Fabrication and characterization of a porous silicon based microarray for label-free optical monitoring of biomolecular interactions

Rea, Ilaria; Lamberti, Annalisa; Rendina, Ivo; Coppola, Giuseppe; Gioffrè, M.; Iodice, Mario; Casalino, Maurizio; Tommasi, Edoardo De; Stefano, Luca De

doi:10.1063/1.3273410

Cited by 50 publications

(38 citation statements)

References 20 publications

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“…An intense visible photoluminescence of PS, its anti-reflective properties and band gap increased due to the quantum confined effect in silicon nanocrystals give a perspective of PS use in optoelectronics and photonics [15,16]. High chemical and adsorption sensitivity of large internal surface PS is actively exploited in the touch-sensing electronics and biomedical technologies [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Effect of Graphene Oxide on the Properties of Porous Silicon

Olenych¹,

Aksimentyeva²,

Monastyrskii³

et al. 2017

Nano Online

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We studied an effect of the graphene oxide (GO) layer on the optical and electrical properties of porous silicon (PS) in hybrid PS-GO structure created by electrochemical etching of silicon wafer and deposition of GO from water dispersion on PS. With the help of scanning electron microscopy (SEM), atomic-force microscopy (AFM), and Fourier transform infrared (FTIR) spectroscopy, it was established that GO formed a thin film on the PS surface and is partly embedded in the pores of PS. A comparative analysis of the FTIR spectra for the PS and PS-GO structures confirms the passivation of the PS surface by the GO film. This film has a sufficient transparency for excitation and emission of photoluminescence (PL). Moreover, GO modifies PL spectrum of PS, shifting the PL maximum by 25 nm towards lower energies. GO deposition on the surface of the porous silicon leads to the change in the electrical parameters of PS in AC and DC modes. By means of current-voltage characteristics (CVC) and impedance spectroscopy, it is shown that the impact of GO on electrical characteristics of PS manifests in reduced capacitance and lower internal resistance of hybrid structures.

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Section: Introductionmentioning

confidence: 99%

Effect of Graphene Oxide on the Properties of Porous Silicon

Olenych¹,

Aksimentyeva²,

Monastyrskii³

et al. 2017

Nano Online

View full text Add to dashboard Cite

show abstract

“…An intense visible photoluminescence of PS, its anti-reflective properties and band gap increased due to the quantum confined effect in silicon nanocrystals give a perspective of PS use in optoelectronics and photonics [ 15 , 16 ]. High chemical and adsorption sensitivity of large internal surface PS is actively exploited in the touch-sensing electronics and biomedical technologies [ 17 – 20 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Graphene Oxide on the Properties of Porous Silicon

et al. 2016

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We studied an effect of the graphene oxide (GO) layer on the optical and electrical properties of porous silicon (PS) in hybrid PS–GO structure created by electrochemical etching of silicon wafer and deposition of GO from water dispersion on PS. With the help of scanning electron microscopy (SEM), atomic-force microscopy (AFM), and Fourier transform infrared (FTIR) spectroscopy, it was established that GO formed a thin film on the PS surface and is partly embedded in the pores of PS. A comparative analysis of the FTIR spectra for the PS and PS–GO structures confirms the passivation of the PS surface by the GO film. This film has a sufficient transparency for excitation and emission of photoluminescence (PL). Moreover, GO modifies PL spectrum of PS, shifting the PL maximum by 25 nm towards lower energies. GO deposition on the surface of the porous silicon leads to the change in the electrical parameters of PS in AC and DC modes. By means of current–voltage characteristics (CVC) and impedance spectroscopy, it is shown that the impact of GO on electrical characteristics of PS manifests in reduced capacitance and lower internal resistance of hybrid structures.

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“…Recently, we have proposed a microarray of porous silicon (Psi) one-dimensional photonic crystals as a functional platform for label-free detection of biomolecular interactions. 8 PSi is by far an attractive support for the immobilization of biological probes due to its sponge-like morphology, constituted by a network of air holes in the silicon matrix, and characterized by a specific surface area of the order of hundreds of square meters per cubic centimetres. 9 PSi can be fabricated by electrochemical etching of doped crystalline silicon in hydrofluoridric acid: 10 since the dissolution process is self-stopping, the content of voids, and thus the dielectric properties, and in particular the refractive index of each silicon layer can be finely tuned by a proper setting of the process parameters.…”

Section: Introductionmentioning

confidence: 99%

A microfluidics assisted porous silicon array for optical label-free biochemical sensing

et al. 2011

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A porous silicon (PSi) based microarray has been integrated with a microfluidic system, as a proof of concept device for the optical monitoring of selective label-free DNA-DNA interaction. A 4 × 4 square matrix of PSi one dimensional photonic crystals, each one of 200 μm diameter and spaced by 600 μm, has been sealed by a polydimethylsiloxane (PDMS) channels circuit. The PSi optical microarray elements have been functionalized by DNA single strands after sealing: the microfluidic circuit allows to reduce significantly the biologicals and chemicals consumption, and also the incubation time with respect to a not integrated device. Theoretical calculations, based on finite element method, taking into account molecular interactions, are in good agreement with the experimental results, and the developed numerical model can be used for device optimization. The functionalization process and the interaction between DNA probe and target has been monitored by spectroscopic reflectometry for each PSi element in the microchannels.

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Fabrication and characterization of a porous silicon based microarray for label-free optical monitoring of biomolecular interactions

Cited by 50 publications

References 20 publications

Effect of Graphene Oxide on the Properties of Porous Silicon

Effect of Graphene Oxide on the Properties of Porous Silicon

Effect of Graphene Oxide on the Properties of Porous Silicon

A microfluidics assisted porous silicon array for optical label-free biochemical sensing

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