(7)(8) assume that the strain is small, an assumption that is valid for all of the deflections encountered in our experiments.…”

Section: Microcantilever Sensorsmentioning

confidence: 99%

Model-Based Processing of Microcantilever Sensor Arrays

Tringe

Clague

Candy

et al. 2006

J. Microelectromech. Syst.

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Abstract-We have developed a model-based processor (MBP) for a microcantilever-array sensor to detect target species in solution. We perform a proof-of-concept experiment, fit model parameters to the measured data and use them to develop a Gauss-Markov simulation. We then investigate two cases of interest, averaged deflection data and multi-channel data. For this evaluation we extract model parameters via a model-based estimation, perform a Gauss-Markov simulation, design the optimal MBP and apply it to measured experimental data. The performance of the MBP in the multi-channel case is evaluated by comparison to a "smoother" (averager) typically used for microcantilever signal analysis. It is shown that the MBP not only provides a significant gain (~ 80dB) in signal-to-noise ratio (SNR), but also consistently outperforms the smoother by 40-60 dB. Finally, we apply the processor to the smoothed experimental data and demonstrate its capability for chemical detection. The MBP performs quite well, apart from a correctable systematic bias error.

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“…The most critical parts of all the above actuators may be very small; however, as large energy is required, they usually have to use external electrical power supply sources connected to the microsystems through wires, which will result in device packaging difficulties, weak mobility, electrical interference, or an enlarged device size. Therefore, several researchers adopted laser as the direct power to heat the actuator (Chen et al, 1998;Lalinský et al, 2005;Pichonat et al, 2004;Poosanaas et al, 2000;Savran et al, 2002). They all have obtained various degrees of success, but due to their complex manufacture they are hard to be applied practically.…”

Section: Introductionmentioning

confidence: 99%

Microscopic observation and laser‐controlled microoptothermal drive mechanism

Zhang

Liu

et al. 2007

Microscopy Res & Technique

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The mechanism of novel optothermal microactuators (OTA) was analyzed with a microscope system, a charge-coupled device-combined light microscope, and a computer system. One OTA, two optothermal microswitches (OTS) with different length and shape were machined by an excimer laser micromatching system using single layer material. They all had two thin expansion arms with different widths. The mechanism of the OTA/OTS is that the different optothermal expansion controlled by asymmetric topology and shape of the arms causes a magnified lateral deflection or vibration. A red laser diode (650 nm) with maximum power output of 30 mW was employed as the external power source to drive the OTA/OTS. Experiments were carried out with the microscope system, and serial images and videos were acquired. The results indicate that the structure of the OTA/OTS is simple and easy to be manufactured. They can practically generate an obvious lateral deflection or vibration. When the location of the laser spot on the OTA changed, the direction of its deflection is also changed. When the value of laser power that irradiated on the OTS increased, the lateral deflection of the OTS enlarged, the maximum could be larger than 30 microm. This kind of novel microactuator has the advantages of remote wireless controlling, large displacement, simple structure, easy to be machined, and therefore will be quite useful for the practical applications in the fields of micro/nanotechnology.

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Fabrication and characterization of a micromechanical sensor for differential detection of nanoscale motions

Cited by 36 publications

References 14 publications

Emerging applications of aptamers to micro- and nanoscale biosensing

Emerging applications of aptamers to micro- and nanoscale biosensing

Model-Based Processing of Microcantilever Sensor Arrays

Microscopic observation and laser‐controlled microoptothermal drive mechanism

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