FABP7 Progenitors are a Targetable Metabolic Root in theBRCA1Breast
Curtis W. McCloskey,
Bowen Zhang,
Matthew Waas
et al.
Abstract:It has been nearly 3 decades since the discovery of theBRCA1/2genes and their link to breast cancer risk, with prophylactic mastectomy remaining the primary management option for these high-risk mutation carriers. The current paucity of interception strategies is due to undefined, targetable cancer precursor populations in the high-risk breast. Despite known cellular alterations in theBRCA1breast, epithelial populations at the root of unwarranted cell state transitions remain unresolved. Here, we identify a ro… Show more
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