F18 FDG positron emission tomography revelation of primary testicular lymphoma with concurrent multiple extra nodal involvement

Vamsy, Mohana; Dattatreya, PS; Parakh, Megha; Dayal, Monal; Rao, Vvs Prabhakar

doi:10.4103/0972-3919.116816

Cited by 1 publication

(1 citation statement)

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“…The OS of patients with low to moderate FDG uptake was reported to be significantly longer than that of patients with high FDG uptake ( 17 ). PTL with high FDG uptake tended to exhibit poor treatment response as compared to that with low to moderate uptake ( 18 ). This prognostic information yielded by FDG PET over SUV max values was very accentuated in our study.…”

Section: Discussionmentioning

confidence: 99%

Utility of FDG PET/CT in the Management of Primary Testicular Lymphoma

Okuyucu

İnce

Alagöz

et al. 2018

Mirt

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Objective:Primary testicular lymphoma (PTL) is a form of extra-nodal lymphoma originating from the testicles. Currently, positron emission tomography (PET) with glucose analogue 18F-fluorodeoxyglucose (18F-FDG) is the most popular and widely used modality for evaluating tumor metabolism, and PTL usually displays increased 18F-FDG uptake. Despite the rapid increase in clinical applications of FDG PET/ computed tomography (CT), its role in PTL has neither been clearly defined nor reviewed systematically. This study reviews the usefulness and limitation of FDG PET/CT in the diagnosis and treatment of PTL.Methods:This study included 12 patients with PTL between 2004 and 2015. We retrospectively examined PET/CT results along with patient outcome. The maximum standardized uptake value (SUVmax) was calculated.Results:The mean overall survival (OS) and disease-free survival (DFS) was 44.5 months and 35.5 months, respectively. The mean SUVmax was identified as 18.5 in recurrent/metastatic group. The 1-year and 3-year OS was 94% and 69%, while the 1-year and 2-year DFS was 93.5% and 56%, respectively.Conclusion:FDG PET/CT is very helpful in both staging and evaluating treatment response. Although it is not a perfect tool in the initial diagnosis, it might aid in the differential diagnosis of challenging testicular tumors. Pre-treatment and post-treatment FDG uptake values may also have a prognostic value in patients with PTL.

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Section: Discussionmentioning

confidence: 99%