F-18 FDG Uptake in the Large Arteries

Yun, Mijin; Yeh, David; Araujo, Louis I.; Jang, Sung Jun; Newberg, Andrew; Alavi, Abass

doi:10.1097/00003072-200104000-00007

Cited by 233 publications

(149 citation statements)

References 10 publications

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“…Yun et al have evaluated the presence of FDG vascular uptake in the abdominal aorta, iliac, and proximal femoral arteries in 137 consecutive patients undergoing PET scan, mainly for malignancy (29). Fifty percent of the patients showed vascular uptake in at least one vessel, with an increased prevalence in older patients.…”

Section: Discussionmentioning

confidence: 99%

Positron emission tomography (PET): Evaluation of chronic periaortitis

Salvarani¹,

Pipitone²,

Versari³

et al. 2005

Arthritis & Rheumatism

131

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Objective. To evaluate the presence and extent of large-vessel inflammation in patients with chronic periaortitis (CP) using 18 F-fluorodeoxyglucose-positron emission tomography (FDG-PET). Methods. A consecutive case series consisting of 7 patients with CP seen over a 3-year period and a control group of 14 patients with malignancy were evaluated with FDG-PET. For every case we selected 2 age-and sex-matched controls who underwent PET imaging for malignancy. The diagnosis of CP was made by means of computed tomography. PET imaging was performed at diagnosis before therapy was started. Measurement of vascular uptake was graded using a 4-point semiquantitative scale. Results. All patients had evidence of grade 2؉ or 3؉ vascular uptake in the abdominal aorta and/or iliac artery. No controls showed vascular uptake greater than 1؉. Vascular uptake in the thoracic aorta and/or in its branches was seen in 3 (43%) of 7 patients. Vascular uptake in abdominal aorta and/or iliac artery was observed in patients with CP but not in controls (100% versus 0%). There was also a significantly more frequent FDG uptake in the large thoracic arteries in case-patients compared with controls (43% versus 0%; P ‫؍‬ 0.03). Conclusion. FDG-PET scan shows in patients with CP the presence of a large-vessel vasculitis involving abdominal aorta and common iliac arteries, which in some patients is also extended to thoracic aorta and/or its branches.

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Section: Discussionmentioning

confidence: 99%

Positron emission tomography (PET): Evaluation of chronic periaortitis

Salvarani¹,

Pipitone²,

Versari³

et al. 2005

Arthritis & Rheumatism

131

View full text Add to dashboard Cite

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“…However, case studies subsequently noted vascular uptake even in the absence of vasculitis (55). Retrospective analysis of 18 F-FDG PET scans in patients undergoing oncological workup identified vessel wall uptake in as many as 50% (56). In a number of cases this uptake was nonuniform along the length of the vessel and in one case where uptake extended from the abdominal aorta to the femoral arteries, it was recognized that this corresponded to extensive atherosclerotic disease seen also on CT imaging.…”

Section: F-fdg Detection Of Vascular Inflammationmentioning

confidence: 99%

Future imaging of atherosclerosis: molecular imaging of coronary atherosclerosis with 18F positron emission tomography

Scherer

Psaltis

2016

Cardiovasc. Diagn. Ther.

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Atherosclerosis is characterized by the formation of complex atheroma lesions (plaques) in arteries that pose risk by their flow-limiting nature and propensity for rupture and thrombotic occlusion.It develops in the context of disturbances to lipid metabolism and immune response, with inflammation underpinning all stages of plaque formation, progression and rupture. As the primary disease process responsible for myocardial infarction, stroke and peripheral vascular disease, atherosclerosis is a leading cause of morbidity and mortality on a global scale. A precise understanding of its pathogenic mechanisms is therefore critically important. Integral to this is the role of vascular wall imaging. Over recent years, the rapidly evolving field of molecular imaging has begun to revolutionize our ability to image beyond just the anatomical substrate of vascular disease, and more dynamically assess its pathobiology. Nuclear imaging by positron emission tomography (PET) can target specific molecular and biological pathways involved in atherosclerosis, with the application of 18 Fluoride PET imaging being widely studied for its potential to identify plaques that are vulnerable or high risk. In this review, we discuss the emergence of 18 Fluoride PET as a promising modality for the assessment of coronary atherosclerosis, focusing on the strengths and limitations of the two main radionuclide tracers that have been investigated to date: 2-deoxy-2-(

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“…After anecdotal reports, aortic FDG uptake in patients undergoing FDG-PET imaging for oncology staging was described in 2001 [41], and later noted as increasing with age [42], male sex and the presence of vascular risk factors [43][44][45]. In the first prospective clinical study, Rudd et al [46] imaged eight patients shortly after transient ischaemic attack (TIA) with FDG-PET and reported an FDG accumulation rate 27% higher in the symptomatic carotid compared to the contralateral asymptomatic side.…”

Section: Clinical Studies With Fdg-petmentioning

confidence: 99%

Vascular imaging with positron emission tomography

Joshi

Rosenbaum

Bordes

et al. 2011

Journal of Internal Medicine

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Atherosclerosis is an inflammatory disease that causes most myocardial infarctions, strokes and acute coronary syndromes. Despite the identification of multiple risk factors and widespread use of drug therapies, it still remains a global health concern with associated costs. Although angiography is established as the gold standard means of detecting coronary artery stenosis, it does not image the vessel wall itself, reporting only on its consequences such as luminal narrowing and obstruction. MRI and computed tomography provide more information about the plaque structure, but recently positron emission tomography (PET) imaging using [ 18 F]-fluorodeoxyglucose (FDG) has been advocated as a means of measuring arterial inflammation. This results from the ability of FDG-PET to highlight areas of high glucose metabolism, a feature of macrophages within atherosclerosis, particularly in high-risk plaques. It is suggested that the degree of FDG accumulation in the vessel wall reflects underlying inflammation levels and that tracking any changes in FDG uptake over time or with drug therapy might be a way of getting an early efficacy readout for novel anti-atherosclerotic drugs. Early reports also demonstrate that FDG uptake is correlated with the number of cardiovascular risk factors and possibly even the risk of future cardiovascular events. This review will outline the evidence base, shortcomings and emerging applications for FDG-PET in vascular imaging. Alternative PET tracers and other candidate imaging modalities for measuring vascular inflammation will also be discussed.

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F-18 FDG Uptake in the Large Arteries

Cited by 233 publications

References 10 publications

Positron emission tomography (PET): Evaluation of chronic periaortitis

Positron emission tomography (PET): Evaluation of chronic periaortitis

Future imaging of atherosclerosis: molecular imaging of coronary atherosclerosis with 18F positron emission tomography

Vascular imaging with positron emission tomography

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