F<scp>rom</scp> D. S. DAVIES, M.D., LL.D., D.P.H.

Davies, D. S.

doi:10.1111/j.1360-0443.1925.tb04596.x

Cited by 14 publications

(16 citation statements)

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“…The membranes are bulged until fracture occurs and the stress distribution (4) at the moment of failure is used to analyze the brittle material strength as explained in detail elsewhere [7,8,14,15]. Figure 4 shows the data obtained from bulge measurements up to fracture for the Table II.…”

Section: Resultsmentioning

confidence: 99%

“…PA 792/1-2 is gratefully acknowledged. different films and the fits to standardized Weibull distributions, from which the mean fracture strength µ (normalized to the reference volume V E = 2.5×10 5 µm 3 ) and Weibull modulus m are extracted [8,14,15]. It is here assumed that fracture originates in flaws uniformly distributed within the…”

Section: Conclusion and Acknowledgmentmentioning

confidence: 99%

“…Mechanical thin film parameters are obtained from the fit of the model to the experimental data. In addition, the stress distribution within the diaphragms at the moment of failure is computed and used to analyze the brittle material strength via Weibull distributions [7,8]. The inclusion of compliant supports in the multilayer model enables a more accurate description of the stress distribution and, consequently, a more precise extraction of fracture strengths for arbitrary thin film stacks.…”

Section: Introductionmentioning

confidence: 99%

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Mechanical Characterization of Thin-Film Composites using the Load-Deflection Response of Multilayer Membranes - Elastic and Fracture Properties

2006

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This paper reports on the refinement of a mechanical model for the load-deflection of multilayer membranes under uniform differential pressure and on its application to the experimental extraction of material parameters. Going beyond previous results, the analytical model takes into account the mechanics of multilayers and elastic supports covering all cases between rigidly clamped to simply supported structures and enables the straightforward assessment of stress profiles within the deformed structures. A comprehensive set of long membranes made of various multilayers of silicon nitride and oxide films are fabricated and characterized. The out-of-plane deflection profile under pressure load is monitored by means of a laser profilometer. The pressure is stepped up until fracture occurs. From the stress profiles in the membrane at fracture, the brittle material strength is analyzed using Weibull statistics. The bulge setup has been fully automated for the measurement of 80 membranes per wafer. This realizes, for the first time, the high throughput-acquisition of mechanical thin film data with convincing statistical control.

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Section: Resultsmentioning

confidence: 99%

Section: Conclusion and Acknowledgmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mechanical Characterization of Thin-Film Composites using the Load-Deflection Response of Multilayer Membranes - Elastic and Fracture Properties

2006

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“…The determined E,,, is considerably lower than that of the wild type enzyme (-138 mV). However, since the Em of reduced Pd is -233 mV [24], the electron transfer from reduced Pd to the mutant P450cam should be possible. In fact, the Th?…”

Section: Defects In Electron Transfer From Pd To P-450cammentioning

confidence: 99%

Essential role of the Arg¹¹² residue of cytochrome P450cam for electron transfer from reduced putidaredoxin

Koga¹,

Sagara²,

Yaoi³

et al. 1993

FEBS Letters

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Cytochrome P450cam (CYP101) of Pseudomonas putida PpGl in which Arg112 is substituted by Cys was isolated by in vitro random mutagenesis of the camC gene DNA coding for P450cam. The absorption spectra of the purified mutant enzyme were similar to those of the wild type enzyme, but its substrate‐dependent NADH oxidation activity in the presence of putidaredoxin (Pd) and putidaredoxin reductase (PdR) was extremely low. The rate constant of electron transfer from reduced Pd to the heme of the mutant P450cam, measured on an anaerobic stopped flow apparatus, was 1/400 of that of the wild type enzyme and the dissociation constant of the mutant P450cam for oxidized Pd was several fold higher than that of the wild type enzyme. A considerable decrease in mid‐point potential of the mutant enzyme was also noted. We conclude that Arg112, which is located on the surface of the P450cam molecule and hydrogen‐bonded to one of the heme propionate chains, plays an essential role in the electron transfer from Pd.

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“…Paraquat's herbicidal activity appears to depend upon its ability to generate superoxide (O), a reactive form of oxygen (Fletcher 1974). We have shown that enzymes in rat lung (Davies & Davies 1974) are able to reduce paraquat to its radical ion which, in the presence of oxygen, generates superoxide. As in plants, this may be the toxic agent in the lung.…”

mentioning

confidence: 99%

PARAQUAT POISONING - Possible Therapeutic Approach

Davies

Conolly

1975

Lung Metabolism

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From D. S. DAVIES, M.D., LL.D., D.P.H.

Cited by 14 publications

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Mechanical Characterization of Thin-Film Composites using the Load-Deflection Response of Multilayer Membranes - Elastic and Fracture Properties

Mechanical Characterization of Thin-Film Composites using the Load-Deflection Response of Multilayer Membranes - Elastic and Fracture Properties

Essential role of the Arg¹¹² residue of cytochrome P450cam for electron transfer from reduced putidaredoxin

PARAQUAT POISONING - Possible Therapeutic Approach

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From D. S. DAVIES, M.D., LL.D., D.P.H.

Cited by 14 publications

References 0 publications

Mechanical Characterization of Thin-Film Composites using the Load-Deflection Response of Multilayer Membranes - Elastic and Fracture Properties

Mechanical Characterization of Thin-Film Composites using the Load-Deflection Response of Multilayer Membranes - Elastic and Fracture Properties

Essential role of the Arg112 residue of cytochrome P450cam for electron transfer from reduced putidaredoxin

PARAQUAT POISONING - Possible Therapeutic Approach

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Essential role of the Arg¹¹² residue of cytochrome P450cam for electron transfer from reduced putidaredoxin