Fabrication and characterization of a novel fluffy polypyrrole fibrous scaffold designed for 3D cell culture

Jin, Lin; Wang, Ting; Feng, Zhang‐Qi; Zhu, Mingzhao; Leach, Michelle K.; Naim, Youssef; Jiang, Qing

doi:10.1039/c2jm32165c

Cited by 55 publications

(64 citation statements)

References 42 publications

(40 reference statements)

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“…[ 20 ] This electrical performance was much higher than that of the commonly used e-NFs for cellular electrical stimulation such as conductive polymer nanofi bers (≈5.5 S cm −1 ). [29][30][31] The excellent electrical conductivity was contributed by the formation of graphene shells on the surface of nanofi bers with the spatial continuous graphene sheets. In addition, in this coupled material system, no polymeric insulator obstructs the 2D confi ned pseudoballistic electronic transports among the G-NFs, which often occurred in other conductive materials doped nanofi bers.…”

Section: Doi: 101002/adma201503319mentioning

confidence: 99%

Soft Graphene Nanofibers Designed for the Acceleration of Nerve Growth and Development

et al. 2015

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Soft graphene nanofibers with recoverable electrical conductivity and excellent physicochemical stability are prepared by a controlled assembly technique. By using the soft graphene nanofibers for cellular electrical stimulation, the common inhibitory effect of long-term electrical stimulation on nerve growth and development is avoided, which usually happens with traditional 2D conductive materials.

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Section: Doi: 101002/adma201503319mentioning

confidence: 99%

Soft Graphene Nanofibers Designed for the Acceleration of Nerve Growth and Development

et al. 2015

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“…The increased cell proliferation may be due to induced membrane depolarisation from the electrical stimulation, stimulating Ca 2+ ionic transport and upregulating gene pathways. 34 Polypyrrole (PPy) has been shown to be compatible with cardiac cells 35,36 , and has been used to directly stimulate cells via electrical 37,38 and mechanical 39,40 stimulus.…”

Section: Introductionmentioning

confidence: 99%

Optimisation of conductive polymer biomaterials for cardiac progenitor cells

et al. 2016

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The characterisation of biomaterials for cardiac tissue engineering applications is vital for the development of effective treatments for the repair of cardiac function. New smart materials developed from conductive polymers can provide dynamic benefits in supporting and stimulating stem cells via controlled surface properties, electrical and electromechanical stimulation. In this study we investigate the control of surface properties of conductive polymers through a systematic approach to variable synthesis parameters, and how the resulting surface properties influence the viability of cardiac progenitor cells. A thorough analysis investigating the effect of electropolymerisation parameters, such as current density and growth, and reagent variation on physical properties provides a fundamental understanding of how to optimise conductive polymer biomaterials for cardiac progenitor cells.

Funding Agencies|Linkoping University; IGEN (post-doc grant); COST-Action [MP1003]; Knut och Alice Wallenberg Commemorative Fund; European Research Agency

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“…Another approach used for improving specific functionalities of the electrospun scaffolds is polymerization on the surface of the fibers. Jin et al polymerized pyrrole on the surface of PLLA scaffold, creating discrete hollow polypyrrole (PPy) fibers with deep (100 μm) interconnected pores [151]. This structure allowed the entry of CMs and showed excellent results for proliferation and morphology of the cultured cells.…”

Section: Co-electrospinning With Conductive Materialsmentioning

confidence: 99%

Fibers for hearts: A critical review on electrospinning for cardiac tissue engineering

et al. 2017

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Please cite this article as: Kitsara, M., Agbulut, O., Kontziampasis, D., Chen, Y., Menasché, P., Fibers for hearts: A critical review on electrospinning for cardiac tissue engineering, Acta Biomaterialia (2016), doi: http://dx.doi.org/ 10. 1016/j.actbio.2016.11.014 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractCardiac cell therapy holds a real promise for improving heart function and especially of the chronically failing myocardium. Embedding cells into 3D biodegradable scaffolds may better preserve cell survival and enhance cell engraftment after transplantation, consequently improving cardiac cell therapy compared with direct intramyocardial injection of isolated cells.The primary objective of a scaffold used in tissue engineering is the recreation of the natural 3D environment most suitable for an adequate tissue growth. An important aspect of this commitment is to mimic the fibrillar structure of the extracellular matrix, which provides essential guidance for cell organization, survival, and function. Recent advances in nanotechnology have significantly improved our capacities to mimic the extracellular matrix. Among them, electrospinning is well known for being easy to process and cost effective. Consequently, it is becoming increasingly popular for biomedical applications and it is most definitely the cutting edge technique to make scaffolds that mimic the extracellular matrix for industrial applications.Here, the desirable physico-chemical properties of the electrospun scaffolds for cardiac therapy are described, and polymers are categorized to natural and synthetic. Moreover, the methods used for improving functionalities by providing cells with the necessary chemical cues and a more in vivo-like environment are reported.

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Fabrication and characterization of a novel fluffy polypyrrole fibrous scaffold designed for 3D cell culture

Cited by 55 publications

References 42 publications

Soft Graphene Nanofibers Designed for the Acceleration of Nerve Growth and Development

Soft Graphene Nanofibers Designed for the Acceleration of Nerve Growth and Development

Optimisation of conductive polymer biomaterials for cardiac progenitor cells

Fibers for hearts: A critical review on electrospinning for cardiac tissue engineering

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