FABP2, LEPR223, LEP656, and FTO Polymorphisms: Effect on Weight Loss 2 Years After Bariatric Surgery

Kops, Natália Luiza; Vivan, Manoela Astolfi; Horvath, Jaqueline Driemeyer Correia; Castro, Marcelo Peduzzi de; Friedman, Rogério

doi:10.1007/s11695-018-3213-0

Cited by 17 publications

(7 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the results of these studies need to be replicated to determine better the influence of specific SNPs on the variability of success in weight loss after surgery over time. This is the case for the FTO rs9939609 gene polymorphism with have positive and negative studies regarding weight loss at different time points after bariatric surgery 31–35 . Furthermore, our findings regarding the UCP2 gene polymorphisms (rs659366) did not replicate with the results of another study 28 with the Brazilian cohort after 1 year of RYGB surgery.…”

Section: Discussioncontrasting

confidence: 87%

Lack of association between 11 gene polymorphisms on weight loss 1 year after Roux‐en‐y gastric bypass surgery in woman

Novais

Crisp

Leandro-Merhi

et al. 2022

J Human Nutrition Diet

View full text Add to dashboard Cite

Background Although effective, the impact of bariatric surgery on weight loss is variable, and little is known about the influence of single‐nucleotide polymorphisms (SNPs). The present study investigated the association of eleven SNPs related to obesity with weight loss 1 year after Roux‐Y gastric bypass (RYGB) surgery in female patients. Methods This prospective study included 351 women with obesity. The genotypes for eleven SNPs (GHRL–rs26802; GHSR–rs572169; LEP–rs7799039; LEPR–rs1137101; 5HT2C–rs3813929; UCP2–rs659366; UCP3–rs1800849; SH2B1–rs7498665; TAS1R2–rs35874116; TAS1R2–rs9701796; FTO–rs9939609) were determined using a real‐time polymerase chain reaction and TaqMan assays. Anthropometric measurements were performed before and 1 year after RYGB surgery. To evaluate the factors that influenced the proportion of weight loss 1 year after surgery, beta regression analysis was used. The models were estimated using the GLIMMIX procedure in SAS statistical software. p < 0.05 was considered statistically significant. Results The mean ± SD percentage of total body weight loss in 1 year was 64.4 ± 5.8% and the median was 65.0%. When assessing the proportion of weight loss in 1 year after surgery, using univariate analysis (beta regression), no SNPs influenced weight loss. Furthermore, in the multiple analysis, with stepwise process of variable selection, no variable was significant to compose the multiple model. Conclusions The 11 SNPs investigated did not influence weight loss 1 year after RYGB surgery in female patients. This result indicates that individual behaviours and other factors might better contribute to the magnitude of loss weight loss in a short period after bariatric surgery.

show abstract

Section: Discussioncontrasting

confidence: 87%

Lack of association between 11 gene polymorphisms on weight loss 1 year after Roux‐en‐y gastric bypass surgery in woman

Novais

Crisp

Leandro-Merhi

et al. 2022

J Human Nutrition Diet

View full text Add to dashboard Cite

show abstract

“…Six articles examined the association of either leptin or the leptin receptor genes (LEP/LEPR) with weight loss after bariatric surgery (Table 2). Between 12 and 24 months after RYGB, Kops et al noted that patients with the rs1137101 variant of LEP223 experienced a greater percent excess weight loss [23]. De Luis et al also found patients had better weight loss outcomes with a rs1805094 mutation in LEPR after BPD [24].…”

Section: Leptinmentioning

confidence: 99%

A Systematic Review of Genetic Correlates of Weight Loss After Bariatric Surgery

et al. 2021

View full text Add to dashboard Cite

This systematic review synthesized research evaluating the relationship between genetic predictors and weight loss after bariatric surgery. Fifty-seven studies were identified that examined single genes or genetic risk scores. Uncoupling protein (UCP) rs660339 was associated with excess weight loss after surgery in 4 of 6 studies. The most commonly assessed genes were fat mass and obesity-associated (FTO) gene (n = 10) and melanocortin-4 receptor (MC4R) (n = 14). Both were inconsistently related to weight loss. Genetic risk scores predicted weight loss in 6 of 7 studies. This evidence suggests the potential of using genetic variants and genetic risk scores to predict the amount of weight loss anticipated after bariatric surgery and identify patients who may be at risk for suboptimal weight reduction.

show abstract

“…This variant, represented in eight (of 10 studies) by the SNP rs9939609, is variably associated with weight loss (Table 2). For example, in four studies, no statistically significant association was found with weight loss 45,63,67,73 . Two studies found a positive association with short‐term weight loss 3–6 months post‐surgery, while longer‐term weight loss showed no association with the presence of this variant in patients undergoing a BPD 29,50 .…”

Section: Resultsmentioning

confidence: 91%

“…Follow‐up ranged from 6 months to 7 years. Weight loss was expressed as change in BMI in 11 studies, 25–34 percentage excess BMI loss (EBMIL) in one study, 35 percentage TWL in nine studies, 36–44 and excess weight loss (EWL) in 29 studies 45–73 . Patients underwent various types of bariatric procedures including RYGB, SG, and LAGB.…”

Section: Resultsmentioning

confidence: 99%

Genetic variants associated with weight loss and metabolic outcomes after bariatric surgery: A systematic review

van der Meer,

Mohamed,

Monpellier

et al. 2023

Obesity Reviews

View full text Add to dashboard Cite

SummaryThe extent to which genetic variations contribute to interindividual differences in weight loss and metabolic outcomes after bariatric surgery is unknown. Identifying genetic variants that impact surgery outcomes may contribute to clinical decision making. This review evaluates current evidence addressing the association of genetic variants with weight loss and changes in metabolic parameters after bariatric surgery. A search was conducted using Medline, Embase, Scopus, Web of Science, and Cochrane Library. Fifty‐two eligible studies were identified. Single nucleotide polymorphisms (SNPs) at ADIPOQ (rs226729, rs1501299, rs3774261, and rs17300539) showed a positive association with postoperative change in measures of glucose homeostasis and lipid profiles (n = 4), but not with weight loss after surgery (n = 6). SNPs at FTO (rs11075986, rs16952482, rs8050136, rs9939609, rs9930506, and rs16945088) (n = 10) and MC4R (rs11152213, rs476828, rs2229616, rs9947255, rs17773430, rs5282087, and rs17782313) (n = 9) were inconsistently associated with weight loss and metabolic improvement. Four studies examining the UCP2 SNP rs660339 reported associations with postsurgical weight loss. In summary, there is limited evidence supporting a role for specific genetic variants in surgical outcomes after bariatric surgery. Most studies have adopted a candidate gene approach, limiting the scope for discovery, suggesting that the absence of compelling evidence is not evidence of absence.

show abstract

FABP2, LEPR223, LEP656, and FTO Polymorphisms: Effect on Weight Loss 2 Years After Bariatric Surgery

Abstract: There is a different evolution of weight loss in carriers of the LEP223 after bariatric surgery. The AA genotype seems to be associated with a higher weight loss. However, this pattern was evident only at 12 months after surgery.

Cited by 17 publications

References 24 publications

Lack of association between 11 gene polymorphisms on weight loss 1 year after Roux‐en‐y gastric bypass surgery in woman

Lack of association between 11 gene polymorphisms on weight loss 1 year after Roux‐en‐y gastric bypass surgery in woman

A Systematic Review of Genetic Correlates of Weight Loss After Bariatric Surgery

Genetic variants associated with weight loss and metabolic outcomes after bariatric surgery: A systematic review

Contact Info

Product

Resources

About