Fabrication and assessment of bifunctional electrospun poly(l-lactic acid) scaffolds with bioglass and zinc oxide nanoparticles for bone tissue engineering

Venus antiqua Clamshell-Derived Calcium Oxide Nanoparticles for the Preparation of PLA/d-Limonene/CaO Nanocomposites with Antimicrobial Properties

“…Poly­(lactic acid) (PLA) was used from MCI electronics (1.75 mm filaments, Sakata 3D filament) with an average molecular weight of M w = 335,173 g/mol. , V. antiqua clamshells from the Chilean Pacific coast were used to synthesize the nanoparticles.…”

“…Poly(lactic acid) (PLA) was used from MCI electronics (1.75 mm filaments, Sakata 3D filament) with an average molecular weight of M w = 335,173 g/mol. 45,46 V. antiqua clamshells from the Chilean Pacific coast were used to synthesize the nanoparticles. In addition, As plasticizer was used D-limonene (Aldrich, reagent grade 97%) and ethanol (Winkler, 95%) was used as a solvent for the antimicrobial test.…”

Biomimetic Mineralization of Mn-Doped Biphasic Calcium Phosphate in the GelMa Hydrogel Acting as a Functional 3D Bioscaffold for Osteo Defect Repair

“…Extrusion-based 3D bioprinting uses hydrogels, which effectively encapsulate cells inside them, providing better biocompatibility and reducing shear stress during the extrusion process . Unfortunately, available hydrogel materials do not provide sufficient mechanical strength, which is required during the defect repair process. , Due to the inferior mechanical strength of the hydrogel, there is an immense need to look for a secondary approach. In the case of the bioactivity of the scaffold, incorporation of growth factors such as TGF-β3, BMP-2, and VEGF is employed in the hydrogel scaffolds, which are used to drive cells into the osteogenic lineage, but the half-life of the growth factor limits its applicability.…”

“…1 This biomaterialsbased approach resolves the challenges associated with the use of autologous and allogenic grafts, where they cause donor site morbidity, limited source availability, immunological reactions, and disease transmission. 2,3 On the other hand, the fabrication of functional synthetic bone grafts is a complicated, dynamic process that involves the selection of material, cells, and stimulating cues. 4−6 Various approaches have been widely utilized for the fabrication of bone implants, such as casting, freeze-drying, salt leaching, electrospinning, and additive manufacturing.…”

“…Bone tissue engineering is an emerging field that involves the regeneration of bone defects using implants/scaffolds constructed of biomaterials in clinical research . This biomaterials-based approach resolves the challenges associated with the use of autologous and allogenic grafts, where they cause donor site morbidity, limited source availability, immunological reactions, and disease transmission. , On the other hand, the fabrication of functional synthetic bone grafts is a complicated, dynamic process that involves the selection of material, cells, and stimulating cues. − Various approaches have been widely utilized for the fabrication of bone implants, such as casting, freeze-drying, salt leaching, electrospinning, and additive manufacturing. These techniques make it possible to develop a 3-dimensional (3D) scaffold, but each of the mentioned techniques holds advantages as well as disadvantages .…”