Fabrication and applications of bioactive chitosan-based organic-inorganic hybrid materials: A review

Liu, Xiaoyang; Wu, Yuxuan; Zhao, Xinchen; Wang, Zhengke

doi:10.1016/j.carbpol.2021.118179

Cited by 50 publications

(31 citation statements)

References 252 publications

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“…The reason why CS–GO nanocomposites are mostly utilized for bone tissue engineering is that the molecular structure of CS is similar to glycosaminoglycan (a major component of bone extracellular matrix) ( Liu et al., 2021b ) and GO shows the ability to promote osteogenic differentiation when combined with CS ( Francolini et al., 2019 ). The prepared CS–GO nanocomposites are normally 3D matrices ( i.e.…”

Section: Bone Tissue Engineeringmentioning

confidence: 99%

“…Importantly, thanks to abundant amino and hydroxyl active groups on CS main chain, it is easy to modify CS through a variety of interactions such as covalent bonding, hydrogen bonding, and electrostatic interactions, thus conquering its defects of poor mechanical property and solubility ( Croisier and Jérôme, 2013 ). The modification methods can be classified as chemical modification ( Jayakumar et al., 2005 ), adding plasticizers ( Thakhiew et al., 2015 ) or a new polymer network, and introducing nanoparticles including carbon-based nanoparticles, polymeric nanoparticles, and inorganic nanoparticles ( Chen et al., 2020b ; Liu et al., 2021b ; Wahid et al., 2020 ). Among them, the combination with graphene oxide (GO) has attracted great attention.…”

Section: Introductionmentioning

confidence: 99%

“…Although judging from the preliminary literature, CS–GO nanocomposites are superb absorbents for dyes and heavy metals which are the two most common water pollutants in daily life ( Liu et al., 2021b ), and excellent antimicrobial materials in the food industry, their strengths are still more reflected in biomedical science. Therefore, the focus of this review is to present the main direction of biomedical applications of CS–GO nanocomposites with specially made functionalities in recent years ( Table 1 ).…”

Section: Introductionmentioning

confidence: 99%

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Biomedical applications of chitosan-graphene oxide nanocomposites

Feng¹,

Wang²

2022

iScience

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Summary Chitosan (CS) and graphene oxide (GO) nanocomposites have received wide attention in biomedical fields due to the synergistic effect between CS which has excellent biological characteristics and GO which owns great physicochemical, mechanical, and optical properties. Nanocomposites based on CS and GO can be fabricated into a variety of forms, such as nanoparticles, hydrogels, scaffolds, films, and nanofibers . Thanks to the ease of functionalization, the performance of these nanocomposites in different forms can be further improved by introducing other functional polymers, nanoparticles, or growth factors. With this background, the current review summarizes the latest developments of CS–GO nanocomposites in different forms and compositions in biomedical applications including drug and biomacromolecules delivery, wound healing, bone tissue engineering, and biosensors. Future improving directions and challenges for clinical practice are proposed as well.

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Section: Bone Tissue Engineeringmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biomedical applications of chitosan-graphene oxide nanocomposites

Feng¹,

Wang²

2022

iScience

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“…Chitosan ((C6H11NO4)n) and hydroxyapatite (Ca10(PO4)6(OH)2) coatings, as well as their derived compounds, represent a class of material intensely studied in recent years for bone tissue engineering in biomedical applications [1][2][3][4]. In the research areas of orthopedics and cancer surgery [4,5], any type of calcium phosphate such as amorphous calcium phosphate, dicalcium phosphate, tricalcium phosphate, or octacalcium phosphate proved its utility for complex tissue repair and regeneration, reinforcement efficiency, bone engineering and therapeutic ions release.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Electron Beam Irradiation on the Morphological and Physicochemical Properties of Magnesium-Doped Hydroxyapatite/Chitosan Composite Coatings

et al. 2022

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This work reports on the influence of 5 MeV electron beam radiations on the morphological features and chemical structure of magnesium-doped hydroxyapatite/chitosan composite coatings generated by the magnetron sputtering technique. The exposure to ionizing radiation in a linear electron accelerator dedicated to medical use has been performed in a controllable manner by delivering up to 50 Gy radiation dose in fractions of 2 Gy radiation dose per 40 s. After the irradiation with electron beams, the surface of layers became nano-size structured. The partial detachment of irradiated layers from the substrates has been revealed only after visualizing their cross sections by scanning electron microscopy. The energy dispersive X-ray spectral analysis of layer cross-sections indicated that the distribution of chemical elements in the samples depends on the radiation dose. The X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy and X-ray diffraction analysis have shown that the physicochemical processes induced by the ionizing radiation in the magnesium doped hydroxyapatite/chitosan composite coatings do not alter the apatite structure, and Mg remains bonded with the phosphate groups.

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“…To overcome these problems, alternative approaches have been developed to improve the fabrication of 3D hierarchical organic-inorganic hybrid structures [17][18][19]. Sasidharan et al reported 3D polymer-metal-carbon hybrid materials to remove biological contaminants and provide antibacterial performance [20].…”

Section: Introductionmentioning

confidence: 99%

3D Hierarchical Polyaniline–Metal Hybrid Nanopillars: Morphological Control and Its Antibacterial Application

et al. 2021

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Effective and reliable antibacterial surfaces are in high demand in modern society. Although recent works have shown excellent antibacterial performance by combining unique hierarchical nanotopological structures with functional polymer coating, determining the antibacterial performance arising from morphological changes is necessary. In this work, three-dimensional (3D) hierarchical polyaniline–gold (PANI/Au) hybrid nanopillars were successfully fabricated via chemical polymerization (i.e., dilute method). The morphology and structures of the PANI/Au nanopillars were controlled by the reaction time (10 min to 60 h) and the molar concentrations of the monomer (0.01, 0.1, and 1 M aniline), oxidant (0.002, 0.0067, 0.01, and 0.02 M ammonium persulfate), and acid (0.01, 0.1, 1, and 2 M perchloric acid). These complex combinations allow controlling the hierarchical micro- to nanostructure of PANI on a nanopillar array (NPA). Furthermore, the surface of the 3D PANI/Au hierarchical nanostructure can be chemically treated while maintaining the structure using initiated chemical vapor deposition. Moreover, the excellent antibacterial performance of the 3D PANI/Au hierarchical nanostructure (HNS) exceeds 99% after functional polymer coating. The excellent antibacterial performance of the obtained 3D PANI/Au HNS is mainly because of the complex topological and physicochemical surface modification. Thus, these 3D PANI/Au hierarchical nanostructures are promising high-performance antibacterial materials.

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Fabrication and applications of bioactive chitosan-based organic-inorganic hybrid materials: A review

Cited by 50 publications

References 252 publications

Biomedical applications of chitosan-graphene oxide nanocomposites

Biomedical applications of chitosan-graphene oxide nanocomposites

The Effects of Electron Beam Irradiation on the Morphological and Physicochemical Properties of Magnesium-Doped Hydroxyapatite/Chitosan Composite Coatings

3D Hierarchical Polyaniline–Metal Hybrid Nanopillars: Morphological Control and Its Antibacterial Application

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