Fabrication and Analysis of Polydimethylsiloxane (PDMS) Microchannels for Biomedical Application

Abstract

In this research work, Polydimethylsiloxane (PDMS) has been used for the fabrication of microchannels for biomedical application. Under the internet of things (IoT)-based controlled environment, the authors have simulated and fabricated bio-endurable, biocompatible and bioengineered PDMS-based microchannels for varicose veins implantation exclusively to avoid tissue damaging. Five curved ascending curvilinear micro-channel (5CACMC) and five curved descending curvilinear micro-channels (5CDCMC) are simulated by MATLAB (The Math-Works, Natick, MA, USA) and ANSYS (ANSYS, The University of Lahore, Pakistan) with actual environments and confirmed experimentally. The total length of each channel is 1.6 cm. The diameter of both channels is 400 µm. In the ascending channel, the first to fifth curve cycles have the radii of 2.5 mm, 5 mm, 7.5 mm, 10 mm, and 2.5 mm respectively. In the descending channel, the first and second curve cycles have the radii of 12.5 mm and 10 mm respectively. The third to fifth cycles have the radii of 7.5 mm, 5 mm, and 2.5 mm respectively. For 5CACMC, at Reynolds number of 185, the values of the flow rates, velocities and pressure drops are 19.7 µLs−1, 0.105 mm/s and 1.18 Pa for Fuzzy simulation, 19.3 µLs−1, 0.1543 mm/s and 1.6 Pa for ANSYS simulation and 18.23 µLs−1, 0.1332 mm/s and 1.5 Pa in the experiment. For 5CDCMC, at Reynolds number 143, the values of the flow rates, velocities and pressure drops are 15.4 µLs−1, 0.1032 mm/s and 1.15 Pa for Fuzzy simulation, 15.0 µLs−1, 0.120 mm/s and 1.22 Pa for ANSYS simulation and 14.08 µLs−1, 0.105 mm/s and 1.18 Pa in the experiment. Both channels have three inputs and one output. In order to observe Dean Flow, Dean numbers are also calculated. Therefore, both PDMS channels can be implanted in place of varicose veins to have natural blood flow.

Two-dimensional biocompatible plasmonic contact lenses for color blindness correction

“…PDMS is a biocompatible, flexible, and transparent material which can be a good candidate for fabricating contact lenses. This nontoxic and biocompatible material has attracted many applications in fields such as biology 30 – 34 , medicine 35 , 36 , and chemistry 37 . In this work, a 2D flexible and biocompatible PDMS-based lens was successfully fabricated using a low-cost, and simple design based on the soft nano-lithography method and investigated for correction of red-green color blindness.…”

Effects of the Magnetohydrodynamic Flow within the Boundary Layer of a Jeffery Fluid in a Porous Medium over a Shrinking/Stretching Sheet

“…A two-dimensional (x, y) MHD stream of incompressible Jeffrey liquid flows across a y � 0 shrinking/stretching sheet. In standard notation, the MHD Jeffery fluid flow and temperature equations are expressed as (ref [28] and [29])…”

“…Transmission has gained a lot of traction. e relevant studies comprise Afzal et al [27], Afzal et al [28], and Tayyaba et al [29].…”

Numerical Simulation, Analysis, and Fabrication of MEMS-Based Solid Ag and Cu Microneedles for Biomedical Applications

“…ese biomaterials exhibit exceptional properties in protecting the cardiac system, helping bone fracture healing, and employing antibacterial effects [55][56][57][58][59][60]. In this research, we have fabricated solid silver and copper microneedles by using an economical technique of electrochemical etching.…”