Fabrication and application of graphene oxide modified cyclodextrin chiral separation membranes

Zhu, Yining; Li, X.L.; Bai, Z. G.; Zeng, Yu‐Jia; Han, Jonghee; Bai, Xiaojing; Li, Ruijun

doi:10.1039/d3nj01309j

Cited by 4 publications

(4 citation statements)

References 29 publications

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“…The enantiomeric separation performance was investigated by testing the separation of chiral drugs. The obtained membrane showed 3% better selectivity for racemic R/S-tryptophan than the nongraphene oxide membrane . Milovanovic and coauthors have developed an organic–inorganic double network within an organic polymeric membrane for chiral separation.…”

Section: Challenges and Future Perspectivesmentioning

confidence: 99%

“…The obtained membrane showed 3% better selectivity for racemic R/S-tryptophan than the nongraphene oxide membrane. 211 Milovanovic and coauthors have developed an organic–inorganic double network within an organic polymeric membrane for chiral separation. The designed membrane showed good separation of R- and S-naproxen.…”

Section: Challenges and Future Perspectivesmentioning

confidence: 99%

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Organic Solvent Nanofiltration in Pharmaceutical Applications

Xiao,

Feng,

Goundry

et al. 2024

Org. Process Res. Dev.

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Separation and purification in organic solvents are indispensable procedures in pharmaceutical manufacturing. However, they still heavily rely on the conventional separation technologies of distillation and chromatography, resulting in high energy and massive solvent consumption. As an alternative, organic solvent nanofiltration (OSN) offers the benefits of low energy consumption, low solid waste generation, and easy scale-up and incorporation into continuous processes. Thus, there is a growing interest in employing membrane technology in the pharmaceutical area to improve process sustainability and energy efficiency. This Review comprehensively summarizes the recent progress (especially the last 10 years) of organic solvent nanofiltration and its applications in the pharmaceutical industry, including the concentration and purification of active pharmaceutical ingredients, homogeneous catalyst recovery, solvent exchange and recovery, and OSN-assisted peptide/oligonucleotide synthesis. Furthermore, the challenges and future perspectives of membrane technology in pharmaceutical applications are discussed in detail.

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Section: Challenges and Future Perspectivesmentioning

confidence: 99%

Section: Challenges and Future Perspectivesmentioning

confidence: 99%

Organic Solvent Nanofiltration in Pharmaceutical Applications

Xiao,

Feng,

Goundry

et al. 2024

Org. Process Res. Dev.

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show abstract

“…14 In this way, MMMs can associate the properties of inorganic particles with the properties of polymers, making it possible to achieve greater selectivity and permeability. 15,16 Recently, different nanoporous materials were used for the separation of chiral compounds, such as graphene oxides (GOs), [17][18][19][20] metal-organic frameworks (MOFs) 21,22 and covalent organic frameworks (COFs). 14,23 Nanostructured mesoporous materials, such as MCM-41 from the M41S family, demonstrated an excellent choice for insertion of Pirkle-type chiral selectors, as these materials have high surface areas and well-defined pore sizes 24,25 as revealed in our previous work.…”

Section: Introductionmentioning

confidence: 99%