F2-isoprostanes and F4-neuroprostanes as markers of intracranial aneurysm development

Syta-Krzyżanowska, Anna; Jarocka-Karpowicz, Iwona; Kochanowicz, Jan; Rutkowski, Robert; Gorbacz, Krzysztof; Mariak, Zenon; Skrzydlewska, Elżbieta

doi:10.17219/acem/68634

Cited by 10 publications

(8 citation statements)

References 32 publications

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“…The same lipid oxidation susceptibility could affect the male reproductive traits and, in particular, the semen quality of animals feeding on n-3 PUFAs, considering that dietary source influences the PUFA profile of sperm (see Section 2.3). In agreement, recent studies (reviewed by [126]) demonstrated that lipid membrane peroxidation generates a series of molecules, namely isoprostanes, which are retained “markers of oxidation” in many male infertility-related pathologies [127] or neurodegenerative disease (i.e., Rett syndrome or Alzheimer’s disease [128]). Isoprostanes are prostaglandin-like products, which are formed via nonenzymatic, free radical-mediated peroxidation of polyunsaturated fatty acids, for example, the oxidation of arachidonic acid (n-6 LC-PUFA) produces F2-isoprostanes (F2-IsoPs), whereas the oxidation of EPA and DHA (n-3 LC-PUFAs) produces F3-isoprostanes (F3-IsoPs) and F4-neuroprostanes (F4-NeuroPs), respectively [129].…”

Section: Different Effects Of N-3 Pufasmentioning

confidence: 53%

n-3 PUFA Sources (Precursor/Products): A Review of Current Knowledge on Rabbit

Rodríguez

Rebollar

Mattioli

et al. 2019

Animals

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Simple SummaryThe nutritional quality of fat for human consumption is usually evaluated in terms of the n-6/n-3 polyunsaturated fatty acid (PUFA) ratio (with optimal values ≤4). Moreover, with respect to animal production, the standard feed is unbalanced in terms of n-6/n-3 polyunsaturated fatty acids (PUFAs) with a lower proportion of the latter. Such discrepancy negatively affects the health status of animals, the productive and reproductive performances, and the general quality of their products. Hence, n-3 PUFA intake should be promoted. The increase in n-3 PUFA proportions in animal products would also be in accordance with the human dietary recommendations that often focus on the need of increasing the intake of long-chain n-3 PUFAs. In this regard, two main strategies could be implemented, namely to furnish precursor (α-linolenic acid) or long-chain derivatives (eicosapentaenoic and docosahexaenoic acids). In the present review, the effects of different n-3 PUFA sources on biological activity, physiological/reproductive endpoints, and health implications are compared focusing on the most recent results obtained in the rabbit.AbstractThis review compares the effects of different n-3 polyunsaturated fatty acid (PUFA) sources on biological activity, physiological/reproductive endpoints, and health implications with a special emphasis on a rabbit case study. Linoleic acid (LA) and α-linolenic acid (ALA) are members of two classes of PUFAs, namely the n-6 and n-3 series, which are required for normal human health. Both are considered precursors of a cascade of molecules (eicosanoids), which take part in many biological processes (inflammation, vasoconstriction/vasodilation, thromboregulation, etc.). However, their biological functions are opposite and are mainly related to the form (precursor or long-chain products) in which they were administered and to the enzyme–substrate preference. ALA is widely present in common vegetable oils and foods, marine algae, and natural herbs, whereas its long-chain PUFA derivatives are available mainly in fish and animal product origins. Recent studies have shown that the accumulation of n-3 PUFAs seems mostly to be tissue-dependent and acts in a tissue-selective manner. Furthermore, dietary n-3 PUFAs widely affect the lipid oxidation susceptibility of all tissues. In conclusion, sustainable sources of n-3 PUFAs are limited and exert a different effect about (1) the form in which they are administered, precursor or derivatives; (2) their antioxidant protections; and (3) the purpose to be achieved (health improvement, physiological and reproductive traits, metabolic pathways, etc.).

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Section: Different Effects Of N-3 Pufasmentioning

confidence: 53%

n-3 PUFA Sources (Precursor/Products): A Review of Current Knowledge on Rabbit

Rodríguez

Rebollar

Mattioli

et al. 2019

Animals

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“…An alternative to the formation of reactive aldehydes is the intramolecular cyclization of lipid hydroperoxides. This causes the formation of prostaglandin derivatives, including isoprostanes (mainly from arachidonic acid) and neuroprostanes (mainly from docosahexaenoic acid), which are characterized by the presence of a cyclopentane ring [79,80]. Cyclic derivatives increase the production of ROS in mitochondria and further disturb the redox balance by oxidizing endogenous antioxidants, in particular, GSH [80].…”

Section: Ros-dependent Lipid Peroxidation Productsmentioning

confidence: 99%

Involvement of Metabolic Lipid Mediators in the Regulation of Apoptosis

et al. 2020

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Apoptosis is the physiological mechanism of cell death and can be modulated by endogenous and exogenous factors, including stress and metabolic alterations. Reactive oxygen species (ROS), as well as ROS-dependent lipid peroxidation products (including isoprostanes and reactive aldehydes including 4-hydroxynonenal) are proapoptotic factors. These mediators can activate apoptosis via mitochondrial-, receptor-, or ER stress-dependent pathways. Phospholipid metabolism is also an essential regulator of apoptosis, producing the proapoptotic prostaglandins of the PGD and PGJ series, as well as the antiapoptotic prostaglandins of the PGE series, but also 12-HETE and 20-HETE. The effect of endocannabinoids and phytocannabinoids on apoptosis depends on cell type-specific differences. Cells where cannabinoid receptor type 1 (CB1) is the dominant cannabinoid receptor, as well as cells with high cyclooxygenase (COX) activity, undergo apoptosis after the administration of cannabinoids. In contrast, in cells where CB2 receptors dominate, and cells with low COX activity, cannabinoids act in a cytoprotective manner. Therefore, cell type-specific differences in the pro- and antiapoptotic effects of lipids and their (oxidative) products might reveal new options for differential bioanalysis between normal, functional, and degenerating or malignant cells, and better integrative biomedical treatments of major stress-associated diseases.

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“…Syta-Krzyzanowska et al [62] showed that in cerebral tissues, where the level of DHA is high (similarly to testes), a pathological situation (e.g., aneurysm) leads to the enhancement of lipid peroxidation with an increase in plasma F 2 -IsoPs and F 4 -NeuroPs (more than three-fold and eleven-fold, respectively). Related work [63] suggested that the metabolism of LC PUFA yields oxidised bioactive compounds that 9 Oxidative Medicine and Cellular Longevity mediate its effects.…”

mentioning

confidence: 99%

Effect of Dietaryn‐3Source on Rabbit Male Reproduction

Castellini

Mattioli

Signorini

et al. 2019

Oxidative Medicine and Cellular Longevity

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In the last two decades, the human sperm count linearly decreased in Western countries. Health problems, lifestyle, pollutants, and dietary behaviours are considered as the main risk factors, and the unbalance of dietary n‐6/n‐3 fatty acids is one of the most relevant. The aim of the present research is to study the effect of different dietary sources of n‐3 polyunsaturated fatty acids (PUFA) on reproductive traits using rabbit buck as the animal model. Fifteen rabbit bucks were assigned to three experimental groups: the control group, the FLAX group fed 10% extruded flaxseed, and the FISH group fed 3.5% fish oil for 110 days (50-day adaptation and 60-day experimental periods). Semen samples were collected weekly, whereas blood was collected every two weeks for the analytical determination of semen traits, oxidative status, fatty acid profiles, isoprostanes, neuroprostanes, and the immunocytochemistry of docosahexaenoic acid (DHA) and eicosapentaenoic (EPA) acid. At the end of the trial, the rabbits were killed and the testes were removed and stored for the analysis of fatty acid profile and immunocytochemistry. Results showed that dietary administration of n‐3 PUFA improved the track speed of the sperm and increased the n‐3 long-chain PUFA mainly confined in the sperm tail. Seminal plasma increased the thiobarbituric reactive substances (TBARs) by three times in the groups fed supplemental n‐3, whereas the F2-isoprotanes (F2-IsoPs) and F4-neuroprostanes (F4-NeuroPs) were lower and higher, respectively, in both supplemented groups than in the control. The testes and sperm showed a higher DHA and EPA distribution in rabbits from the n‐3 supplemented groups compared with the control. In conclusion, supplemental dietary n‐3 PUFA improved sperm motion traits and resulted in an enrichment of membrane fatty acid in the sperm and testes of the rabbits. However, such an increased amount of PUFA negatively affected the sperm oxidative status, which was mainly correlated with the generation of F4-NeuroPs with respect to F2-IsoPs. Accordingly, the latter cannot be considered a good marker of oxidation when diets rich in n‐3 PUFA are provided.

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F2-isoprostanes and F4-neuroprostanes as markers of intracranial aneurysm development

Abstract: Background. Intracranial aneurysms are common, occurring in about 1-2% of the population. Saccular aneurysm is a pouch-like pathological dilatation of an intracranial artery that develops when the cerebral artery wall becomes too weak to resist hemodynamic pressure and distends.

Cited by 10 publications

References 32 publications

n-3 PUFA Sources (Precursor/Products): A Review of Current Knowledge on Rabbit

n-3 PUFA Sources (Precursor/Products): A Review of Current Knowledge on Rabbit

Involvement of Metabolic Lipid Mediators in the Regulation of Apoptosis

Effect of Dietaryn‐3Source on Rabbit Male Reproduction

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