Fabricating Oxidized Cellulose Sponge for Hemorrhage Control and Wound Healing

Abstract

Uncontrolled hemorrhage and infection are the main reasons for many trauma-related deaths in both clinic and battlefield. However, most hemostatic materials have various defects and side effects, such as low hemostatic efficiency, poor biocompatibility, weak degradation ability, and lack of antimicrobial properties. Herein, an oxidized cellulose (OC) sponge with antibacterial properties and biosafety was fabricated for hemorrhage control and wound healing. The as-prepared OC sponges were prone to water triggered expansion and superabsorbent capacity, which could facilitate blood component concentration effectively. Importantly, they had significant biodegradability with little irritation to the skin. This hemostat could also reduce the plasma clotting time to 53.54% in vitro and demonstrated less blood loss than commercially available hemostatic agents (GS) in a mouse model of bleeding from liver defects. Furthermore, the biocompatibility antimicrobial properties and possible hemostatic mechanism of the OC sponge were also systematically evaluated. Importantly, the potential wound healing applications have also been demonstrated. Therefore, the materials have broad clinical application prospects.

Advancing Bioactive Material for Mandibular Bone Regeneration: Transformation of Fibrous Mat into 3D Matrix Cotton for Enhanced Shape Retention and Rapid Hemostasis

“…The assessment of water and blood absorptivity provides valuable insights into the ability of matrix cotton to retain and interact with fluids, mimicking physiological conditions in biological systems . Water absorptivity serves as a crucial indicator, reflecting the material’s capacity to maintain hydration, which in turn affects its mechanical stability and compatibility with biological tissues.…”

“…The assessment of water and blood absorptivity provides valuable insights into the ability of matrix cotton to retain and interact with fluids, mimicking physiological conditions in biological systems. 30 Water absorptivity serves as a crucial indicator, reflecting the material's capacity to maintain hydration, which in turn affects its mechanical stability and compatibility with biological tissues. On the other hand, blood absorptivity demonstrates how the scaffold absorbs and retains blood, particularly important in applications involving vascularized tissues or implants interfacing with blood circulation.…”

Composite Aerogel Scaffolds Containing Flexible Silica Nanofiber and Tricalcium Phosphate Enable Skin Regeneration

“…Wound healing is a dynamic process, which involves multiple overlapping phases, such as homeostasis, granulation tissue formation, matrix deposition, and epithelialization. , While skin exhibits an intrinsic healing capability, in several conditions, such as chronic nonhealing wounds, prolonged inflammation, and poor vascularization, skin repair may be impaired . Wound dressings with characteristics, including air permeability, rapid hemostatic ability, and vasculogenic ability, may offer a promising platform for the healing of chronic skin wounds. , …”

“…46 Wound dressings with characteristics, including air permeability, rapid hemostatic ability, and vasculogenic ability, may offer a promising platform for the healing of chronic skin wounds. 47,48 Electrospun fibers are often used to incorporate different types of bioactive cues to influence cell adhesion, migration, and proliferation and have been intensively studied for regenerative medicine and TE application, including skin repair. 49 Nevertheless, 2D fibrous membranes with poor air permeability and limited moisture absorption may obscure wound healing presumably due to the less diffusion of oxygen as well as minimal transport of nutrients.…”